The impact of binge-like palatable food intake on the endogenous glucagon-like peptide-1 system in female rats

Mukherjee, Ashmita; DiBrog, Adrianne M.; Mietlicki‐Baase, Elizabeth G.

doi:10.1016/j.bbr.2022.113869

Cited by 1 publication

(1 citation statement)

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“…Still, these rats increased plasma GLP1 before food administration, which may indicate an anticipatory food response compared to rats with daily access to the same diet (Mukherjee et al ., 2020; Vahl et al ., 2010; Dailey et al ., 2012). This effect has not been reproduced in female rats (Mukherjee, DiBrog & Mietlicki‐Baase, 2022), suggesting sexual dimorphism in the GLP1 regulation of feeding behaviour. Overall, current evidence suggests that the severity of dysregulated food intake in eating behaviour disorders is associated with a state of GLP1 resistance, supporting the use of GLP1R agonists as a therapeutic tool for these patients (McElroy et al ., 2018).…”

Section: Exploring the Roles Of Leptin Glucocorticoids And Glp1 In Ea...mentioning

confidence: 96%

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

Perez‐Leighton,

Kerr,

Scherer

et al. 2023

Biological Reviews

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Nutritional, endocrine, and neurological signals converge in multiple brain centres to control feeding behaviour and food intake as part of the allostatic regulation of energy balance. Among the several neuroendocrine systems involved, the leptin, glucocorticoid, and glucagon‐like peptide 1 (GLP1) systems have been extensively researched. Leptin is at the top hierarchical level since its complete absence is sufficient to trigger severe hyperphagia. Glucocorticoids are key regulators of the energy balance adaptation to stress and their sustained excess leads to excessive adiposity and metabolic perturbations. GLP1 participates in metabolic adaptation to food intake, regulating insulin secretion and satiety by parallel central and peripheral signalling systems. Herein, we review the brain and peripheral targets of these three hormone systems that integrate to regulate food intake, feeding behaviour, and metabolic homeostasis. We examine the functional relationships between leptin, glucocorticoids, and GLP1 at the central and peripheral levels, including the cross‐regulation of their circulating levels and their cooperative or antagonistic actions at different brain centres. The pathophysiological roles of these neuroendocrine systems in dysregulated intake are explored in the two extremes of body adiposity – obesity and lipodystrophy – and eating behaviour disorders.

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Section: Exploring the Roles Of Leptin Glucocorticoids And Glp1 In Ea...mentioning

confidence: 96%

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

Perez‐Leighton,

Kerr,

Scherer

et al. 2023

Biological Reviews

View full text Add to dashboard Cite

show abstract

The impact of binge-like palatable food intake on the endogenous glucagon-like peptide-1 system in female rats

Cited by 1 publication

References 65 publications

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour

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