The impact of antipsychotic side effects on attitudes towards medication in people with schizophrenia and related disorders

Chiang, Yan Ling; Klainin‐Yobas, Piyanee; Ignacio, Jeanette; Chng, Cecilia Mui Lee

doi:10.1111/j.1365-2702.2010.03659.x

Cited by 10 publications

(14 citation statements)

References 35 publications

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“…Tiredness, tension, depression, restlessness, initial insomnia (difficulty falling asleep), and difficulty staying awake during the day, sleeping too much and feeling sick were the most prevalent individual ADRs in this study. Similar to this research, some other studies had found psychic and extrapyramidal ADRs to be most prevalent 8,30,31 and anticholinergic ADRs least prevalent. 8 Likewise, tiredness, memory problems, tension, depression, restlessness, and concentration problems were among the most prevalent ADRs of Day et al's 31 findings.…”

Section: Magnitude and Nature Of Adrssupporting

confidence: 90%

“…Similar to this research, some other studies had found psychic and extrapyramidal ADRs to be most prevalent 8,30,31 and anticholinergic ADRs least prevalent. 8 Likewise, tiredness, memory problems, tension, depression, restlessness, and concentration problems were among the most prevalent ADRs of Day et al's 31 findings. However, inconsistent with the Day et al study, anticholinergic ADRs including dry mouth and blurred vision were less prevalent in this study, which could be attributed to the sparse prescription or availability of anticholinergic drugs in Eritrea.…”

Section: Magnitude and Nature Of Adrssupporting

confidence: 90%

“…6,7 However, adverse drug reactions (ADRs) of these products are the major challenges in treating patients with psychotic disorders. [8][9][10][11] Extrapyramidal symptoms, sedation, sexual-dysfunction, anticholinergic effects, weight gain, memory and concentration problems, cardiovascular, gastrointestinal, and metabolic adverse effects are the commonly reported ADRs of antipsychotics. 1,-12-17 ADRs can occur at first dose, during prolonged administration of a drug and/or single or combination therapy of two or more drugs.…”

Section: Introductionmentioning

confidence: 99%

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<p>Magnitude, Nature, and Risk Factors of Adverse Drug Reactions Associated with First Generation Antipsychotics in Outpatients with Schizophrenia: A Cross-Sectional Study</p>

Bahta

Berhe

Russom

et al. 2020

IPRP

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Background: ADRs to antipsychotics are amongst the major challenges in the treatment of patients with psychotic disorders. The extent of patient-reported ADRs assessed in many studies using standardized scales is found to be inconsistent. However, there is a paucity of such research in Eritrea. The aim of the study is therefore to determine the magnitude, nature, and the possible risk factors associated with ADRs of the first generation antipsychotics in outpatients with schizophrenia at Saint Mary Neuro-Psychiatric National Referral Hospital in Asmara, Eritrea, using the LUNSERS self-rating scale. Methods: A cross-sectional, descriptive and analytical study design utilizing a quantitative approach was employed. Data were collected from patients' self-administered questionnaires, interviews, and medical records. The collected variables were analyzed using SPSS 22.0 with descriptive statistics, correlation, t-tests, ANOVA, and multiple regression. Statistical significance was tested at P-value<0.05. Results: In this study, 93.8% of the research participants experienced at least one ADR. LUNSERS total mean score of the relevant items was 28.01 (SD=18.46) with 24.7% of the study participants scoring medium-to-high. The prevalence of the categories of ADRs was psychic (91.3%), autonomic (78.1%), extra-pyramidal (76.9%), miscellaneous (66.5%), hormonal (58.3%), anti-cholinergic (44.2%), and allergic reactions (44.2%). At multivariate level, factors significantly and positively associated with total ADR score were smoking (P=0.028) and being at secondary educational level (P=0.015). Conclusion: There was high prevalence of ADRs with moderate-to-high overall ADR scores in a significant number of patients. The most frequently reported ADRs were psychic, autonomic, extra-pyramidal, hormonal, and miscellaneous. Smoking and secondary level of education were found to be the main determinants of ADRs.

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Section: Magnitude and Nature Of Adrssupporting

confidence: 90%

Section: Magnitude and Nature Of Adrssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Magnitude, Nature, and Risk Factors of Adverse Drug Reactions Associated with First Generation Antipsychotics in Outpatients with Schizophrenia: A Cross-Sectional Study</p>

Bahta

Berhe

Russom

et al. 2020

IPRP

View full text Add to dashboard Cite

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“…The term "adverse effects" is preferred to the euphemistic term "side effects" to draw attention to the medically signi fi cant as well as unpleasant nature of many of these, as well as to their strong association with non-adherence to recommended treatment [ 40,78 ] . Common adverse effects include excessive sedation, fatigue, decreased alertness, decreased or slowed motility, and an overall burden of nonspeci fi c effects of the "medicated state."…”

Section: Adverse Effectsmentioning

confidence: 99%

Antipsychotic Agents

Baldessarini

2012

Chemotherapy in Psychiatry

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“…Menstrual dysfunction is common in women with schizophrenia and is at least partially accounted for by antipsychotic induced hyperprolactinaemia (Chiang et al, 2011;Magharious et al, 1998;Prentice and Deakin, 1992;Smith et al, 2002;Wieck and Haddad, 2003). Irregular menses are usually associated with anovulation (Munro et al, 2011) and therefore lack of rise in oestradiol levels in the luteal phase of the menstrual cycle.…”

Section: Introductionmentioning

confidence: 99%

Menstrual cycle characteristics in women with persistent schizophrenia

Gleeson

Worsley

Gavrilidis

et al. 2015

Aust N Z J Psychiatry

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Objective: Oestradiol has been implicated in the pathogenesis of schizophrenia. Women with schizophrenia often suffer with menstrual dysfunction, usually associated with low oestradiol levels, but whether menstrual dysfunction has an effect on their psychiatric symptoms is not well researched. The aim of this study is to document the menstrual characteristics of women with chronic schizophrenia with focus upon menstrual regularity, menstrual cycle length and menstrual symptoms. To determine which patient characteristics are associated with irregular menses and whether irregular menses are associated with the severity of psychotic symptoms, menstrual symptoms or depressive symptoms. Method:Cross-sectional analyses using baseline data of women enrolled in a clinical trial. Inclusion criteria include Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, Text Revision diagnosis of schizophrenia, schizoaffective or schizophreniform disorder; aged between 18 and 51 years; residual symptoms of psychosis despite treatment with a stable dose of antipsychotic medication for at least 4 weeks. Menstrual cycle characteristics including regularity, cycle length and menstrual associated symptoms were documented. Symptoms of schizophrenia were measured using Positive and Negative Syndrome Scale, cognition was measured using Repeatable Battery for the Assessment of Neuropsychological Status and depression was assessed using the Montgomery-Asberg Depression Rating Scale. Blood samples were collected at baseline for hormone assays. Results:Of the 139 women, 77 (55.4%) had regular menses, 57 (41%) had irregular menses and 5 (3.6%) women had missing data on their menstrual cycle. Use of atypical antipsychotics associated with hyperprolactinaemia was positively associated with irregular menses (odds ratio = 4.4, 95% confidence interval = [1.8, 10.9], p = 0.001), while age more than 30 years was negatively associated (odds ratio = 0.3, 95% confidence interval = [0.1, 0.6], p = 0.004). Women with irregular cycles had significantly lower oestradiol levels than women with regular cycles (213.2 ± 25.0 vs 299.0 ± 27.3, p = 0.03), but there was no difference in Positive and Negative Syndrome Scale, Montgomery-Asberg Depression Rating Scale or Repeatable Battery for the Assessment of Neuropsychological Status between those with regular and irregular cycles. The most common menstrual associated symptoms were decrease in mood with the menstrual cycle (64.8%), bloating (64.8%), cramps (59.7%), back pain (37.6%) and worsening of psychosis symptoms (32.4%). Conclusion:Regular menses are associated with higher oestradiol levels and higher rates of cyclical mood symptoms but are not associated with Positive and Negative Syndrome Scale scores. Understanding the effect the menstrual cycle can have on psychiatric illness, such as premenstrual exacerbations, is important for the holistic care of women with schizophrenia.

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The impact of antipsychotic side effects on attitudes towards medication in people with schizophrenia and related disorders

Abstract: Findings guide the development of appropriate nursing interventions that aim to alleviate side effects, reduce negative attitudes towards medication and prevent compliance problems.

Cited by 10 publications

References 35 publications

<p>Magnitude, Nature, and Risk Factors of Adverse Drug Reactions Associated with First Generation Antipsychotics in Outpatients with Schizophrenia: A Cross-Sectional Study</p>

<p>Magnitude, Nature, and Risk Factors of Adverse Drug Reactions Associated with First Generation Antipsychotics in Outpatients with Schizophrenia: A Cross-Sectional Study</p>

Antipsychotic Agents

Menstrual cycle characteristics in women with persistent schizophrenia

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