2024
DOI: 10.1101/2024.05.10.24307165
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The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studies

Madison Bailey,
Zlatomira Georgieva Ilchovska,
Akram A. Hosseini
et al.

Abstract: BackgroundAlzheimer’s disease (AD) is the most prevalent form of dementia, exerting substantial personal and societal impacts. The apolipoprotein E (APOE) ε4 allele is a known genetic factor that increases the risk of AD, contributing to more severe brain atrophy and exacerbated symptoms.PurposeWe aim to provide a comprehensive review of the impacts of the APOE ε4 allele on brain atrophy in AD and mild cognitive impairment (MCI) as a transitional stage of AD.MethodsWe performed a coordinate-based meta-analysis… Show more

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