The impact of bariatric surgery on liver enzymes in people with obesity: A 5-year observational study

Elhelw, Omar; Ragavan, Sharanniyan; Majeed, Waseem; Alkhaffaf, Bilal; Mohammed, Noor; Senapati, Siba; Ammori, Basil J.; Robinson, James Andrew; Syed, Akheel A.

doi:10.1016/j.surge.2023.07.006

Cited by 6 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, the most effective treatments are represented by bariatric surgery in young patients [ 53 ], to avoid the development of metabolic syndrome and liver failure. It should be underlined, the high risk of liver steatosis also after liver transplants [ 54 , 55 ], so QUS may represent a safe and efficient tool to monitor the results of bariatric surgery or the health of the liver graft.…”

Section: Discussionmentioning

confidence: 99%

Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions

Rocca,

Komici,

Brunese

et al. 2024

Radiol med

View full text Add to dashboard Cite

Liver steatosis is the most common chronic liver disease and affects 10–24% of the general population. As the grade of disease can range from fat infiltration to steatohepatitis and cirrhosis, an early diagnosis is needed to set the most appropriate therapy. Innovative noninvasive radiological techniques have been developed through MRI and US. MRI-PDFF is the reference standard, but it is not so widely diffused due to its cost. For this reason, ultrasound tools have been validated to study liver parenchyma. The qualitative assessment of the brightness of liver parenchyma has now been supported by quantitative values of attenuation and scattering to make the analysis objective and reproducible. We aim to demonstrate the reliability of quantitative ultrasound in assessing liver fat and to confirm the inter-operator reliability in different respiratory phases. We enrolled 45 patients examined during normal breathing at rest, peak inspiration, peak expiration, and semi-sitting position. The highest inter-operator agreement in both attenuation and scattering parameters was achieved at peak inspiration and peak expiration, followed by semi-sitting position. In conclusion, this technology also allows to monitor uncompliant patients, as it grants high reliability and reproducibility in different body position and respiratory phases.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions

Rocca,

Komici,

Brunese

et al. 2024

Radiol med

View full text Add to dashboard Cite

show abstract

“…We performed a retrospective observational analysis of patients who had undergone bariatric surgery in a National Health Service (NHS) university teaching hospital in Northwest England. We identified patients for the current study from a pre-existing database of patients who had undergone bariatric surgery over a three-year period [ 13 ]. Patients were followed up over a two-year period at 4, 12, and 24 months, and were included if they had a minimum of two serum urate measurements, one pre- and one post-operative level.…”

Section: Methodsmentioning

confidence: 99%

Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study

Mills,

Woolley,

Ammori

et al. 2024

OBES SURG

Self Cite

View full text Add to dashboard Cite

Background Obesity is a risk factor for hyperuricemia and gout, while weight reduction can reduce urate levels. The aim of this study was to examine the effect of bariatric surgery on longitudinal serum urate levels. Methods We performed a retrospective observational study of 283 patients who had undergone bariatric surgery [237 (83.7%) gastric bypass, 34 (12.0%) sleeve gastrectomy and 12 (4.2%) gastric banding] and were followed up for 2 years. The results shown represent mean (standard deviation). Results Bariatric surgery was associated with significant reduction in serum urate from baseline level of 0.343 (0.086) mmol/L to 0.296 (0.076) mmol/L (p < 0.001) at 12 months and 0.286 (0.073) mmol/L (p < 0.001) at 24 months, including in men and women, and in patients with or without diabetes. Patients with elevated urate levels at baseline, who comprised 27.2% of the total cohort, achieved reduction in levels by 4 months. Conclusion Bariatric surgery leads to significant reduction in serum urate levels at 12 and 24 months. This could reduce incidence of gout and need for prophylactic medication(s). Graphical Abstract

show abstract

“…The World Health Organization (WHO) criteria for metabolic syndrome were adapted for the definition of metabolic syndrome in this study (Table 1) [24]. Patients were identified from an existing bariatric surgery database and clinical information was extracted from electronic patient records [25]. After excluding patients with insufficient baseline information to categorise the presence or absence of metabolic syndrome; 333 patients were included in the study and categorised into Group A (metabolic syndrome absent) and Group B (metabolic syndrome present).…”

Section: Methodsmentioning

confidence: 99%

Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study

Ragavan,

Elhelw,

Majeed

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

Aim: Whilst bariatric surgery is the most effective treatment for severe obesity, the aim of this study was to evaluate whether postoperative weight loss is similar in patients with or without metabolic syndrome. Methods: We performed a 5-year observational retrospective comparative cohort analysis of bariatric surgery in 333 patients (72% women) without (Group A, n = 133) or with (Group B, n = 200) metabolic syndrome at baseline. Results: Overall mean (SD) baseline body mass index was 51.7 (7.5) with no significant difference between groups. Overall mean percent total weight loss (%TWL) was 31.9% by 24 months after surgery. Although %TWL was greater in Group A (34.9%) than in Group B (30.2%, p = 0.006) at 24 months, there were no significant differences between groups subsequently up to 60 months of follow-up. Systolic and diastolic blood pressures and lipid profiles improved in both groups. In patients with metabolic syndrome at baseline, mean HbA1c reduced by 36.4% at 12 months and was sustained over the study period. Conclusions: We report that bariatric surgery results in comparable long-term weight loss in patients with or without metabolic syndrome alongside expected improvements in metabolic comorbidities.

show abstract

The impact of bariatric surgery on liver enzymes in people with obesity: A 5-year observational study

Cited by 6 publications

References 23 publications

Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions

Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions

Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study

Weight Loss Following Bariatric Surgery in People with or without Metabolic Syndrome: A 5-Year Observational Comparative Study

Contact Info

Product

Resources

About