The impact of aerobic exercise training on cognitive function and gut microbiota in methamphetamine-dependent individuals in the community

Zhu, Yuemin; Zhu, Jiang; Song, Guang‐Ling

doi:10.1016/j.physbeh.2023.114302

Cited by 6 publications

(3 citation statements)

References 87 publications

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“…At the genus level, Ruminococcus gauvreauii, Anaerostipes, and an uncultured genus from Lachnospiraceae, all belonging to the SCFA-producing Firmicutes phylum, were found to have a significantly increasing relative abundance in the adult gut after exercise intervention, which was positively correlated with insulin sensitivity and cardiorespiratory fitness [22,29]. A sharp increase in the abundance of Bifidobacterium was reported in many studies of this review [15,17,26,29,34,38], portending a positive association with producing acetate [50,51]. The metabolic pathway of acetate in the gut epithelial cells could increase the release of IL-18 and then engage the epithelial IL-18 receptor and promote intestinal barrier integrity [52].…”

Section: Scfas-producing Bacteriamentioning

confidence: 51%

“…Moreover, Bifidobacterium could achieve emotional regulation through the brain-gut axis, showing a negative correlation with severe depression in mice [26,55]. Four studies in this review observed a significant difference between groups in Akkermansia [14,29,38,39], which has been previously described to have a high prevalence in the gut microbiome of athletes. It is noteworthy that the abundance of Akkermansia has been reported to inversely correlate with obesity and metabolic disorders in mice and humans (reference).…”

Section: Other Representative Bacteriamentioning

confidence: 61%

“…In this review, the abundance of some representative beneficial bacteria showed a significant difference in athletes compared to sedentary people or other inactive groups, indicating an enhancement of the GM composition and human health. Of these bacteria, the genera of Bifidobacterium, Akkermansia, Lactococcus, and Coprococcus were found to have a much higher relative abundance in physically active adults [15,17,20,23,24,26,29,38]. In recent years, Bifidobacterium has been widely used as probiotics and declared to have a beneficial impact on many pathological conditions, simultaneously being regarded as mediator of lactate metabolism for producing butyrate [15,53].…”

Section: Other Representative Bacteriamentioning

confidence: 99%

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Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis

Min,

Ablitip,

Wang

et al. 2024

Nutrients

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Background: The equilibrium between gut microbiota (GM) and the host plays a pivotal role in maintaining overall health, influencing various physiological and metabolic functions. Emerging research suggests that exercise modulates the abundance and functionality of gut bacteria, yet the comprehensive effects on GM diversity remain to be synthesized. Objectives and Design: The study aims to quantitatively examine the effect of exercise on the diversity of gut microbiota of adults using a systemic review and meta-analysis approach. Methods: PubMed, Ebsco, Embase, Web of Science, Cochrane Central Register of Controlled Trials, the China National Knowledge Infrastructure, and Wanfang Data were searched from their inception to September 2023. Exercise intervention studies with a control group that describe and compare the composition of GM in adults, using 16S rRNA gene sequencing, were included in this meta-analysis. Results: A total of 25 studies were included in this meta-analysis with a total of 1044 participants. Based on a fixed-effects model [Chi2 = 29.40, df = 20 (p = 0.08); I2 = 32%], the pooled analysis showed that compared with the control group, exercise intervention can significantly increase the alpha diversity of adult GM, using the Shannon index as an example [WMD = 0.05, 95% CI (0.00, 0.09); Z = 1.99 (p = 0.05)]. In addition, exercise interventions were found to significantly alter GM, notably decreasing Bacteroidetes and increasing Firmicutes, indicating a shift in the Firmicutes/Bacteroidetes ratio. The subgroup analysis indicates that females and older adults appear to exhibit more significant changes in the Shannon Index and observed OTUs. Conclusions: Exercise may be a promising way to improve GM in adults. In particular, the Shannon index was significantly increased after exercise. Distinct responses in GM diversity to exercise interventions based on gender and age implicated that more research was needed.

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Section: Scfas-producing Bacteriamentioning

confidence: 51%

Section: Other Representative Bacteriamentioning

confidence: 61%

Section: Other Representative Bacteriamentioning

confidence: 99%

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Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis

Min,

Ablitip,

Wang

et al. 2024

Nutrients

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The role of physical exercise on the brain and cognitive functions of patients in recovery from substance use disorder: A narrative review and recommendations for researchers and practitioners

Cabral,

Dongshi,

Schuch

et al. 2024

Mental Health and Physical Activity

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Running ameliorates methamphetamine-associated cognitive impairment by regulating hippocampal neurogenesis through the GSK3β/β-catenin pathway

Wang,

Lu,

Chen

et al. 2024

Preprint

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Physical exercise is a non-pharmacological therapy that has been widely used in drug rehabilitation centers for the treatment of methamphetamine (METH). METH caused cognitive impairment and suppresses adult hippocampal neurogenesis (AHN) in experimental animals. Exercise can improve cognitive impairment caused by multiple factors through AHN. However, little is known about the role of AHN and exercise in METH-neurotoxic injury. We aim to investigate whether running could ameliorate METH-related cognitive impairment by promoting AHN and the underlying mechanisms. Behavioral experiments were performed to detect behavioral changes in running exercise-treated mice exposed to METH. Immunofluorescence was used to analyze the hippocampal neurogenic lineage, and western blotting and qRT-PCR were used to analyze the expression levels of GSK3β/β-catenin and downstream transcription factors. AAV-Nestin-Ctnnb1 was used to overexpress β-catenin in neural stem cells (NSCs). We found that low-dose METH induced cognitive impairment and decreased AHN instead of inducing cell death in the hippocampus. Moreover, it diminished the proliferation and differentiation of NSCs in the dentate gyrus. Running ameliorated METH-related cognitive impairment by modulating AHN through the GSK3β/β-catenin pathway. Notably, overexpressing β-catenin in NSCs promoted the expression of its downstream transcription factors, rescued AHN, and exerted effects of ameliorating cognitive impairment. Our findings show that METH could cause cognitive impairment through weaken the AHN, and running could effectively ameliorate METH-related cognitive impairment by enhancing AHN through the GSK3β/β-catenin pathway. In addition, our findings provide insights into how exercise ameliorates METH-related cognitive impairment and theoretical basis for exercise therapy.

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The impact of aerobic exercise training on cognitive function and gut microbiota in methamphetamine-dependent individuals in the community

Cited by 6 publications

References 87 publications

Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis

Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis

The role of physical exercise on the brain and cognitive functions of patients in recovery from substance use disorder: A narrative review and recommendations for researchers and practitioners

Running ameliorates methamphetamine-associated cognitive impairment by regulating hippocampal neurogenesis through the GSK3β/β-catenin pathway

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