The Impact of Anemia on QT Interval: A Population Based Study

Hünük, Burak; Çağaç, Özgür; Erdoğan, Okan; Kepez, Alper; Mutlu, Bülent; Değertekin, Muzaffer; Erol, Çetin

doi:10.1016/j.jacc.2013.08.434

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“…Recent studies have shown that Tp-Te, Tp-Te dis, Tp-Te/QT, and Tp-Te/QTc represent an arrhythmogenic tendency for ventricular arrhythmias and sudden cardiac death and as these parameters are relatively independent of heart rate, they have been found to be more useful than QT dispersion as markers in the prediction of ventricular arrhythmias. 7,13,18 The few studies in literature of the pediatric population have shown that Tp-Te and Tp-Te dis are prolonged in children with low iron reserve compared with the controls and a negative correlation has been found between these parameters and the serum ferritin level. It has also been reported that the Tp-Te/QTc ratio, which is known as the arrhythmogenic index, is prolonged when the iron reserve is low.…”

Section: Discussionmentioning

confidence: 99%

“…The shape of the T wave is a reflection of myocardial repolarization. Recent studies have shown that Tp-Te, Tp-Te dis, Tp-Te/QT, and Tp-Te/QTc represent an arrhythmogenic tendency for ventricular arrhythmias and sudden cardiac death and as these parameters are relatively independent of heart rate, they have been found to be more useful than QT dispersion as markers in the prediction of ventricular arrhythmias 7,13,18…”

Section: Discussionmentioning

confidence: 99%

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Does Iron Deficiency Affect the Heart in Children?

Demir¹,

Kayalı²,

Gökçebay³

2021

Journal of Pediatric Hematology/Oncology

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Introduction: It is well known that serum iron parameters are closely related to cardiovascular health. Iron deficiency may lead to significant cardiac problems, such as atrioventricular conduction abnormalities, and systolic and/or diastolic dysfunction. Studies related to the effect of iron deficiency on cardiac functions are limited in children. Therefore, the aim of this study was to evaluate the effect of low iron stores on cardiac repolarization parameters which are used to predict arrhythmia and cardiac functions.Materials and Methods: Onehundred thirty-five children 2 to 18 years of age without structural heart disease who were referred to the Pediatric Cardiology Department for various reasons such as chest pain, heart murmur, or evaluation before sports participation were evaluated prospectively. The cases were separated into 3 groups according to ferritin levels (group 1: ferritin <15 ng/mL [n = 48], group 2: ferritin 15 to 25 ng/mL [n = 51], and group 3: ferritin > 25 ng/mL [n = 36]). Evaluations were made with detailed 12-lead surface electrocardiography (ECG) and transthoracic echocardiogram. Cardiac repolarization parameters were measured from surface ECG and systolic functions, left ventricular wall diameters were evaluated from transthoracic echocardiogram.Results: Eighty-four (62.2%) girls and 51 (37.8%) boys are included in the study. The average age of the groups was similar. In children with low ferritin levels (group 1); Pw, Pw max, and Pw dis; QT, QTc, and QTc dis; Tp-Te, Tp-Te dis, Tp-Te/QT, and Tp-Te/QTc were significantly longer compared with the group 3 (P < 0.05). There was a negative correlation between ferritin level and Pw, P max, and Pw dis; QT, QT dis, QTc, and QTc dis; Tp-Te, Tp-Te dis, Tp-Te/QT, and Tp-Te/QTc (P < 0.05). No correlation was found between ferritin level and Pw min. There was no difference between the groups in respect of ejection phase indices, heart wall measurements, and end-diastolic diameter measurements. Conclusion:Iron deficiency may be related to the tendency of arrhythmias in children without structural heart disease. Therefore, careful evaluation of ECG parameters of healthy children with low iron stores, and follow up with intermittent monitoring is highly important.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%