The impact of age on cardiac electromechanical function in asymptomatic individuals

Vancheri, Federico; Henein, Michael Y.

doi:10.1111/echo.14145

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Notably, there was no significant correlation between absolute LVFT and QRS duration or between absolute LVFT and LVEF. Vancheri et al did not find a significant correlation between the QRS duration and LVFT 26 . However, Charisopoulou and colleagues found that LVFT was positively correlated with stroke volume 27 .…”

Section: Discussionmentioning

confidence: 87%

Determining whether LV filling time contributes to HF symptoms in different widths of QRS in LBBB patients: a clinical study

Ahmadzadeh,

Rahimi,

Toufan-Tabrizi

et al. 2023

gcsp

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Objectives: Accurate assessment of left ventricular (LV) function is essential for managing patients with left bundle branch block (LBBB). This study aimed to evaluate the relationship between LV systolic function, left ventricular diastolic filling time (LVFT), QRS duration, and heart failure symptoms in patients with LBBB. Methods: This study was conducted between June 2021 and June 2022. Patients with LBBB and sinus rhythm who were referred to the echocardiography department were included in the study. All the patients underwent electrocardiogram-gated echocardiography using the same machine. In this study, the LVFT value was measured in absolute terms and as a ratio to the R-R interval (LVFT/RR). Results: A total of sixty-five patients were included, forty-two (64.6%) were women, and the mean age was 60.71 ± 8.72. We performed three one-way ANOVA tests that showed that LV filling time/RR ratio, QRS duration, and ejection fraction were significantly different between heart failure classes (p=0.008, p=0.001, and p<0.001, respectively). A weak correlation was observed between LVEF and LVFT/RR (r= 0.349, p=0.004). Additionally, QRS duration was negatively correlated with LVEF (r = -0.395, p=0.004) and LVFT/RR (r = -0.350, p=0.004), although these correlations were weak. Conclusion: We showed that LVFT/RR ratio differed significantly between HF functional classes and was lower in patients with more severe HF symptoms. Additionally, QRS duration was negatively correlated with LVEF and LVFT/RR, and patients with more severe HF symptoms had longer QRS durations.

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Section: Discussionmentioning

confidence: 87%

Determining whether LV filling time contributes to HF symptoms in different widths of QRS in LBBB patients: a clinical study

Ahmadzadeh,

Rahimi,

Toufan-Tabrizi

et al. 2023

gcsp

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“…The LV mechanical behavior during pre-ejection and post-ejection is a complex and controversial topic [ 8 – 10 ]. Pre-ejection is traditionally biphasic [ 11 ], the first phase is referred to as electromechanical delay (EMD) and is represented by the interval from the onset of the electrocardiographic QRS complex to mitral valve closure (MVC), and the second phase is referred to as isovolumic contraction (IC) which follows MVC and is characterized by a rapid increase in LV pressure before opening of the aortic valve.…”

Section: Discussionmentioning

confidence: 99%

Tissue Doppler derived biphasic velocities during the pre and post-ejection phases: patterns, concordance and hemodynamic significance in health and disease

Omar

Botero²,

Caraballo³

et al. 2022

Cardiovasc Ultrasound

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Background Pre-(PRE) and post-ejection (POE) velocities by mitral annular tissue Doppler (TD) are biphasic and may be related to myocardial deformations. We investigated the predominance and concordance of TD-PRE and POE velocities and their effect on myocardial functions in controls and in heart failure (HF) patients. Methods Retrospectively, 84 HF patients [57.6 years, 28(33%) females, NYHA: 2.3 ± 0.6, EF: 55 ± 15%, 52(62%) preserved EF, and 32(38%) reduced EF], 42 normal young controls, and 26 asymptomatic age matched controls were included. Echocardiography was done and from mitral annular tissue Doppler recordings, the biphasic PRE and POE velocity signals were identified and compared between groups. Results While controls had almost always predominantly positive PRE and negative POE, HF had more negative PRE and positive POE. Moreover, almost all controls exhibited normal concordance (positive PRE and negative POE). HF exhibited more abnormal concordance which was significantly associated with worse NYHA, and parameters of diastolic and systolic functions. Opposite PRE and POE velocities correlated significantly in all groups (PREp vs POEn: young:r = 0.52, p < 0.001, age controls:r = 0.79, p < 0.001, HFpEF: r = 0.56, p < 0.001, HFrEF: r = 0.42, p = 0.018; PREn vs POEp: young: r = 0.25,p = 0.1, age controls: r = 0.42, p = 0.04, HFpEF: r = 0.43, p = 0.004, HFrEF: r = 0.61, p < 0.001) and the ratios PRE-P/N and POE-N/P correlated significantly with E/e’ in HF only. Conclusions In physiological state, TD signals are predominantly positive during PRE and negative during POE. Opposite PRE and POE velocities corelate, representing the PRE-generation and POE-reversal of shortening–stretch relationships, the attenuation of which in HF may be related to elevated LV filling pressures. In HF, partially or completely reversed concordance of PRE and POE is associated with progressive worsening of clinical and hemodynamic profiles.

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The impact of age on cardiac electromechanical function in asymptomatic individuals

Cited by 2 publications

References 38 publications

Determining whether LV filling time contributes to HF symptoms in different widths of QRS in LBBB patients: a clinical study

Determining whether LV filling time contributes to HF symptoms in different widths of QRS in LBBB patients: a clinical study

Tissue Doppler derived biphasic velocities during the pre and post-ejection phases: patterns, concordance and hemodynamic significance in health and disease

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