The impact of abnormal autoimmune function on reproduction: Maternal and fetal consequences

Gleicher, Norbert; Weiner, Rebecca L.; Vietzke, Mary

doi:10.1016/j.jaut.2006.08.003

Cited by 25 publications

(19 citation statements)

References 21 publications

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“…There are autoimmune diseases that can have an adverse effect on pregnancy and perinatal outcome, including recurrent spontaneous miscarriages, premature deliveries, and perinatal mortality [7][8][9]. Systemic lupus erythematosus (SLE) is association with perinatal morbidity and mortality [10].…”

Section: Introductionmentioning

confidence: 99%

The influence of visual impairment on pregnancy outcomes

Ofir

Kessous

Belfer

et al. 2014

Arch Gynecol Obstet

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Section: Introductionmentioning

confidence: 99%

The influence of visual impairment on pregnancy outcomes

Ofir

Kessous

Belfer

et al. 2014

Arch Gynecol Obstet

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“…That reporting biases can also interact with each other is demonstrated by the decrease in miscarriage rates over recent years in women with SLE [28] and with autoimmune diseases in general [32], both very likely results of increasingly successful preconception counseling and therapeutic interventions. All of this, therefore, suggests that associations between autoimmune function and premature labor have to be considered strongly biased against such a finding.…”

Section: Difficulties In Evaluating Associations Between Ptd and (Autmentioning

confidence: 99%

Does the Immune System Induce Labor? Lessons from Preterm Deliveries in Women with Autoimmune Diseases

Gleicher

2009

Clinic Rev Allerg Immunol

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A recent review of the literature suggested that thyroid autoimmunity is statistically associated with preterm delivery. This observation raises a number of follow-up questions, among them whether autoimmune function, in general, predisposes to premature delivery. A review of the English literature for the last 10 years, via PubMed search, finds strong supportive evidence for such a hypothesis. Since the fetal-placental unit represents a (semi) allograft within a maternal (allograft) recipient, it is reasonable to assume that it is subject to similar immunologic tolerance (and failure thereof) as solid organ transplants. As autoimmune responses represent a normal feature of tolerance failure in organ transplantation, similar autoimmune responses can also be expected with failure of tolerance of the fetal-maternal graft. The association of premature (and possibly also term) labor with autoimmune function may, therefore, be the consequence of abnormalities in normal fetal-placental tolerance, leading to uterine activation and labor.

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“…In recurrent pregnancy losses, aPL, antiprothrombin, and antisaccharomycetes cerevisiae antibodies were more prevalent than in controls, with odd ratio of 4.8, 5.4, and 3.9 for each antibody, respectively. Therefore, although there is a general consensus to screen for aPL in patients with recurrent pregnancy losses, larger cohort studies are necessary to determine the true incidence of recurrent pregnancy losses in the presence of other autoantibody or combinations of autoantibodies [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66]. In addition, these cohort studies should either be corrected for the subsequent miscarriages caused by fetal chromosomal aberrations, or use multivariate analysis to corect for the effect of confounding factors such as maternal age.…”

Section: Other Autoantibodies and Recurrent Pregnancy Lossesmentioning

confidence: 99%

Autoimmunity and Recurrent Pregnancy Losses

Cervera

Balasch

2009

Clinic Rev Allerg Immunol

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The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antiphospholipid antibodies seem to be clearly associated with recurrent miscarriage. Although there is no agreement on the mechanisms of recurrent pregnancy losses in patients with these antibodies, vasculopathy of the terminal spiral arteries may be implicated and there is a general consensus to routinely screen for antiphospholipid antibodies in patients with recurrent miscarriage. Well-designed diagnostic studies are needed to estimate the true association between other specific autoantibodies and recurrent miscarriage.

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The impact of abnormal autoimmune function on reproduction: Maternal and fetal consequences

Cited by 25 publications

References 21 publications

The influence of visual impairment on pregnancy outcomes

The influence of visual impairment on pregnancy outcomes

Does the Immune System Induce Labor? Lessons from Preterm Deliveries in Women with Autoimmune Diseases

Autoimmunity and Recurrent Pregnancy Losses

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