The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development

Šíma, Michal; Rössnerová, Andrea; Simova, Zuzana; Rössner, Pavel

doi:10.3390/jpm11010060

Cited by 25 publications

(14 citation statements)

References 132 publications

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“…A recent study has shown that a total of 25 miRNAs are deregulated in lung cancer as well as associated with air pollution exposure. It was suggested that miR-222, miR-21, miR-126-3p, miR-155, and miR-425 may serve as biomarkers for the assessment of risk factors for lung cancer in individuals who have been exposed to air pollution (Sima et al 2021). Besides various types of cancers, miRNAs are also deregulated in different diseases such as stroke, Alzheimer's disease, Parkinson's disease, and multiple sclerosis (Mahmoud et al 2021).…”

Section: Air Pollution and Mirnamentioning

confidence: 99%

Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis

Mukherjee

Dasgupta

Mishra

et al. 2021

Environ Sci Pollut Res

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Air pollution is a serious threat to our health and has become one of the major causes of many diseases including cardiovascular disease, respiratory disease, and cancer. The association between air pollution and various diseases has long been a topic of research interest. However, it remains unclear how air pollution actually impacts health by modulating several important cellular functions. Recently, some evidence has emerged about air pollution-induced epigenetic changes, which are linked with the etiology of various human diseases. Among several epigenetic modifications, DNA methylation represents the most prominent epigenetic alteration underlying the air pollution-induced pathogenic mechanism. Several other types of epigenetic changes, such as histone modifications, miRNA, and non-coding RNA expression, have also been found to have been linked with air pollution. Hypersensitivity pneumonitis (HP), one of the most prevalent forms of interstitial lung diseases (ILDs), is triggered by the inhalation of certain organic and inorganic substances. HP is characterized by inflammation in the tissues around the lungs’ airways and may lead to irreversible lung scarring over time. This review, in addition to other diseases, attempts to understand whether certain pollutants influence HP development through such epigenetic modifications.

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Section: Air Pollution and Mirnamentioning

confidence: 99%

Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis

Mukherjee

Dasgupta

Mishra

et al. 2021

Environ Sci Pollut Res

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“…A few examples are MIR-101, MIR-28, MIR-153, which are downregulated by ROS in breast cancer; MIR-200A and MIR-432-3P which are upregulated by ROS in esophageal cancer; MIR-7, upregulated in neuroblastoma and non-small cell lung cancer (53). In addition, several reports indicate that miRNA levels are affected by environmental pollutants and play a critical role in determining the tumor phenotype (58,59). er, in the onset of neurodegeneration, decreased cognitive functions, and psychiatric manifestations, including depression, anxiety and irritability (38).…”

Section: Heavy Metalsmentioning

confidence: 99%

Environmental pollutants and brain cancers: where do we stand

Migliaccio¹,

Williams²,

Caracciolo³

2021

Ann Res Oncol

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The global burden of Tumors of the Central Nervous System has increased in the past 25 years. Their prognosis is usually poor, and the less aggressive tumors can lead to severe cognitive and physical disabilities. The etiopathogenesis of CNS tumors is still largely unknown. Genetic factors and ionizing radiation are currently the only well-established risk factors for brain tumors. Several compounds present in the environment have been studied as possible causative agents of CNS tumors, often with inconclusive results. In this review, we focus the attention on certain categories of environmental pollutants for

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“…MicroRNAs are short non-coding RNAs playing a role in the epigenetic regulation of gene expression, acting at a posttranscriptional level to modulate the protein-encoding genes (12,13). MicroRNAs were first identified as novel biomarkers in the diagnosis and prognosis of serious diseases, including cancer, neurological disorders, and cardiovascular diseases (12)(13)(14). However, microRNAs have also been recognized as biomarkers of dose and early adverse effects in toxicological studies, showing a functional role in the environmental and occupational risk assessment (15).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression is associated with auditory dysfunction in workers exposed to ototoxic solvents and noise

Sisto

Moleti

Capone

et al. 2022

Front. Public Health

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This study is part of a project on early hearing dysfunction induced by combined exposure to volatile organic compounds (VOCs) and noise in occupational settings. In a previous study, 56 microRNAs were found differentially expressed in exposed workers compared to controls. Here, we analyze the statistical association of microRNA expression with audiometric hearing level (HL) and distortion product otoacoustic emission (DPOAE) level in that subset of differentially expressed microRNAs. The highest negative correlations were found; for HL, with miR-195-5p and miR-122-5p, and, for DPOAEs, with miR-92b-5p and miR-206. The homozygous (mut) and heterozygous (het) variants of the gene hOGG1 were found disadvantaged with respect to the wild-type (wt), as regards the risk of hearing impairment due to exposure to VOCs. An unsupervised artificial neural network (auto contractive map) was also used to detect and show, using graph analysis, the hidden connections between the explored variables. These findings may contribute to the formulation of mechanistic hypotheses about hearing damage due to co-exposure to noise and ototoxic solvents.

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The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development

Cited by 25 publications

References 132 publications

Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis

Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis

Environmental pollutants and brain cancers: where do we stand

MicroRNA expression is associated with auditory dysfunction in workers exposed to ototoxic solvents and noise

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