The impact of age on intensive care

Akinosoglou, Karolina; Schinas, Georgios; Almyroudi, Maria Panagiota; Gogos, Charalambos; Dimοpoulos, George

doi:10.1016/j.arr.2022.101832

Cited by 21 publications

(12 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The three patient groups were divided into two subgroups based on their age: patients ≥ 65 years old and <65 years old [ 14 ]. In COVID-19, older patients (≥65, N = 89) tended to have higher ESM-1 levels compared to younger patients (N = 65), albeit not statistically significant [1825 (1056–2676) pg/mL vs. 1328 (906–2207) pg/mL, respectively, p = 0.051; Figure 1 A].…”

Section: Resultsmentioning

confidence: 99%

Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions

Keskinidou,

Vassiliou,

Jahaj

et al. 2023

IJMS

View full text Add to dashboard Cite

Aging negatively affects the endothelium. Endocan (ESM-1), an endothelium-derived soluble proteoglycan, participates in fundamental biological processes of endothelial cells. We aimed to examine the role of endothelial dysfunction and age in poor outcomes in critical illness. ESM-1 levels were measured in the sera of mechanically ventilated critically ill patients, including COVID-19, non-septic, and septic patients. The 3 patient cohorts were divided based on age (≥65 and <65). Critically ill COVID-19 patients had statistically higher ESM-1 levels compared to critically ill septic and non-septic patients. Only in critically ill septic patients were ESM-1 levels higher in older compared to younger patients. Finally, the age-subgrouped patients were further subdivided based on intensive care unit (ICU) outcome. ESM-1 levels were similar in COVID-19 survivors and non-survivors, irrespective of age. Interestingly, only for the younger critically ill septic patients, non-survivors had higher ESM-1 levels compared to survivors. In the non-septic survivors and non-survivors, ESM-1 levels remained unaltered in the younger patients and tended to be higher in the elderly. Even though endocan has been recognized as an important prognostic biomarker in critically ill patients with sepsis, in our patient cohort, increased age, as well as the extent of endothelial dysfunction, seemed to affect its prognostic ability.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions

Keskinidou,

Vassiliou,

Jahaj

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…The mean age of COVID-19 patients differs in different geographic regions [ 26 ]. Nonetheless, data from several countries have shown that elderly patients (≥60 years old) have a higher risk of severe outcomes, including hospitalization, ICU admission, and death rates, compared to young and middle-aged patients [ 27 , 28 ]. Furthermore, a study from the United States revealed an increase in the percentage of hospitalizations, ICU admissions, and fatalities among older persons (65 and older), with a majority of COVID-19 deaths occurring among them.…”

Section: Discussionmentioning

confidence: 99%

Genomic Surveillance and Mutation Analysis of SARS-CoV-2 Variants among Patients in Saudi Arabia

Alsuwairi,

Alsaleh,

Obeid

et al. 2024

Microorganisms

View full text Add to dashboard Cite

The genome of severe acute respiratory coronavirus-2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), has undergone a rapid evolution, resulting in the emergence of multiple SARS-CoV-2 variants with amino acid changes. This study aimed to sequence the whole genome of SARS-CoV-2 and detect the variants present in specimens from Saudi Arabia. Furthermore, we sought to analyze and characterize the amino acid changes in the various proteins of the identified SARS-CoV-2 variants. A total of 1161 samples from patients diagnosed with COVID-19 in Saudi Arabia, between 1 April 2021 and 31 July 2023, were analyzed. Whole genome sequencing was employed for variant identification and mutation analysis. The statistical analysis was performed using the Statistical Analytical Software SAS, version 9.4, and GraphPad, version 9.0. This study identified twenty-three variants and subvariants of SARS-CoV-2 within the population, with the Omicron BA.1 (21K) variant (37.0%) and the Delta (21J) variant (12%) being the most frequently detected. Notably, the Omicron subvariants exhibited a higher mean mutation rate. Amino acid mutations were observed in twelve proteins. Among these, the spike (S), ORF1a, nucleocapsid (N), and ORF1b proteins showed a higher frequency of amino acid mutations compared to other the viral proteins. The S protein exhibited the highest incidence of amino acid mutations (47.6%). Conversely, the ORF3a, ORF8, ORF7a, ORF6, and ORF7b proteins appeared more conserved, demonstrating the lowest percentage and frequency of amino acid mutations. The investigation of structural protein regions revealed the N-terminal S1 subunit of the S protein to frequently harbor mutations, while the N-terminal domain of the envelope (E) protein displayed the lowest mutation frequency. This study provides insights into the variants and genetic diversity of SARS-CoV-2, underscoring the need for further research to comprehend its genome evolution and the occurrence of mutations. These findings are pertinent to the development of testing approaches, therapeutics, and vaccine strategies.

show abstract

“…Increasing age has been well-studied among various ICU cohorts and found to be an independent risk factor. 39 Several studies have reported a stepwise increase in ICU mortality among individuals after the age of 60 years. 40 Increased age is associated with various underlying comorbidities in addition to their principal diagnosis mitigating the multimorbidity state, frailty, and polypharmacy, posing a challenge even prior admission.…”

Section: Discussionmentioning

confidence: 99%

The Pattern of Admission, Clinical Characteristics, and Outcomes Among Patients Admitted to the Intensive Care Unit of a Tertiary Hospital in Tanzania: A 5-Year Retrospective Review

Kassam,

Adebayo,

Matei

et al. 2023

PROM

View full text Add to dashboard Cite

Introduction Despite the implementation of complex interventions, ICU mortality remains high and more so in developing countries. The demand for critical care in Sub-Saharan Africa is more than ever before as the region experiences a double burden of rising rates of non-communicable diseases (NCD) in the background battle of combating infectious diseases. Limited studies in Tanzania have reported varying factors associated with markedly high rates of ICU mortality. Investigating the burden of ICU care remains crucial in providing insights into the effectiveness and challenges of critical care delivery. Material and Methods A single-center retrospective study that reviewed records of all medically admitted patients admitted to the ICU of the Aga Khan Hospital, Dar-es-Salaam, from 1st October 2018 to 30th April 2023. To define the population in the study, we used descriptive statistics. Patients’ outcomes were categorized based on ICU survival. Binary logistic regression was run (at 95% CI and p -value < 0.05) to identify the determinants for ICU mortality. Results Medical records of 717 patients were reviewed. The cohort was male (n=472,65.8%) and African predominant (n=471,65.7%) with a median age of 58 years (IQR 45.0–71.0). 17.9% of patients did not survive. The highest mortality was noted amongst patients with septic shock (29.3%). The lowest survival was noted amongst patients requiring three organ support (n=12,2.1%). Advanced age (OR 1.02,CI 1.00–1.04), having more than three underlying comorbidities (OR 2.50,CI 1.96–6.60), use of inotropic support (OR 3.58,CI 1.89–6.80) and mechanical ventilation (OR 9.11,CI 4.72–18.11) showed association with increased risk for mortality in ICU. Conclusion The study indicated a much lower ICU mortality rate compared to similar studies conducted in other parts of Sub-Saharan Africa. Advanced age, underlying multiple comorbidities and organ support were associated with ICU mortality. Large multi-center studies are needed to highlight the true burden of critical care illness in Tanzania.

show abstract

The impact of age on intensive care

Cited by 21 publications

References 80 publications

Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions

Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions

Genomic Surveillance and Mutation Analysis of SARS-CoV-2 Variants among Patients in Saudi Arabia

The Pattern of Admission, Clinical Characteristics, and Outcomes Among Patients Admitted to the Intensive Care Unit of a Tertiary Hospital in Tanzania: A 5-Year Retrospective Review

Contact Info

Product

Resources

About