The impact of ankylosing spondylitis/axial spondyloarthritis on work productivity

Martindale, Jane; Shukla, Rudi; Goodacre, John

doi:10.1016/j.berh.2015.04.002

Cited by 53 publications

(38 citation statements)

References 58 publications

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“…The Work Productivity and Activity Impairment (WPAI) questionnaire is validated to assess the impact of a disease (here axSpA) on work productivity and on other daily activities [14, 15]. The Italian version of the WPAI was used to obtain the data in our study (from http://www.reillyassociates.net/WPAI_Translations.html) [16].…”

Section: Methodsmentioning

confidence: 99%

Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort

et al. 2016

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BackgroundSpondyloarthritis often affects young people, typically in their working years. The aim of our study was to investigate work productivity and its relationship with disease activity and physical functioning in Italian patients with axial spondyloarthritis (axSpA) with chronic back pain (CBP) for ≥3 months and ≤2 years, and onset < 45 years of age.MethodsBaseline absenteeism, presenteeism, work productivity loss (assessed by the Work Productivity and Activity Impairment questionnaire (WPAI)), and disease activity (assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)/Ankylosing Spondylitis Disease Activity Score (ASDAS)) and functional ability (assessed by the Bath Ankylosing Spondylitis Disease Functional Index (BASFI)) of patients with axSpA (rheumatologist’s diagnosis) included in the Italian section of the Spondyloarthritis Caught Early (SPACE) cohort were collected. Multivariate linear regression analysis was used to evaluate the associations between work productivity and disease activity/physical functioning.ResultsAbsenteeism in 51 patients with axSpA was low (8.3 %). A decrease in work productivity was related to an increase in disease activity. Disease activity was strongly correlated with absenteeism (p < 0.01), presenteeism (p < 0.01) and work productivity loss (p < 0.001). In addition, decreased work productivity was related to a decrease in functional ability. Physical functioning was correlated with absenteeism (p < 0.001), presenteeism (p < 0.05) and work productivity loss (p < 0.001).ConclusionsImpairment of work productivity was correlated with disease activity and physical functioning in Italian patients with axSpA with CBP for ≥3 months and ≤2 years, with onset <45 years of age.

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Section: Methodsmentioning

confidence: 99%

Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort

et al. 2016

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“…Participation in work has significant personal and societal impacts. Work is integral to self‐esteem and earnings from work are often necessary to finance healthcare costs . Loss of work productivity and unemployment are well described in patients with axSpA, with studies reporting up to a third of patients unable to work due to axSpA .…”

Section: Introductionmentioning

confidence: 99%

A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

et al. 2019

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Aim: Axial spondyloarthritis (axSpA) affects patients in the prime of their economic productivity. We aim to identify factors associated with poor work productivity in patients with axSpA in Singapore. Methods:A cross-sectional study was performed in two tertiary centers in Singapore. Consecutive adult patients ≥21 years fulfilling Assessment in SpondyloarthritisInternational Society (ASAS) 2009 criteria for axSpA were recruited. Data on social demographics, clinical, treatment modalities and patient-reported outcome measures (PROMs) were collected. Work productivity was assessed by the Work Productivity and Activity Impairment scale (WPAI:SpA). Factors associated with presenteeism, absenteeism, work productivity loss and activity impairment were evaluated. Results:A total of 156 patients with axSpA were included: 72.4% employed, 80.1% male, 86.5% Chinese, median (Q1:Q3) age and duration of illness 36.7 (28.7:47.9) years, and 6.3 (1.6:12.2) years respectively. The mean (SD) activity impairment was 28.2% (24.3%). Among employed patients, mean (SD) absenteeism, presenteeism and work productivity loss was 4.

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“…Symptoms typically begin in early adulthood, which is a critical time for education, career, social networks and development of personal identity in general. Consequently, axSpA can significantly impact on mental health, quality of life and work productivity over the life course, at costs to the individual and the economy [2,3].…”

Section: Introductionmentioning

confidence: 99%

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

Zhao¹,

Pittam²,

Harrison³

et al. 2020

Preprint

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Background . Delay to diagnosis in axial spondyloarthritis (axSpA) is longer than many other rheumatic diseases. Prolonged delay has been shown to associate with poorer outcomes including functional impairment and quality of life. Our aims were to describe 1) global variation in delay to diagnosis, 2) factors associated with delay, and 3) differences in diagnostic delay between axSpA and psoriatic arthritis (PsA).Methods . We searched Medline, PubMed, EMBASE and Web of Science using a predefined protocol in accordance with PRISMA guidelines. Delay to diagnosis was defined as years between age at symptom onset and age at diagnosis. We pooled mean diagnostic delay using random-effects inverse variance meta-analysis. We examined variations in pooled estimates using pre-specified subgroup analyses and sources of heterogeneity using meta-regression.Results. A total of 54 studies reported mean diagnostic delay in axSpA patients. The pooled mean delay was 6.8 years (95% confidence interval 6.2 to 7.3) with high levels of heterogeneity. Delay to diagnosis did not improve over time when stratifying results by year of publication. Studies from high-income countries (defined by the World Bank) reported longer delay than those from middle-income countries. Factors consistently reported to be associated with longer delay were: lower education levels, younger age at symptom onset and absence of extra-articular manifestations. Pooled estimate for diagnostic delay from 8 PsA studies was significantly shorter, at 2.6 years (95%CI 1.6 to 3.6).Conclusion. For axSpA patients, delay to diagnosis remains unacceptably prolonged in many parts of the world, although some countries have reported remarkable improvements. Patient factors (education) and disease presentation (age at onset and extra-articular manifestations) should inform awareness campaigns to improve delay. Targets for improvement should aim to resemble delays in other spondyloarthritis patients.

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The impact of ankylosing spondylitis/axial spondyloarthritis on work productivity

Cited by 53 publications

References 58 publications

Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort

Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort

A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

Systematic review and meta-analysis of diagnostic delay in axial spondyloarthritis

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