The impact of blood and seminal plasma zinc and copper concentrations on spermogram and hormonal changes in infertile Nigerian men

Akinloye, Oluyemi; Abbiyesuku, F M; Oguntibeju, Oluwafemi Omoniyi; Arowojolu, Ayodele O.; Truter, Ernest J

doi:10.1016/s1642-431x(12)60047-3

Cited by 37 publications

(33 citation statements)

References 25 publications

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“…Superoxide, hydroxyl and hydrogen hydroxide radicals are the major ROS present in seminal plasma [46]. Various oxidants can damage cells by starting chemical chain reactions such as lipid peroxidation, or by oxidizing DNA or proteins [47], mutations that are major causes of cancer, and can be reversed by DNA repair mechanism [48]. AZP is one of these oxidants that caused a marked DNA fragmentation of the testicular tissue in rats of the present study.…”

Section: Discussionmentioning

confidence: 53%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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Section: Discussionmentioning

confidence: 53%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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“…Several contradictory studies have examined the correlations between seminal plasma Zn levels and human fertility (Zhao et al, 2016). Some studies showing that Zn concentrations in the seminal plasma of infertile men were significantly lower than those of normal fertile men; however, other studies did not report this finding (Akinloye, Abbiyesuku, Oguntibeju, Arowojolu, & Truter, 2011;Camejo et al, 2011;Jawad, 2013;Turk et al, 2014). Trace elements Fe and Cu are essential for normal physiology of the male genitalia tissues (Tvrda, Peer, Sikka, & Agarwal, 2015).…”

Section: Discussionmentioning

confidence: 99%

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Waheed

Meligy

Dhalam³

2018

Reprod Domestic Animals

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A total of 14 camels of known fertility (controls) at the Camel Research Centre, King Faisal University and 41 infertile dromedaries brought to the Veterinary Teaching Hospital were used in this study during the breeding season. Seminal plasma and serum were obtained from all males, and stored at -80°C until analysis. Concentrations of six trace elements (manganese [Mn], zinc [Zn], iron [Fe], selenium [Se], copper [Cu] and chromium [Cr]) were estimated in the seminal plasma and serum using an atomic absorption spectrophotometer. Results showed significant (p < 0.05 and p < 0.01) differences in semen pH and sperm motility, concentration and abnormalities between the control and infertile dromedaries. In seminal plasma, a significant (p < 0.01) difference in Fe concentrations (7.792 ± 1.567 vs. 61.259 ± 11.967 mg/L) and significant (p < 0.05) differences in Zn (24.763 ± 8.206 vs. 83.981 ± 4.972 mg/L) and Cu (1.653 ± 0.348 vs. 7.905 ± 1.134 mg/L) concentrations existed between the control and infertile dromedaries, respectively. In serum, there were significant (p < 0.05) differences in Fe (6.237 ± 0.695 vs. 151.121 ± 27.604 mg/L) and Cu (24.703 ± 4.195 vs. 6.375 ± 0.644 mg/L) concentrations and a significant (p < 0.01) difference in Zn concentrations (17.086 ± 1.606 vs. 90.422 ± 4.347 mg/L) between the fertile and infertile camels, respectively. There were significant (p < 0.05) positive (r = 0.51) and negative (r = -0.54) correlations between Zn concentrations in seminal plasma and both sperm motility and sperm abnormalities, respectively. In conclusion, seminal plasma and serum trace elements of Fe, Zn and Cu influenced the semen parameters and fertility of dromedary camels. Low concentrations of Fe, Zn and Cu in the seminal plasma were associated with normal fertility in dromedaries.

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“…Zinc concentration in seminal plasma is generally higher than in serum and has been positively correlated with sperm count and motility [21,48,49]. On the other hand, a negative effect of high zinc levels in seminal plasma or in sperm tails on sperm motility has been reported by others [50,51].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation

Talevi

Barbato

Fiorentino

et al. 2013

Reprod Biol Endocrinol

121

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BackgroundSpermatozoa are extremely vulnerable to oxidative stress caused by the unbalance between concentrations of reactive oxygen species and antioxidant scavenging systems present inside the male reproductive tract. In spite of a large number of clinical studies that claimed the beneficial effects of antioxidant oral administration on sperm physiology and fertility, only a few studies were addressed to evaluate their effects on spermatozoa in vitro. Main aims of the present study were to assess the influence of zinc, D-aspartate and coenzyme Q10, included in the dietary supplement Genadis (Merck Serono), on human sperm motility, DNA fragmentation and lipid peroxidation.MethodsSemen samples, obtained from forty-four patients (23–30 years of age) were enrolled in this study, twenty-four were normospermic and twenty patients were oligospermic. Semen samples were analysed for sperm progressive motility and kinetics through computer assisted analysis, DNA fragmentation and lipid peroxidation.ResultsMain results showed that in both normo and oligospermic samples, total and progressive sperm motility is maintained by in vitro treatment with zinc, D-aspartate and coenzyme Q10, whereas a significant decrease of these parameters occurs in parallel samples incubated in medium alone. Zinc, D-aspartate and coenzyme Q10 also prevented the decrease of sperm kinetics but such an effect was highly significant only in oligospermic samples. Moreover, they also protected spermatozoa by the increase of DNA fragmentation and lipid peroxidation.ConclusionsZinc, D-aspartate and coenzyme Q10 exert a direct protective effect on human spermatozoa preventing the decrease of motility and the increase of DNA fragmentation and lipid peroxidation during in vitro culture.

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The impact of blood and seminal plasma zinc and copper concentrations on spermogram and hormonal changes in infertile Nigerian men

Cited by 37 publications

References 25 publications

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation

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