Wang et al.: Detailed Nursing Measures in Ensuring the Safety of Nursing in Operating RoomTo discuss the clinical application effect analysis of detailed nursing measures in ensuring the safety of nursing in the operating room is the objective. 140 patients who were admitted in the operating room of our hospital from December 2018 to December 2020 were randomly selected as the research objects. According to the computer random allocation method, they were divided into the control group and the experimental group, with 70 patients in each group. The control group was given routine nursing care and the intervention group was given detailed nursing care. The two groups were observed and compared the nursing quality scores, the rate of nurse-patient disputes and error rates, self-rating depression scale and self-rating anxiety scale scores, nursing satisfaction rate and complications. The results showed that compared with the control group, the intervention group had higher nursing quality scores, higher nursing satisfaction rate and postoperative self-rating depression scale and self-rating anxiety scale scores, lower nursing-patient disputes and complications and the differences were statistically significant (p<0.05). Detailed nursing measures improve the quality of care, relieve patient's anxiety and depression, increase patient satisfaction, significantly reduce postoperative complications and provide a guarantee for ensuring the safety of nursing care in the operating room.