The Impact of Body Resistance Training Exercise on Biomedical Profile at High Altitude: A Randomized Controlled Trial

Abstract

Background. Obesity causes different diseases, eventually. In our study, the results of resistance exercises were examined on selected biochemical markers in Abha City, Saudi Arabia, which is at the height of 2,270 meters above sea level. Methods. A randomized controlled research was conducted with 60 participants equally divided into three groups, 20 subjects in each group: group 1 was composed of obese people who received resistance training exercise, group 2 was composed of the obese control group who did not receive resistance training exercise, and group 3 was composed of normal individuals who received resistance exercise training. The resistance exercises were done in the 6th and 12th weeks. Biochemical blood tests were done. Results. Comparing to the control group, glucose decreased very little with insulin also showing little difference. It has been seen that TC, TG, and LDL reduced to a reasonable extent after resistance exercise, while HDL was increased ( p ≤ 0.01 ). Plasma urea and creatinine showed no differences. Interleukin-6 and leptin decreased significantly ( p ≤ 0.01 ), while there was a significant elevation in adiponectin and testosterone ( p ≤ 0.01 ) once comparing group 1 with group 2 and group 3. Conclusion. We have seen that resistance exercise helps in reducing lipid profile which will result in a decrease of the cardiac and related risk factors when conducted in obese patients in high-altitude regions. Also, alterations of the levels of interleukin-6, leptin, adiponectin, and testosterone showed that resistance exercise is of benefit and favourable in obese persons in high-altitude regions, which can also pave the way for added development of drugs related to the above parameters.

Influence of Training and Single Exercise on Leptin Level and Metabolism in Obese Overweight and Normal-Weight Women of Different Age

“…Trembely et al [58] stated that reduced leptin concentrations persist for a long time after endurance exercises. Similar effects were observed by Zaman et al [59].…”

Exercise and Weight Management: The Role of Leptin—A Systematic Review and Update of Clinical Data from 2000–2022

“…The sedentary overweight men in the Middelbeek, R. J. W. et al [ 77 ] study had reductions in plasma leptin concentrations within 2 weeks of either a HIIT or a progressive-intensity exercise training program. Zaman et al [ 78 ] examined selected biochemical markers in obese adults engaged in 12-week resistance training programs and reported that leptin decreased, while adiponectin increased with exercise.…”

“…When faced with an increase in the metabolic rate, adipocytes secretion of leptin gradually rise and leptin signaling via LR in skeletal muscle induces the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) downstream regulators of cell metabolism, which includes the expression of leptin receptors [ 75 , 76 ]. So, in physiological conditions, an increase in leptin concentrations will induce the expression of LRs and leptin reuptake as a positive feedback that favors the leptin signaling [ 77 , 78 ].…”

“…In general, exercise training programs with a duration between 4 and 12 months, with a standard frequency of 3 to 4 sessions per week, and/or at intensities above 70% of aerobic capability, were effective in reducing basal levels of leptin, especially in individuals with a higher BMI, in which the intensity becomes a determinant factor [ 57 , 71 , 75 , 78 , 81 ]. Individuals with higher rates of leptin secretion exhibit greater changes in response to weight loss.…”

Energy supply and influencing factors of mountain marathon runners from Baiyin marathon accident in China

“…For many years, sports researchers around the world have been conducting similar studies, including pre-competition hypothermia, post-competition hypothermia, and pre-competition and post-competition warming studies 6 at the cold Winter Olympics, as well as various Oxygen inhalation, high-intensity training at high altitudes 7 – 10 , etc., these studies have achieved positive results.…”