The impact of anti-Müllerian hormone (AMH) on multiple pronuclei (PN) presence and oocyte maturity in ICSI treatments

Sayme, Nabil; Kljajić, Marija; Krebs, Thomas; Maas, D.

doi:10.1080/09513590.2019.1706080

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…The possible reason may be that although higher AFC could lead to more retrieved oocytes, they also contributed to higher proportion of small immature oocytes on the retrieval day, which may result in lower oocyte maturity rate. Because Anti-Mullerian Hormone (AMH), which is another indicator of ovarian reserves and strong positively with AFC, also had higher correlation coefficients with immature oocytes than mature oocytes [27,28].…”

Section: Comparisons Of Results Between Ours and Previous Studiesmentioning

confidence: 99%

The ovulation trigger–OPU time interval of different ovarian protocols in ART: a retrospective study

Shen

Long

Guo

et al. 2020

Arch Gynecol Obstet

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Purpose To explore the trends of oocyte and pregnancy outcomes over the ovulation trigger-OPU (oocyte pickup) time interval in four mainly used COH protocols. Methods This retrospective study was conducted between January 2013 and July 2018. The IVF/ICSI cycles of the patients with normal ovarian reserve were included. The number of total patients was 4673, which consisted of long agonist protocol (n = 819), short agonist protocol (n = 1703), mild stimulation protocol (n = 1627), and GnRH antagonist protocol (n = 524). The primary outcome was mature oocyte rate. Results The ovulation trigger-OPU time interval and COH protocol were related to cycles with > 80% MII oocytes. Four protocols showed apparently different trends of retrieved oocyte rate and mature oocyte rate over the ovulation trigger-OPU time interval, and the long agonist protocol had the most delayed time interval than other three COH protocols in retrieving more than 60% oocytes (35.

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Section: Comparisons Of Results Between Ours and Previous Studiesmentioning

confidence: 99%

The ovulation trigger–OPU time interval of different ovarian protocols in ART: a retrospective study

Shen

Long

Guo

et al. 2020

Arch Gynecol Obstet

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“…AMH signi cantly correlates with the presence of multiple pronuclei in the zygote. The presence of multiple pronuclei increased when AMH levels were higher [24]. Supplementation of exogenous LH activity to ovarian stimulation may be associated with lower prevalence of 3PN zygotes in IVF cycles, but not in ICSI cycles [1].…”

Section: Discussionmentioning

confidence: 99%

Effect of three pro-nuclei (3PN) on the outcomes of PGT

Jiang

Yuan

et al. 2023

Preprint

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Aims To explore the influence of 3PN on outcomes in preimplantation genetic testing (PGT) cycles. Methods This was a retrospective study of patients undergoing PGT treatment included 139 PGT for aneuploidy (PGT-A) cycles and 285 cycles PGT for monogenic/single gene defects and/or chromosomal structural rearrangements (PGT-M/SR). The 424 PGT cycles were divided into two groups as follows: group 1 included 343 cycles with no 3PN zygotes and group 2 included 81 cycles with 3PN zygotes. 3PN cycle rate was compared between PGT-A and PGT-M/SR cycles. The outcomes of PGT were analyzed between the two groups. Results The female and male's age were significantly higher in PGT-A than PGT-M/SR cycles. Whereas 3PN rate was not significantly different between the two groups. The number of retrieved oocytes was significantly higher in 3PN group than Non 3PN group (13.98 ± 7.10 vs. 10.89 ± 6.65; P < 0.05). The MII oocyte rate, 2PN fertilizaion rate, D3 high embryo rate, biopsy blastocyst rate, per oocyte utilization and D5 blastocyst rate were significantly lower in 3PN group than Non 3PN group (P < 0.05). The results of chromosomal mosaic rate was significantly higher in 3PN group than Non 3PN group (16.3 vs. 11.9; P < 0.05). Conclusions No correlation was observed between 3PN formation rate and PGT-A or PGT-M/SR cycles. The occurrence of 3PN seems to impair the developing blastocyst and interfere with good embryo formation rate and mosaic rate in PGT. But the occurrence of 3PN does not seem to impair the euploid rate and aneuploid rate.

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The impact of anti-Müllerian hormone (AMH) on multiple pronuclei (PN) presence and oocyte maturity in ICSI treatments

Cited by 2 publications

References 27 publications

The ovulation trigger–OPU time interval of different ovarian protocols in ART: a retrospective study

The ovulation trigger–OPU time interval of different ovarian protocols in ART: a retrospective study

Effect of three pro-nuclei (3PN) on the outcomes of PGT

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