The Impact of an Elevated Uric Acid Level on the Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates with Type 1 Diabetes: A Cross Sectional Study

Buksińska−Lisik, Małgorzata; Kwasiborski, Przemysław; Ryczek, Robert; Lisik, Wojciech; Mamcarz, Artur

doi:10.3390/jcm11092421

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…However, the prevalence of classical cardiovascular risk factors in overall T1D patients and pancreas-kidney recipients is very high, and they play an important role in the progression of coronary artery disease (CAD) [7][8][9]. Hypertension is observed in the majority of pancreas transplant candidates (both SPK and PTA) and presents likely the most common cardiovascular risk factor in this group of patients [4,10]. However, which blood pressure parameter is most closely associated with CAD in pancreas transplant candidates remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Ambulatory Blood Pressure Monitoring as a Useful Tool in the Cardiological Assessment of Pancreas Transplant Recipients with Type 1 Diabetes

Buksińska-Lisik,

Kwasiborski,

Ryczek

et al. 2023

Diagnostics

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Having the appropriate tools to identify pancreas recipients most susceptible to coronary artery disease (CAD) is crucial for pretransplant cardiological assessment. The aim of this study is to evaluate the association between blood pressure (BP) indices provided by ambulatory blood pressure monitoring (ABPM) and the prevalence of CAD in pancreas transplant candidates with type 1 diabetes (T1D). This prospective cross-sectional study included adult T1D patients referred for pretransplant cardiological assessment in our center. The study population included 86 participants with a median age of 40 (35–46) years. In multivariate logistic regression analyses, after adjusting for potential confounding factors, higher 24 h BP (systolic BP/diastolic BP/pulse pressure) (OR = 1.063, 95% CI 1.023–1.105, p = 0.002/OR = 1.075, 95% CI 1.003–1.153, p = 0.042/OR = 1.091, 95 CI 1.037–1.147, p = 0.001, respectively) and higher daytime BP (systolic BP/diastolic BP/pulse pressure) (OR = 1.069, 95% CI 1.027–1.113, p = 0.001/OR = 1.077, 95% CI 1.002–1.157, p = 0.043/OR = 1.11, 95% CI 1.051–1.172, p = 0.0002, respectively) were independently and significantly associated with the prevalence of CAD. Daytime pulse pressure was the strongest indicator of the prevalence of CAD among all analyzed ABPM parameters. ABPM can be used as a valuable tool to identify pancreas recipients who are most susceptible to CAD. We suggest the inclusion of ABPM in pretransplant cardiac screening in type 1 diabetes patients eligible for pancreas transplantation.

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Section: Introductionmentioning

confidence: 99%

Ambulatory Blood Pressure Monitoring as a Useful Tool in the Cardiological Assessment of Pancreas Transplant Recipients with Type 1 Diabetes

Buksińska-Lisik,

Kwasiborski,

Ryczek

et al. 2023

Diagnostics

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Hyperuricemia and Associated Factors in Adult Cardiac Patients in Western Oromia, Ethiopia

Addisu,

Sefew,

Milkit

et al. 2024

Nutr Metab Insights

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Background: Individuals who have hyperuricemia are at increased risk of cardiovascular diseases due to factors such as endothelial dysfunction, insulin resistance, and increased production of oxygen-free radicals. However, data on the prevalence and predictors of hyperuricemia among adults with cardiac diseases in Ethiopia are limited. Methods: A cross-sectional study was conducted on 269 participants at the Ambo University referral hospital from June to September, 2022. Participant demographics and relevant data were obtained through convenient sampling. Hyperuricemia was defined according to the manufacturer’s cutoff criteria. Data entry and analysis were conducted using SPSS 25. The association between the outcome and explanatory variables was assessed using a binary logistic regression model. Results: Of the study participants, 56.9% were male. The mean age of participants was 51.1 years (±15.8). The prevalence of hyperuricemia was 43.1% (95% CI: 37.1-49.1). Males presented a significantly higher prevalence of hyperuricemia compared to females (23.4% vs 19.7%, P = .026). Males had 2.9 times higher odds of hyperuricemia compared to females. Significant associations with the prevalence of hyperuricemia were found for individuals with a BMI ⩾30 kg/m2, age ⩾54 years, and male gender, with adjusted odds ratios (95% CI) of 2.3 (1.7-5.2), 2.9 (2.2-5.9), and 3.56 (2.1-12.8), respectively. Additionally, smoking, dyslipidemia, and waist circumference were also significantly associated with the prevalence of hyperuricemia. Conclusions: Nearly half of the cardiac patients in the study were diagnosed with hyperuricemia. These findings underscores the importance of early identification and treatment of hyperuricemia, alongside lifestyle and behavioral modifications, to maintain the quality of life in this specific population.

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The Impact of an Elevated Uric Acid Level on the Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates with Type 1 Diabetes: A Cross Sectional Study

Cited by 2 publications

References 62 publications

Ambulatory Blood Pressure Monitoring as a Useful Tool in the Cardiological Assessment of Pancreas Transplant Recipients with Type 1 Diabetes

Ambulatory Blood Pressure Monitoring as a Useful Tool in the Cardiological Assessment of Pancreas Transplant Recipients with Type 1 Diabetes

Hyperuricemia and Associated Factors in Adult Cardiac Patients in Western Oromia, Ethiopia

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