The Impact of Biliopancreatic Diversion with Duodenal Switch (BPD/DS) Over 9 Years

Strain, Gladys; Torghabeh, Mehyar Hefazi; Gautier, Michel; Ebel, Faith; Dakin, Gregory; Abelson, Jonathan S.; Connolly, Daniel J.; Pomp, Alfons

doi:10.1007/s11695-016-2371-1

Cited by 63 publications

(28 citation statements)

References 30 publications

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“…The group of low responders (LWL) was composed of about 20% of patients. Similar results have been obtained in previous studies analyzing clinical outcomes of bariatric surgery (20,22), which makes biliopancreatic diversion with duodenal switch a very successful weight loss therapeutic option with regard to the extent of weight loss and long-term weight loss maintenance (23). The relatively moderate impact of polygenic risk scores on weight loss in the present study could be due to the fact that biliopancreatic diversion with duodenal switch is a very effective surgery, which probably explains why the benefit of adding a polygenic risk score to prediction models, though significant, is not as strong as expected.…”

Section: Discussionsupporting

confidence: 89%

Polygenic risk score for predicting weight loss after bariatric surgery

Toro‐Martín¹,

Guénard²,

Tchernof³

et al. 2018

JCI Insight

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Section: Discussionsupporting

confidence: 89%

Polygenic risk score for predicting weight loss after bariatric surgery

Toro‐Martín¹,

Guénard²,

Tchernof³

et al. 2018

JCI Insight

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“…The observed weight loss after RYGB and BPD/DS in this study was not surprising since several previous studies comparing the two methods in patients with super obesity have found similar results [ 10 , 17 , 18 ], and it has previously been pointed out that weight loss is more sustained after BPD/DS [ 19 ]. In a recent American study by Strain et al [ 20 ], a sustained BMI reduction from 53.4 to 31.5 kg/m 2 was observed throughout the 9 years of observation after BPD/DS. Two previous studies [ 8 , 9 ] observed that more than 50% of the super obese patients still had a BMI >35 kg/m 2 after RYGB.…”

Section: Discussionmentioning

confidence: 94%

Duodenal Switch Is Superior to Gastric Bypass in Patients with Super Obesity when Evaluated with the Bariatric Analysis and Reporting Outcome System (BAROS)

Skogar

Sundbom

2017

OBES SURG

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BackgroundIt is not clear which bariatric procedure that gives the best outcome for patients with super obesity (body mass index [BMI] > 50 kg/m2). This study aims to compare outcomes in patients with super obesity after Roux-en-Y gastric bypass (RYGB) and duodenal switch (BPD/DS) using the Bariatric Analysis and Reporting Outcome System (BAROS) and a local questionnaire for gastrointestinal symptoms.MethodsA retrospective mail survey including 211 patients, 98 RYGB and 113 BPD/DS, with a mean follow-up time of 4 years for both groups. Gender distribution, age, and comorbidities were similar. Weight loss, changes in comorbidities, quality of life (QoL), and adverse events were registered, as well as gastrointestinal symptoms.ResultsPreoperative BMI was higher in the BPD/DS group (56 ± 6.7 vs. 52 ± 4.0 kg/m2, p < 0.01); despite this, the postoperative BMI was lower (31 ± 5.5 vs. 36 ± 7.1 kg/m2, p < 0.01). The effect on diabetes was superior after BPD/DS; otherwise, both groups had a similar reduction in comorbidities. There was no difference in QoL. Adverse events were less common after RYGB (14 vs. 27%). Overall, the BPD/DS group had a superior BAROS score (4.7 ± 2.0 vs. 4.0 ± 2.1, p < 0.05). Dumping was more common after RYGB (p < 0.01), while reflux, diarrhea, fecal incontinence, and problems with malodorous flatus were more common after BPD/DS (all p < 0.05). Frequency of nausea/vomiting and abdominal pain were similar.ConclusionPatients with super obesity have a better weight reduction and metabolic control with BPD/DS, at the cost of higher incidence of adverse events, compared to patients operated with RYGB.

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“…The four most commonly performed bariatric procedures today are sleeve gastrectomy, RYGB, and laparoscopic adjustable banding. [43][44][45][46][47][48][49][50][51][52][53] Laparoscopic sleeve gastrectomy (LSG) is considered primarily a restrictive operation in which 80% of the stomach is removed, resulting in a remaining smaller tubular stomach that holds significantly less volume. 44 In addition to reducing stomach volume, LSG reduces ghrelin production and enhances peptide YY levels, which can significantly affect appetite and increase the procedure's weight loss efficacy.…”

Section: Surgical Weight Loss Therapiesmentioning

confidence: 99%

A Review of Past and Present Weight Loss Strategies and the Potential Role of Bariatric Arterial Embolization

Danda

Bailey

Weiss

2020

Digestive Disease Interventions

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The obesity epidemic is a growing public health concern that has a severe effect on the health care system with significant morbidity, mortality, and cost. Treatment options for obesity include lifestyle modifications, pharmacotherapy, and bariatric surgery. Newer, less-invasive therapies including endoscopic bariatric procedures have been developed in recent years to fill the treatment gap that exists between noninvasive approaches and surgery. Bariatric artery embolization (BAE) is a novel minimally invasive endovascular procedure that has been developed to treat obesity. Recent evidence has suggested that bariatric embolization is well tolerated and can induce clinically significant weight loss through a hormonally mediated mechanism. This article will review existing preclinical and clinical data, and explore future directions of the endovascular treatment of obesity.

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The Impact of Biliopancreatic Diversion with Duodenal Switch (BPD/DS) Over 9 Years

Abstract: Weight loss during the first year was well maintained, resolving comorbidities and improving quality of life. Rates of surgical complications resemble other bariatric procedures. Long-term nutrient deficiencies are of concern.

Cited by 63 publications

References 30 publications

Polygenic risk score for predicting weight loss after bariatric surgery

Polygenic risk score for predicting weight loss after bariatric surgery

Duodenal Switch Is Superior to Gastric Bypass in Patients with Super Obesity when Evaluated with the Bariatric Analysis and Reporting Outcome System (BAROS)

A Review of Past and Present Weight Loss Strategies and the Potential Role of Bariatric Arterial Embolization

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