The Impact of Age on Effects of Pre-hospital Initiation of High Bolus Dose of Tirofiban Before Primary Angioplasty for ST-Elevation Myocardial Infarction

Abstract

The effect of pre-hospital initiation of high bolus dose tirofiban on myocardial reperfusion, as determined by ST-segment resolution is highest in the elderly patients. However, this was associated with a trend towards more bleeding complications, resulting in a balanced clinical effect after 30-day follow-up. Future studies should evaluate whether the elderly STEMI patient may benefit from highly effective and safer antiplatelet therapy.

Antithrombotic therapy in the elderly and senile age: the consensus opinion of experts of the Russian Association of Gerontologists and Geriatricians and the National Society of Preventive Cardiology

“…Применение абциксимаба у пожилых пациентов с ОКСпST оказалось достаточно безопасным, но не имело преимуществ по эффективности в сравнении с плацебо [60]. Аналогичные результаты были получены для тирофибана [61].…”

Antithrombotic Therapy in Elderly and Senile Age: An Expert Consensus

“…Применение абциксимаба у пожилых пациентов с ОКС↑ST оказалось достаточно безопасным, но не имело преимуществ по эффективности в сравнении с плацебо [62]. Аналогичные результаты были получены для тирофибана [63].…”