The impact of age, weight and gender on BDNF levels in human platelets and plasma

Lommatzsch, Marek; Zingler, Doerte; Schuhbaeck, Katharina; Schloetcke, Katharina; Zingler, Christiana; Schuff‐Werner, P.; Virchow, J. Christian

doi:10.1016/j.neurobiolaging.2004.03.002

Cited by 737 publications

(521 citation statements)

References 70 publications

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“…Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011). Since lower serum or plasma BDNF levels are found in obesity (Araya et al, 2008;El-Gharbawy et al, 2006;Gray et al, 2006;Krabbe et al, 2007;Lommatzsch et al, 2005), compared to normal weight subjects, although opposite results also exist (Bus et al, 2011;Iughetti et al, 2011), our data suggest that carriers of one or two Met alleles in our study had decreased amount of the mature BDNF, possibly lower plasma BDNF levels, and therefore they had higher values of BMI and were more frequently obese. This speculation might be confirmed by the fact that weight gain, induced by antipsychotic drugs, is associated with BDNF serum levels in female schizophrenic patients, while carriers of the Met/Met genotype have lower BDNF levels than carriers of the Val allele (Zhang et al, 2008).…”

Section: Discussionmentioning

confidence: 51%

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Škledar¹,

Nikolac

Dodig-Ćurković

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Discussionmentioning

confidence: 51%

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Škledar¹,

Nikolac

Dodig-Ćurković

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Another possible cause of decrement of BDNF level with advancement of age is associated with prevalence of some neuro-endocrine or brain disorders like Parkinson's disease, which is also related to decrease dopamine concentration with age. Earlier studies also showed that BDNF has a negative correlation with age (Lommatzsch et al 2005). Improvement in levels of BDNF following yogic practice may be due to decrease stress level, shown by decrease cortisol levels, and improved HRV variables.…”

Section: Discussionmentioning

confidence: 88%

Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

Pal

Singh

Chatterjee

et al. 2014

AGE

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Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20-29, 30-39, and 40-49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.

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“…However, since the expression of BDNF mRNA does not reflect the rate of protein synthesized, 42 the relationship of BDNF rs6265 methylation with BDNF protein level may also be the result of the contribution of other elements, such as the expression of non-coding transcripts, affecting the level of BDNF protein by acting at a post-transcriptional level. 43,44 Moreover, since human platelets represent a main source of serum BDNF protein but not of BDNF mRNA, serum BDNF has been postulated not to originate from megakaryocyte precursor cells, while potential sources include CNS 41,45,46 ; indeed, it has been shown that BDNF can readily cross the brain-blood barrier. 47 The relationship between rs6265 methylation in PBMCs and serum BDNF levels is therefore compatible with a potential link between rs6265 methylation in PBMCs and in brain.…”

Section: Resultsmentioning

confidence: 99%

BDNF rs6265 methylation and genotype interact on risk for schizophrenia

et al. 2016

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Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val 66 Met), which creates or abolishes a CpG dinucleotide for DNA methylation. We found that methylation at the BDNF rs6265 Val allele in peripheral blood of healthy subjects is associated with hypoxia-related early life events (hOCs) and intermediate phenotypes for schizophrenia in a distinctive manner, depending on rs6265 genotype: in ValVal individuals increased methylation is associated with exposure to hOCs and impaired working memory (WM) accuracy, while the opposite is true for ValMet subjects. Also, rs6265 methylation and hOCs interact in modulating WM-related prefrontal activity, another intermediate phenotype for schizophrenia, with an analogous opposite direction in the 2 genotypes. Consistently, rs6265 methylation has a different association with schizophrenia risk in ValVals and ValMets. The relationships of methylation with BDNF levels and of genotype with BHLHB2 binding likely contribute to these opposite effects of methylation. We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia. The study of epigenetic changes in regions containing genetic variation relevant for human diseases may have beneficial implications for the understanding of how genes are actually translated into phenotypes.

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The impact of age, weight and gender on BDNF levels in human platelets and plasma

Cited by 737 publications

References 70 publications

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Age-related changes in cardiovascular system, autonomic functions, and levels of BDNF of healthy active males: role of yogic practice

BDNF rs6265 methylation and genotype interact on risk for schizophrenia

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