The impact of Angelina Jolie's (AJ) story on genetic referral and testing at an academic cancer centre.

Raphael, Jacques; Verma, Sunil; Hewitt, Paul; Eisen, Andrea

doi:10.1200/jco.2014.32.26_suppl.44

Cited by 8 publications

(6 citation statements)

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“…9 A recent Canadian study described a similar, dramatic increase in both counseling and testing when comparing referral patterns in the 6 months before the Jolie op-ed was published to the 6 month period following publication. 10 …”

Section: Discussionmentioning

confidence: 99%

BRCA1andBRCA2Mutation Testing in Young Women With Breast Cancer

et al. 2016

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Importance BRCA testing is recommended for young women diagnosed with breast cancer, but little is known about decisions surrounding testing and how results may influence treatment decisions in young patients. Objective To characterize genetic testing patterns of utilization and the impact on treatment decision-making among young women with breast cancer. Design Cross-sectional analysis of data collected between November 2006 and December 2014 as part of the Young Women's Breast Cancer Study, an ongoing prospective cohort study. Setting Eleven academic and community medical centers. Participants 897 women, age 40 and younger at breast cancer diagnosis. Main outcome measures 1) Frequency and trends in the utilization of BRCA testing; 2) how genetic information is used to make treatment decisions among women who test positive vs. test negative for a BRCA mutation. Results 87% of women reported BRCA testing by one year post-diagnosis, with the frequency of testing increasing among women diagnosed between 2006 and 2013 from 77% to 95%. Among untested women, 27% (32/117) did not report discussion of the possibility that they might have a mutation with a provider, and 37% (43 /117) were thinking of testing in the future. Approximately 30% (248/831) of women said that knowledge or concern about genetic risk influenced treatment decisions; among these women, 86% of mutation carriers, and 51% of non-carriers chose bilateral mastectomy. Fewer women reported that adjuvant treatment decisions were influenced by genetic risk concern. Conclusions and relevance Rates of BRCA1 and 2 mutation testing are increasing in young women with breast cancer. Given that knowledge/concern about genetic risk influences surgical decisions and may affect systemic therapy trial eligibility, all young breast cancer patients should be counseled and offered genetic testing, consistent with NCCN guidelines.

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Section: Discussionmentioning

confidence: 99%

BRCA1andBRCA2Mutation Testing in Young Women With Breast Cancer

et al. 2016

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“…In the Canadian study, a 90% increase among women correctly referred for breast cancer genetic counseling after media reports was observed. 15 In the UK study, the referrals more than doubled after Ms. Jolie's announcement, and remained at this level for at least 6 months thereafter. 11 We found that the media-related effect triggered awareness regardless of the level of personal involvement of the participants.…”

Section: Public Awareness In Breast Cancer/lebo Et Almentioning

confidence: 89%

“…To our knowledge, only a few publications to date have highlighted the media‐related impact on the health care sector, notably breast cancer. Two retrospective studies, one from Canada and one from the United Kingdom, demonstrated that referral rates for breast cancer were influenced by the media‐related publication of Ms. Jolie's prophylactic bilateral mastectomy in May 2013. In the Canadian study, a 90% increase among women correctly referred for breast cancer genetic counseling after media reports was observed .…”

Section: Discussionmentioning

confidence: 99%

“…Two retrospective studies, one from Canada and one from the United Kingdom, demonstrated that referral rates for breast cancer were influenced by the media‐related publication of Ms. Jolie's prophylactic bilateral mastectomy in May 2013. In the Canadian study, a 90% increase among women correctly referred for breast cancer genetic counseling after media reports was observed . In the UK study, the referrals more than doubled after Ms. Jolie's announcement, and remained at this level for at least 6 months thereafter .…”

Section: Discussionmentioning

confidence: 99%

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The Angelina effect revisited: Exploring a media‐related impact on public awareness

Lebo

Quehenberger

Kamolz

et al. 2015

Cancer

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BACKGROUND In 2013, Angelina Jolie's double mastectomy and publication of her personal treatment choice for BRCA1 positivity generated considerable media attention. To the authors’ knowledge, the current study is the first prospective survey conducted among the general public to measure a quantifiable media‐related effect on public awareness. METHODS The authors analyzed the changes in the general public's awareness of reconstructive options in breast cancer among 2 female population‐matched cohorts aged 18 to 65 years (1000 participants in each cohort) before (March 2013; poll 1) and after (June 2013; poll 2) the announcement of Ms. Jolie's mastectomy in May 2013. RESULTS There was an observed increase in public awareness: significantly more women from poll 2 were aware of reconstructive breast surgery being possible after breast cancer‐related mastectomy, notably with regard to autologous tissue and single‐stage reconstructions. Approximately 20% of the women in poll 2 (205 women) indicated that media coverage regarding Ms. Jolie affected their interest in breast cancer. A question that was exclusive to poll 2 revealed a preference for autologous (66.2%) versus implant‐based (8.2%) reconstructions, with the remainder indicating no preference (25.6%). None of the stratification variables were found to be associated with the above findings. CONCLUSIONS To the best of the authors’ knowledge, this is the first prospective study to demonstrate a statistically significant impact of a celebrity announcement on public awareness regarding breast cancer treatment. The results underscore the importance of a media‐related impact for professionals in the health care sector, which can serve as a tipping point for raising awareness and improving knowledge concerning a specific disease among the general public. Cancer 2015;121:3959–3964. © 2015 American Cancer Society.

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“…1 This announcement led to what oncologists refer to as “The Angelina Jolie Effect,” a more than doubling in the demand for BRCA testing in women who would not otherwise have gone for testing, but were at high risk for carrying the mutation based on family history and therefore should have undergone genetic testing. 2 In March 2015, Angelina Jolie published a second op-ed in The New York Times disclosing that she had undergone laparoscopic oophorectomy, removal of the ovaries to prevent ovarian cancer, and that she was receiving hormone replacement therapy to prevent the side-effects of premature menopause. 3…”

Section: Introductionmentioning

confidence: 99%

The Angelina Jolie Effect in Jewish Law: Prophylactic Mastectomy and Oophorectomy in BRCA Carriers

Grossman¹

2015

Rambam Maimonides Med J

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BackgroundFollowing the announcement of actress Angelina Jolie’s prophylactic bilateral mastectomies and subsequent prophylactic oophorectomy, there has been a dramatic increase in interest in BRCA testing and prophylactic surgery.ObjectiveTo review current medical literature on the benefits of prophylactic mastectomy and oophorectomy among BRCA-positive women and its permissibility under Jewish law.ResultsRecent literature suggests that in BRCA-positive women who undergo prophylactic oophorectomy the risk of dying of breast cancer is reduced by 90%, the risk of dying of ovarian cancer is reduced by 95%, and the risk of dying of any cause is reduced by 77%. The risk of breast cancer is further reduced by prophylactic mastectomy. Prophylactic oophorectomy and prophylactic mastectomy pose several challenges within Jewish law that call into question the permissibility of surgery, including mutilation of a healthy organ, termination of fertility, self-wounding, and castration. A growing number of Jewish legal scholars have found grounds to permit prophylactic surgery among BRCA carriers, with some even obligating prophylactic mastectomy and oophorectomy.ConclusionCurrent data suggest a significant reduction in mortality from prophylactic mastectomy and oophorectomy in BRCA carriers. While mutilation of healthy organs is intrinsically forbidden in Jewish law, the ability to preserve human life may contravene and even mandate prophylactic surgery.

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The impact of Angelina Jolie's (AJ) story on genetic referral and testing at an academic cancer centre.

Cited by 8 publications

References 0 publications

BRCA1andBRCA2Mutation Testing in Young Women With Breast Cancer

BRCA1andBRCA2Mutation Testing in Young Women With Breast Cancer

The Angelina effect revisited: Exploring a media‐related impact on public awareness

The Angelina Jolie Effect in Jewish Law: Prophylactic Mastectomy and Oophorectomy in BRCA Carriers

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