The Impact of Alloantibodies on Clinical VCA Outcomes and the Need for Immune Tolerance
Caitlin M. Blades,
Nalu Navarro-Alvarez,
Christene A. Huang
et al.
Abstract:The functional outcomes and restoration of form after vascularized composite allotransplantation (VCA) have exceeded the results that could be achieved with current autologous surgical techniques. However, the longevity of VCA grafts has been limited due to the development of donor-specific antibodies (DSAs), and chronic rejection and graft failure occur despite long-term immunotherapy. Furthermore, despite widespread consensus that these non-life-saving transplants are beneficial for select patients, the appl… Show more
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