2023
DOI: 10.1101/2023.03.05.23286821
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The impact of blinding on trial results: A systematic review and meta-analysis

Abstract: BackgroundBlinding—the concealment of the arm to which participants have been randomized—is an important consideration for assessing risk of bias of randomized trials. A growing body of evidence has, however, yielded inconsistent results on whether trials without blinding produce biased findings.ObjectiveTo conduct a systematic review and meta-analysis of the evidence addressing whether trials with and without blinding produce different results.MethodsWe searched MEDLINE, EMBASE, Cochrane Reviews, JBI EBP, and… Show more

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Cited by 2 publications
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“…If we find evidence that the effects of interventions are different based on their mode (group versus individual, online or in-person), intensity, or dose of delivery, we will create separate nodes. We will group placebo and sham interventions and standard care in the same node (93).…”
Section: Methodsmentioning
confidence: 99%
“…If we find evidence that the effects of interventions are different based on their mode (group versus individual, online or in-person), intensity, or dose of delivery, we will create separate nodes. We will group placebo and sham interventions and standard care in the same node (93).…”
Section: Methodsmentioning
confidence: 99%