The impact of age on oral squamous cell carcinoma: A longitudinal cohort study of 2,782 patients

Abstract

Background:The purposes of this study were to assess the influence of age on oral squamous cell carcinoma patients and sought to analyze the reasons that may contribute to this difference.Methods: This study enrolled 2,782 patients included 2,443 patients in a retrospective cohort to find the influence of age and 339 patients in a prospective cohort to testify these findings. The patients were divided into young age-group (≤40 years old), moderate age-group (41-75 years old), and advanced age-group (>75 years old). All patients were diagnosed as oral squamous cell carcinoma and were surgically treated in our hospital. Chi-square test, Kaplan-Meier analysis, and Cox proportional-hazards regression model were performed for statistical analysis.Results: Younger patients started smoking (p < 0.001) and drinking (p < 0.001) earlier than the older patients and consumed more tobacco (p = 0.005) and alcohol (p = 0.156). Patients with advanced age had worse outcomes in both recurrence (p = 0.002) and survival (p < 0.001). They also had more severe comorbidity (p < 0.001) and were more likely to receive conservative treatment (p = 0.011). Conclusions:Compared with young patients, older patients had worse prognosis, and it was related with their more severe comorbidity and received more conservative treatment. Young adults smoking and drinking earlier and heavier than old patients, it may relate with their occurrence of oral squamous cell carcinoma. K E Y W O R D Sage, comorbidity, oral squamous cell carcinoma, prognosis, treatment | 731 XU et al.

The interaction of interleukin-8 and PTEN inactivation promotes the malignant progression of head and neck squamous cell carcinoma via the STAT3 pathway

“…Head and neck squamous cell carcinoma (HNSCC), a common type of cancer, can cause both psychological and physiological damage to patients 1 . Tumor metastasis is the main reason for poor outcome 2 .…”

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

“…Head and neck squamous cell carcinoma (HNSCC), representing a group of tumors in the larynx, pharynx and oral cavity, is the sixth most common cancer in the world, with ~500,000 new cases worldwide each year ( 1 , 2 ). Among these cases, oral squamous cell carcinoma (OSCC) and laryngeal squamous cell carcinoma (LSCC) have a high incidence, especially in China ( 3 , 4 ), exhibiting high morbidity and mortality rates ( 5 ). According to GLOBOCAN 2012, the incidence and mortality rate of laryngeal cancer in China was 1.1/100,000 and 0.7/100,000, compared with the global incidence and mortality rate of which was 2.1/100,000 and 1.1/100,000, respectively ( 6 ).…”

Cell cycle markers and apoptotic proteins in oral tongue squamous cell carcinoma in young and elderly patients

“…In recent years, there has been an increase in the overall incidence of oral tongue squamous cell carcinoma (OTSCC) in young patients 1,2,3 at a frequency that ranges from 0.13 to 12.76% among all cases of OTSCC. 2,3,4,5,6 Males are more frequently affected by OTSCC, regardless of age, although recent studies have indicated an increase in incidence among young women. 1,3 The etiopathogenesis of OTSCC in young patients is still widely discussed in the scientific literature because many patients are not exposed to the main risk factors, such as smoking and/or alcohol consumption.…”

“…2,3,4,5,6 Males are more frequently affected by OTSCC, regardless of age, although recent studies have indicated an increase in incidence among young women. 1,3 The etiopathogenesis of OTSCC in young patients is still widely discussed in the scientific literature because many patients are not exposed to the main risk factors, such as smoking and/or alcohol consumption. 1,3,4 Heredity 4 and human papillomavirus (HPV) infection have been suggested to play a role in this age group.…”

“…1,3 The etiopathogenesis of OTSCC in young patients is still widely discussed in the scientific literature because many patients are not exposed to the main risk factors, such as smoking and/or alcohol consumption. 1,3,4 Heredity 4 and human papillomavirus (HPV) infection have been suggested to play a role in this age group. 7 Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”