This chapter focuses on understanding the caregiving experience and its interdependence with primary caregivers' mental health, physical health, and perceived self-efficacy over time while providing long-term care for children with neurodevelopmental disorders (NDDs). Thus, it is imperative to prepare the primary caregivers to provide effective care, as well as look after one's own physical and mental health. The primary objective of the study was to explore the factors influencing self-efficacy among caregivers through a mixed-method research design. To understand the level of self-efficacy among primary care providers of children with NDD, the caregiver self-efficacy scale (CSES-8) was administered, and to explore the factors influencing caregiving self-efficacy, one-on-one interviews were conducted. Comprehension of the factors influencing self-efficacy would enable healthcare and other allied healthcare providers to effectively address the supportive needs and improve positive resources for the caregivers in personal, behavioral, and environmental domains.