The Impact of Bariatric Surgery in the Epigenetics of Patients with Obesity and Type 2 Diabetes Mellitus: A Prospective Study of the DNA Methylation Remodeling in Adipose Tissue

Zerrweck, Carlos; Sanchez, Ernesto Sola; Martínez, Guillermo; Baca, Paulina; Maydón, Hernán; Sepúlveda, Elisa; Martínez, Angélica; Barajas‐Olmos, Francisco; Centeno, Federico

doi:10.1016/j.soard.2016.08.065

Cited by 1 publication

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“…A BMI of 35 kg/m 2 or higher with one or more ill conditions is the inclusion criterion for bariatric surgery, according to the national institute of health (NIH) [ 70 ]. Bariatric surgery provides a chance to investigate the epigenetic mechanism linked with an improved metabolic status related to weight loss [ 71 ].…”

Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

“…The impact of Bariatric Surgery on the epigenetics of patients with obesity and T2DM has been evaluated by the global profiles of DNA methylation in subcutaneous adipose tissue of Mexican populations [ 71 ]. The authors found significant DNA methylation remodeling in adipose tissue six months after the surgery, which was correlated with reductions in body weight and biochemical markers [ 71 ]. Whole blood DNA methylation analyses before and after biliopancreatic diversion with duodenal switch (BPD-DS), a metabolic bariatric operation, in obese women showed differentially methylated genes related to diabetic and inflammatory functions (ABCF1, FKBP1A, IFIT2, HTT) [ 72 ].…”

Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

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Epigenetic Regulation of Obesity-Associated Type 2 Diabetes

Ibrahim

2022

Medicina

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Obesity is becoming more widespread, and epidemics of this condition are now considered present in all developed countries, leading to public health concerns. The dramatic increases in obesity, type 2 diabetes mellitus (T2DM), and related vascular difficulties are causing a public health crisis. Thus, it is imperative that these trends are curbed. Understanding the molecular underpinnings of these diseases is crucial to aiding in their detection or even management. Thus, understanding the mechanisms underlying the interactions between environment, lifestyle, and genetics is important for developing effective strategies for the management of obesity. The focus is on finding the vital role of epigenetic changes in the etiology of obesity. Genome and epigenome-wide approaches have revealed associations with T2DM. The epigenome indicates that there is a systematic link between genetic variants and environmental factors that put people at risk of obesity. The present review focuses on the epigenetic mechanism linked with obesity-associated T2DM. Although the utilization of epigenetic treatments has been discussed with reference to certain cancers, several challenges remain to be addressed for T2DM.

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Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

Section: Bariatric Surgery and Epigenetics Of Patients With Obesity-a...mentioning

confidence: 99%

See 1 more Smart Citation

Epigenetic Regulation of Obesity-Associated Type 2 Diabetes

Ibrahim

2022

Medicina

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show abstract

The Impact of Bariatric Surgery in the Epigenetics of Patients with Obesity and Type 2 Diabetes Mellitus: A Prospective Study of the DNA Methylation Remodeling in Adipose Tissue

Cited by 1 publication

References 0 publications

Epigenetic Regulation of Obesity-Associated Type 2 Diabetes

Epigenetic Regulation of Obesity-Associated Type 2 Diabetes

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