The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing

Shadid, Iskander L.C.; Brustad, Nicklas; Lu, Michael W.; Chawes, Bo; Bisgaard, Hans; Zeiger, Robert S.; O’Connor, George T.; Bacharier, Leonard B.; Guchelaar, Henk‐Jan; Litonjua, Augusto A.; Weiss, Scott T.; Mirzakhani, Hooman

doi:10.1016/j.ajcnut.2023.04.019

Cited by 5 publications

(2 citation statements)

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“…In this study, the concentration of VitD in pregnant women less than 20 weeks of gestation gradually increased, remained stable at a relatively high concentration between weeks 20 and 30, and decreased with increasing gestational weeks in women with gestational age greater than 30 weeks. It maybe due to the following reasons: (1) although the demand for VitD increased during pregnancy, the required amount had not yet reached a very high concentration in early pregnancy, and the absorption and metabolism capacity of VitD in pregnant women gradually increases in the early stages of pregnancy ( 31 , 32 ). (2) Due to local prenatal care recommendations, pregnant women were advised to start regular VitD supplements around week 20 of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Three-stage pattern of rapid increase, plateau, and subsequent decline in vitamin D concentration during pregnancy among Chinese women: a large-scale survey

Wang,

Zhang,

et al. 2023

Front. Nutr.

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BackgroundThere is an incomplete understanding of fluctuations in vitamin D (VitD) concentration during pregnancy among Chinese women. Furthermore, previous research has yielded conflicting results in this area. This study aims to investigate the changes in VitD status and deficiency in Chinese pregnant women across various age groups, gestational weeks, and as well as seasonal variations through conducting a large-scale survey.MethodsA toal of 11,220 Chinese pregnant women between 2021 and April 2023 were included in this study. Generalized additive models (GAM), stratified analysis, and restricted cubic splines (RCS) were used to analyze changes in VitD status and deficiency risk during pregnancy.ResultsOf the participants, 45.2% had deficient concentration of 25-hydroxyvitamin D. VitD concentration and deficiency rate do not show linear changes with age and gestational weeks. With increasing gestational weeks, VitD concentration rapidly increased in women with gestational age < 20 weeks, remained stable between 20 and 30 weeks, and decreased beyond 30 weeks; however, the odds of VitD deficiency showed three different patterns: a rapid decline, a stable period, and a mild increase, respectively. Based on the stratified regression analysis, VitD deficiency odds increased by 16% with each additional week of gestation in pregnant women with gestational age > 30 weeks, OR = 1.16 (1.10–1.22), p < 0.001. Interaction effect analysis indicated that pregnant women over 35 years with gestational weeks between 20 and 30 had the lowest odds of VitD deficiency.ConclusionVitD concentration undergo three phases during pregnancy: rapid increase, plateau, and subsequent decrease. VitD deficiency odds was highest in pregnant women under 25 with gestational ages <20 and lowest in pregnant women over 35 with gestational ages between 20 and 30. The odds of deficiency increase slightly in pregnant women with gestational ages beyond 30 weeks, indicating that they may require additional VitD supplementation.

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Section: Discussionmentioning

confidence: 99%

Three-stage pattern of rapid increase, plateau, and subsequent decline in vitamin D concentration during pregnancy among Chinese women: a large-scale survey

Wang,

Zhang,

et al. 2023

Front. Nutr.

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“…The study also found that earlier intervention during pregnancy can significantly reduce the risk of asthma or recurrent wheezing in offspring, with each week of earlier intervention reducing the odds of the offspring developing asthma and recurrent wheezing by 15%. When compared with daily supplementation of 400 IU of vitamin D, initiating daily intake of 4400 IU of vitamin D between the 9th and 12th weeks can decrease the odds of asthma or recurrent wheezing by a maximum of 55% ( 130 ). Concurrently, a secondary analysis of VDAART by Chen et al.…”

Section: The Clinical Efficacy Of Vitamin D Supplementation In Allerg...mentioning

confidence: 99%

Vitamin D and allergic diseases

Zhang,

Xu,

Zhu

2024

Front. Immunol.

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In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-soluble vitamin, vitamin D plays a crucial role in regulating the immune system and may influence the onset and progression of diseases such as atopic dermatitis, allergic rhinitis, and asthma. To understand the underlying mechanisms, we have summarized the current research on the association between vitamin D and allergic diseases. We also discuss the impact of vitamin D on the immune system and its role in the course of allergic diseases, particularly focusing on how vitamin D supplementation affects the treatment outcomes of these conditions. We aim to provide a theoretical basis and practical guidance for optimizing the management and treatment of allergic diseases by modulating vitamin D levels.

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Association of Vitamin D level and periodontitis: a comprehensive review

Crnić,

Kašaj

2024

Periodontal and Implant Res.

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Periodontitis is a chronic inflammatory disease affecting approximately 40% of the human population, resulting from the immune response to microbial infections in periodontal tissues. While inflammation serves to protect against pathogens, it also leads to tissue damage and is associated with various systemic diseases. Risk factors include diabetes, smoking, and stress, with increasing evidence linking periodontitis to Vitamin D deficiency, which impacts over one billion people worldwide. Vitamin D is essential for maintaining bone health and supporting immune function, and its deficiency has been shown to adversely affect periodontal health. Adequate Vitamin D levels are crucial for effective management of periodontitis, as inflammation can lead to decreased 25(OH)D levels. Recent advancements in point-of-care technology now allows for rapid chairside testing of Vitamin D, significantly enhancing diagnostic efficiency in dental practices. Research indicates that Vitamin D plays a significant role in modulating immune responses, particularly by suppressing pro-inflammatory cytokines. Patients with periodontitis often exhibit lower Vitamin D levels, and supplementation has been shown to improve clinical outcomes, such as clinical attachment level (CAL) and bleeding index (BI). Thus, the use of adjunctive Vitamin D during non-surgical periodontal therapy (NSPT) may enhance treatment effectiveness, although further longitudinal studies are needed to determine optimal dosages and long-term effects. In conclusion, maintaining adequate Vitamin D levels may offer protective benefits against the progression of periodontitis.

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The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing

Cited by 5 publications

References 41 publications

Three-stage pattern of rapid increase, plateau, and subsequent decline in vitamin D concentration during pregnancy among Chinese women: a large-scale survey

Three-stage pattern of rapid increase, plateau, and subsequent decline in vitamin D concentration during pregnancy among Chinese women: a large-scale survey

Vitamin D and allergic diseases

Association of Vitamin D level and periodontitis: a comprehensive review

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