Artificial intelligence have very high capacities and capabilities in special education and have been strengthened and upgraded compared to the past. Especially in the field of education, teaching and learning, remarkable progress has happened and is happening. There are examples of artificial intelligence based on assistive technologies that can help people with special educational needs access and interact with educational content. In this chapter of the book, the opportunities and capabilities of artificial intelligence for people with special educational needs, particularly in teaching and learning process, have been introduced and analyzed. The types of assistive technologies based on artificial intelligence for disabled people have been explained. Also, in this chapter of the book, considering the importance of approaches and educational design models in the teaching and learning process of people with special educational and learning needs, the blended learning approach and model in special education have been introduced and its basic components and sub-components have been explained. At the end of the chapter of the book, case studies that have been done by author or by author’s supervision in this field have been mentioned.