1994
DOI: 10.1097/00007890-199403270-00015
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THE IMPACT OF AN ACUTE REJECTION EPISODE ON LONG-TERM RENAL ALLOGRAFT SURVIVAL (t1/2)1,2

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Cited by 424 publications
(188 citation statements)
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“…Although not reaching statistical significance, our results are consistent with previous studies that have shown an increasing number of AR episodes and later episodes of AR to be risk factors for graft loss [2,7,9,13,17,19,23]. We found a trend ( P = 0.096) toward an increased number of AR episodes per patient in those that developed deteriorating function.…”
Section: Discussionsupporting
confidence: 87%
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“…Although not reaching statistical significance, our results are consistent with previous studies that have shown an increasing number of AR episodes and later episodes of AR to be risk factors for graft loss [2,7,9,13,17,19,23]. We found a trend ( P = 0.096) toward an increased number of AR episodes per patient in those that developed deteriorating function.…”
Section: Discussionsupporting
confidence: 87%
“…In other recipients, however, episodes of AR did seem to lead to CR and graft loss. Review of the literature pointed to differences in AR in terms of number, timing, and/or severity as etiologies of the different long-term results of AR [l, 2,7,9,12,13,16,[17][18][19]23,24]. Utilizing an accurate assay (IoC1) for the assessment of renal function, the goal of our study was to identify what differences, if any, existed in episodes of AR that led to CR versus those in which AR did not seem to affect long-term function.…”
Section: Discussionmentioning
confidence: 99%
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“…However, despite recent advances in immunosuppression, acute rejection of the transplanted organ remains a major postoperative problem and is associated with a significantly increased risk for chronic graft rejection and graft loss. [1][2][3][4][5][6] In liver transplant recipients, current immunosuppressive regimens based on cyclosporine (CsA) or tacrolimus are still associated with acute rejection rates of 35% to 55% and 12-month graft and patient survival rates of only 70% to 80% and 80% to 85%, respectively. 7,8 In contrast to renal transplantation, no direct correlation between the occurrence of acute rejection and long-term graft function can be established.…”
mentioning
confidence: 99%
“…Such rejection episodes naturally eliminate the grafts from long-term survival analyses, such as the determination of transplant half-life, which only include grafts surviving the first post-transplant year. Matas et al [13] demonstrated how even a single episode of acute rejection influences the half-life of primary renal grafts.…”
Section: Nt Rod Udionmentioning
confidence: 99%