The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial

Kimhy, David; Vakhrusheva, Julia; Bartels, Matthew N.; Armstrong, Hilary F.; Ballon, Jacob S.; Khan, Samira; Chang, Rachel W.; Hansen, Marie C.; Ayanruoh, Lindsey; Lister, Amanda; Ċastrén, Eero; Smith, Edward E.; Sloan, Richard P.

doi:10.1093/schbul/sbv022

Cited by 176 publications

(187 citation statements)

References 69 publications

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“…Also, the increased risk of physical illnesses in patients with mental disorders [6] underlines the great importance of improvements of physical performance in schizophrenia. The finding of increased endurance capacity in patients with schizophrenia after endurance training is in agreement with other studies [21,24,[37][38][39][40][41][42][43][44] though in some studies, the methods are poorly described and the quality of the results cannot be judged properly. Still, to our knowledge no study to date has demonstrated these improvements with the set of outcome parameters used in this study.…”

Section: Discussionsupporting

confidence: 90%

“…Future research should target these therapeutic effects of endurance training more specifically with the goal to subsequently use training purposefully in therapeutic regimens. Some therapeutic effects of exercise have already been shown in schizophrenia, for example improved neurocognition [10,42,59]. Single studies and meta-analyses reported positive effects of physical activity on schizophrenia symptoms and everyday functioning [13,14,38,60,61].…”

Section: Future Researchmentioning

confidence: 98%

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Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Keller-Varady

Hasan

Schneider‐Axmann

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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The aims were to examine the feasibility of and adaptations to endurance training in persons diagnosed with schizophrenia and to address the question whether the principles and beneficial effects of endurance training established in the healthy population apply also to patients with schizophrenia. In this controlled interventional study, 22 patients with schizophrenia and 22 healthy controls performed a standardized aerobic endurance training on bicycle ergometers over 12 weeks. Another group of 21 patients with schizophrenia played table soccer. Endurance capacity was measured with incremental cycle ergometry before and after the intervention and 3 months later. A specific set of outcome parameters was defined. The training stimuli can be assumed to be similar in both endurance groups. Endurance capacity improved significantly in the endurance groups, but not in the table soccer group. Patients and healthy controls showed comparable adaptations to endurance training, as assessed by physical working capacity and maximal achieved power. Differences were found in changes of performance at a lactate concentration of 3 mmol/l. Endurance training was feasible and effective in both groups. The principles and types of training that are usually applied to healthy controls need to be verified in patients with schizophrenia. Nevertheless, patients benefited from endurance training in terms of improvement of endurance capacity and reduction in the baseline deficit in comparison with healthy controls. Therefore, endurance training should be implemented in future therapy programs. These programs need to pay special attention to the differences between patients with schizophrenia and healthy controls.

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Section: Discussionsupporting

confidence: 90%

Section: Future Researchmentioning

confidence: 98%

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Keller-Varady

Hasan

Schneider‐Axmann

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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show abstract

“…Previous research [37,38] suggested that aerobic fitness improvements following exercise might be a testable mechanism. Kimhy et al [39] showed recently that the increased production of brain-derived neurotrophic growth factors (BDNF) following aerobic fitness improvements probably plays a particular role. More interventional and longitudinal exploration of the underlying mechanisms for brain health improvements in patients with schizophrenia following a physical exercise program is needed.…”

Section: What Are the Mechanisms Of The Physical Activity Effects In mentioning

confidence: 99%

What are the top 10 physical activity research questions in schizophrenia?

Vancampfort

Rosenbaum

Probst

et al. 2016

Disability and Rehabilitation

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Purpose: Research has only recently started to consider the applicability of physical activity (PA) for people with schizophrenia. Although there is increasing evidence for the benefits of physical activity, this population remains generally physically inactive and sedentary. The aim of the current study is to highlight 10 pertinent physical activity research questions in people with schizophrenia.

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“…Trainers can foster their rhythms through the interaction with the computer. With our approaches, the digitalization and informatization of basic aerobics training and other training levels can be further developed [3][4][5]. Literature review Human-computer interaction is defined as a technology that realizes the dialogue between human and computer in effective ways and that studies computer, human kinds, and their mutual influence.…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Application of Kinect Technology in Blind Aerobics Learning

2017

Int. J. Emerg. Technol. Learn.

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Abstract-In order for blind people to learn aerobics more conveniently, we combined Kinect skeletal tracking technology with aerobics-assisted training to design a Kinect-based aerobics-assisted training system. Through the Kinect somatosensory camera, the feature extraction method and recognition algorithm of sign language are improved, and the sign language recognition system is realized. Sign language is translated through the sign language recognition system and expressed in understandable terms, providing a sound way of learning. The experimental results show that the system can automatically collect and recognize the aerobics movements. By comparing with the standard movements in the database, the system evaluates the posture of trainers from the perspectives of joint coordinates and joint angles, followed by the provision of movements contrast graphics and corresponding advice. Therefore, the system can effectively help the blind to learn aerobics. Keywords IntroductionIn the current process of aerobics training, learners reach the goal of exercise usually by repeatedly watching the video or by consulting coaches [1]. This is not only time-and effort-consuming, but brings great challenges to the blind. The meaning of our research is to combine aerobics training with Kinect skeletal tracking technology, such that the postures and movements can be captured and matched up with standard movements. Subsequently, the differences in the skeletal direction are analyzed and showed to blind people in a straightforward way, enabling them to find the gaps [2]. This method allows blind aerobics coaches and learners with high demand for teaching/self-teaching to make accurate adjustments of movements and postures that used to be below standard, so as to meet the standard of correctness. Moreover, the training process can begin at any time and in any place, which broadens teaching means. Trainers can foster their rhythms through the interaction with the computer. With our approaches, the digitalization and informatization of basic aerobics training and other training levels can be further developed [3][4][5].

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The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial

Cited by 176 publications

References 69 publications

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

Endurance training in patients with schizophrenia and healthy controls: differences and similarities

What are the top 10 physical activity research questions in schizophrenia?

Application of Kinect Technology in Blind Aerobics Learning

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