The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy

Serhiyenko, Victoria; Hotsko, Мarta; Serhiyenko, Alexandr; Snitynska, Oksana; Serhiyenko, Ludmila; Segin, Volodymyr

doi:10.11648/j.ajim.20200805.11

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Considering that OS is significant for numerous DM complications, extensive studies on the antioxidant effect of various substances, including natural antioxidants of plant origin, were conducted [81]. Thus, the data indicating the role of various antioxidants (glutathione, coenzyme Q10, and α-lipoic acid) in restoring insulin sensitivity were obtained [91]. It was shown that α-and γ-tocopherol, retinol, β-cryptoxanthin [77], ascorbic acid [68], α-and β-carotene, lutein and zeaxanthin [86], and lycopene [51] significantly reduce DM complications.…”

Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidative damage to pancreatic β-cells, and endothelial dysfunction. The relationship between oxidative stress, carbonyl stress, and inflammation is described. The significance of oxidative stress reactions associated with hyperglycemia is considered in the context of the “metabolic memory” phenomenon. The results of our studies demonstrated significant ethnic and age-related variability of the LPO—antioxidant defense system parameters in patients with diabetes mellitus, which should be considered during complex therapy of the disease. Numerous studies of the effectiveness of antioxidants in diabetes mellitus of both types convincingly proved that antioxidants should be a part of the therapeutic process. Modern therapeutic strategies in the treatment of diabetes mellitus are aimed at developing new methods of personalized antioxidant therapy, including ROS sources targeting combined with new ways of antioxidant delivery.

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Section: Deactivation Of the Insulin Signaling Pathwaymentioning

confidence: 99%

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

2021

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“…Therapeutic strategies targeting post-translational modification of this protein have shown a pivotal potential in the treatment of diabetes, as well as showing the modulation of oxidative stress via SIRT3 has clearly been effective in this multifaceted disease [ 73 ]. Nowadays, the role of mitochondrial-targeting antioxidants able to diminish oxidative stress, alleviating vascular prognosis in patients with diabetes, is increasingly recognized [ 74 , 75 ], although multiple aspects still warrant further investigations. To date, the potential health benefits of whey in T2DM models are still little explored and additional future in-depth in vitro and in vivo studies on the role of each biomolecule and the complex interactions among them are critical to support the health potential of whey in the diabetic state.…”

Section: Discussionmentioning

confidence: 99%

Whey Improves In Vitro Endothelial Mitochondrial Function and Metabolic Redox Status in Diabetic State

et al. 2023

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Endothelial dysfunction plays a critical role in the progression of type 2 diabetes mellitus (T2DM), leading to cardiovascular complications. Current preventive antioxidant strategies to reduce oxidative stress and improve mitochondrial function in T2DM highlight dietary interventions as a promising approach, stimulating the deepening of knowledge of food sources rich in bioactive components. Whey (WH), a dairy by-product with a considerable content of bioactive compounds (betaines and acylcarnitines), modulates cancer cell metabolism by acting on mitochondrial energy metabolism. Here, we aimed at covering the lack of knowledge on the possible effect of WH on the mitochondrial function in T2DM. The results showed that WH improved human endothelial cell (TeloHAEC) function during the in vitro diabetic condition mimicked by treating cells with palmitic acid (PA) (0.1 mM) and high glucose (HG) (30 mM). Of note, WH protected endothelial cells from PA+HG-induced cytotoxicity (p < 0.01) and prevented cell cycle arrest, apoptotic cell death, redox imbalance, and metabolic alteration (p < 0.01). Moreover, WH counteracted mitochondrial injury and restored SIRT3 levels (p < 0.01). The SiRNA-mediated suppression of SIRT3 abolished the protective effects exerted by WH on the mitochondrial and metabolic impairment caused by PA+HG. These in vitro results reveal the efficacy of whey as a redox and metabolic modulator in the diabetic state and pave the way for future studies to consider whey as the source of dietary bioactive molecules with health benefits in preventive strategies against chronic diseases.

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“…Oxidative stress is a major contributing factor in the complications of type II diabetes (DMT2), prompting scientists to investigate the most effective diets to counteract oxidative stress. Notably, antioxidants such as glutathione, coenzyme Q10, and α-lipoic acid have been found to restore insulin sensitivity in DMT2 [ 63 ].…”

Section: Dietary Strategies To Counteract Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications

Caturano,

D’Angelo,

Mormone

et al. 2023

CIMB

128

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Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its associated complications. The imbalance between reactive oxygen species (ROS) production and the body’s antioxidant defence mechanisms leads to cellular damage and dysfunction. In diabetes, chronic hyperglycaemia and mitochondrial dysfunction contribute to increased ROS production, further exacerbating oxidative stress. This oxidative burden adversely affects various aspects of diabetes, including impaired beta-cell function and insulin resistance, leading to disrupted glucose regulation. Additionally, oxidative stress-induced damage to blood vessels and impaired endothelial function contribute to the development of diabetic vascular complications such as retinopathy, nephropathy, and cardiovascular diseases. Moreover, organs and tissues throughout the body, including the kidneys, nerves, and eyes, are vulnerable to oxidative stress, resulting in diabetic nephropathy, neuropathy, and retinopathy. Strategies to mitigate oxidative stress in diabetes include antioxidant therapy, lifestyle modifications, and effective management of hyperglycaemia. However, further research is necessary to comprehensively understand the underlying mechanisms of oxidative stress in diabetes and to evaluate the efficacy of antioxidant interventions in preventing and treating diabetic complications. By addressing oxidative stress, it might be possible to alleviate the burden of diabetes and improve patient outcomes.

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The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy

Cited by 4 publications

References 29 publications

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

Whey Improves In Vitro Endothelial Mitochondrial Function and Metabolic Redox Status in Diabetic State

Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications

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