The Impact of Aneurysmal Subarachnoid Hemorrhage on Functional Outcome

Kirkness, Catherine J.; Thompson, Jo Marie; Ricker, Barbara A.; Buzaitis, Ann; Newell, David W.; Dikmen, Sureyya; Mitchell, Pamela H.

doi:10.1097/01376517-200206000-00006

Cited by 25 publications

(25 citation statements)

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“…67 IADLs are more frequently impaired than ADLs with an estimated prevalence of 44% to 93%. 10,14,68,69 Deficits of visual memory and psychomotor functioning are significant predictors of IADL impairment. 12 Similar to ADLs, the instruments used to measure IADLs may not be sensitive to the subtle cognitive difficulties aSAH survivors may experience when performing tasks like driving and managing finances.…”

Section: Instrumental Activities Of Daily Livingmentioning

confidence: 99%

“…32,45,61,70 -74 Other studies have found less favorable results, demonstrating that only 6% to 17% of patients return to their previous occupation. 69,75,76 Some patients return to jobs with less responsibility, and oftentimes patients must work fewer hours as a result of fatigue and cognitive difficulties. 72,73,[75][76][77] Return to work and working ability are also influenced by the location of brain lesions.…”

Section: Return To Workmentioning

confidence: 99%

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Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Al-Khindi

Macdonald

Schweizer

2010

Stroke

665

478

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Background and Purpose-Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency characterized by the accumulation of blood in the subarachnoid space surrounding the brain. The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning. Methods-We reviewed all studies in the past 10 years that have focused on the effects of aSAH on cognition and day-to-day functioning. Results-Sixty-one empirical studies examining cognitive and functional outcome in patients with aSAH met inclusion criteria. Survivors of aSAH commonly experience deficits in memory, executive function, and language. These cognitive impairments interact to affect patients' day-to-day functioning, including activities of daily living, instrumental activities of daily living, return to work, and quality of life. Deficits in cognition and day-to-day functioning are further compounded by depression, anxiety, fatigue, and sleep disturbances. Conclusions-Much remains to be learned about the brain changes underlying cognitive and functional deficits, including the role of diffuse brain damage and secondary complications like vasospasm and elevated intracranial pressure. A consideration of these issues is necessary to obtain a better understanding of how aSAH affects cognition and day-to-day functioning in the long-term. (Stroke. 2010;41:e519-e536.)

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Section: Instrumental Activities Of Daily Livingmentioning

confidence: 99%

Section: Return To Workmentioning

confidence: 99%

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Al-Khindi

Macdonald

Schweizer

2010

Stroke

665

478

View full text Add to dashboard Cite

show abstract

“…use various measuring instruments in clinical (Hunt and Hess Scale, World Federation of Neurological Surgeons Scale, Glasgow Coma Scale, Fisher Scale) 7,24,25 and functional assessment (Barthel Index, Rankin Scale, Glasgow Outcome Scale, SF-36) 26,27 carried out both in the early and late period after the treatment of intracranial aneurysm.…”

Section: Discussionmentioning

confidence: 99%

Application of the functional capacity scale in the early assessment of functional efficiency in patients after aneurysm embolization: Preliminary reports

Ślusarz¹,

Biercewicz²,

Smarszcz³

et al. 2017

Adv Clin Exp Med

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“…The FSE, 27 which captures functional status domains important to aSAH survivors, 28 was also recorded. The FSE was administered at the same centralized telephone interview as the GOSE at Week 12.…”

Section: Cognitive Patient-relevant Outcome and Hcru End Pointsmentioning

confidence: 99%

Quality of Life and Healthcare Resource Use Associated With Angiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage

Macdonald

Hunsche²,

Schüler³

et al. 2012

Stroke

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Background and Purpose— In this analysis of data from a large clinical trial in aneurysmal subarachnoid hemorrhage, the impact of angiographic vasospasm (aVSP) on specific patient outcomes and inpatient healthcare resource use was assessed. Methods— This was a post hoc analysis of exploratory end points collected for 409 patients with aneurysmal subarachnoid hemorrhage in the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) trial. Central reviewers graded severity of aVSP as none, mild, moderate, or severe based on comparison of catheter angiograms obtained at baseline and 7 to 11 days after aneurysmal subarachnoid hemorrhage. Assessments of cognitive status (Mini-Mental State Examination) and patient-relevant outcomes (EuroQol total score and visual analog scale and Functional Status Examination) were administered at Week 12. The relationship between severity of aVSP and these end points as well as inpatient healthcare resource use (intensive care, general ward, and total hospital lengths of stay) was assessed using univariate and multivariate analyses. Results— Cognitive status and all patient-relevant outcome measures varied significantly ( P <0.0001) with severity of aVSP (mean for severe aVSP versus no aVSP, respectively: Mini-Mental State Examination, 18.0 versus 27.6; EuroQol total, 0.38 versus 0.74; EuroQol visual analog scale, 50.9 versus 75.5; Functional Status Examination, 20.5 versus 11.7). A significant inverse relationship with severity of aVSP was observed for total hospital days ( P =0.008) and days in the intensive care unit ( P <0.0001). On average, patients with severe aVSP stayed in the hospital 5 days longer than those with no aVSP. Conclusions— Severe aVSP is associated with poor cognition, worse patient-relevant outcomes, and greater inpatient healthcare resource use. Future studies assessing new aVSP treatments should include outcome measures that evaluate quality of recovery among survivors.

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The Impact of Aneurysmal Subarachnoid Hemorrhage on Functional Outcome

Cited by 25 publications

References 0 publications

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Application of the functional capacity scale in the early assessment of functional efficiency in patients after aneurysm embolization: Preliminary reports

Quality of Life and Healthcare Resource Use Associated With Angiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage

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