The impact of C‐reactive protein‐albumin‐lymphocyte (<scp>CALLY</scp>) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy

Tsunematsu, Masashi; Haruki, Koichiro; Taniai, Tomohiko; Tanji, Yoshiaki; Shirai, Yoshihiro; Furukawa, Kenei; Uwagawa, Tadashi; Onda, Shinji; Yanagaki, Mitsuru; Usuba, Teruyuki; Nakabayashi, Yukio; Okamoto, Tomoyoshi; Ikegami, Toru

doi:10.1002/ags3.12637

Cited by 16 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another investigation study including 1260 colorectal cancer cases reported that CALLY index was independently related to prognosis and had a higher clinical value 14 . Moreover, CALLY index was also significantly related to long-term outcomes in cholangiocarcinoma after surgery, suggesting the significant importance of comprehensive assessment of nutritional status and immune inflammatory response 15 . In addition, with an optimal cut-off value of 3.0, high CALLY index was related to better survival outcomes in those with epithelial ovarian cancer 16 .…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of preoperative CALLY index for prognostication in patients with esophageal squamous cell carcinoma undergoing surgery

Feng,

Wang,

Yang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The C-reactive protein-albumin-lymphocyte (CALLY) index has been identified as a useful and sensitive predictive tool for stratification in cancers. This investigation aimed to validate the prognostic ability of CALLY in esophageal squamous cell carcinoma (ESCC). Clinical characteristics of 318 patients with ESCC who underwent radical excision were gathered and analyzed retrospectively. A restricted cubic spline (RCS) model was used to determine an ideal threshold of CALLY due to the non-linear relation. To investigate the predictors, Cox hazard regression analysis was used. The recursive partitioning analysis (RPA), a method of risk categorization, was also developed for prognostic prediction. The receiver operating characteristic (ROC) curves and decision curve analysis (DCA) curves were used to distinguish from the traditional TNM stage. Patients were compared by groups according to the optimal threshold of CALLY index, which was depicted by the non-linear relation between the cancer-specific survival (CSS) and CALLY index (P < 0.0001). Compared to those with high CALLY index, patients with low CALLY index experienced significantly worse 5-year CSS (21.8% vs. 62.6%, P < 0.001). At different TNM stages, patients with high CALLY index also had better 5-year CSS (I: P = 0.029; II: P < 0.001; III: P < 0.001) in subgroup analyses. The hazard ratio for CSS was 0.368 and CALLY index was an independent predictive factor (P < 0.001). Using TNM stage and CALLY-based RPA algorithms, a new staging was created. The RPA model considerably outperformed the TNM classification for prognostication using ROC (P < 0.001). The DCA also demonstrated that the new model outperformed the TNM stage with significantly improved accuracy for CSS. The prognostic value of CALLY in ESCC undergoing radical resection was initially determined in this study. CALLY was substantially related to prognosis and might be utilized in conjunction with TNM to evaluate ESCC prior to surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical significance of preoperative CALLY index for prognostication in patients with esophageal squamous cell carcinoma undergoing surgery

Feng,

Wang,

Yang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The CALLY index, which is calculated from CRP and Alb re ecting in ammation, and lymphocyte counts re ecting immune function, was reported as an IBPS, and as a postoperative prognostic predictor for hepatocellular carcinoma [11]. The CALLY index is being increasingly reported as being associated with prognosis for various types of carcinomas [11][12][13][14]. In this study, compared to other IBPS, the CALLY index was an accurate prognostic indicator, and a low CALLY index was an independent poor prognostic factor for stage I-III CRC after curative resection.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the C-reactive protein-albumin-lymphocyte (CALLY) index which is calculated from CRP, Alb, and lymphocyte counts drawn from blood examination results, was reported as a new in ammationbased prognostic scores (IBPS) [11]. As it is calculated from in ammatory responses and factors indicative of immune function, it is being increasingly reported as a prognostic indicator for various types of carcinomas [11][12][13][14]. However, a few studies have reported the effect of CALLY index on the prognosis of patients with CRC [15].…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein-albumin-lymphocyte index is a useful indicator for recurrence and survival following curative resection of stage I–III colorectal cancer

Bekki,

Shimomura,

Yano

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose Recently, several simple inflammation-based prognostic scores that can be calculated easily from serum parameters, have been reported to be related to colorectal cancer prognosis. This study aimed to investigate factors influencing the prognosis of patients, including inflammation-based prognostic scores, with stage I–III colorectal cancer following curative resection. Methods This single-center study included 608 patients with stage I–III colorectal cancer who underwent curative resection between April 2010 and December 2018. A retrospective analysis was performed to identify the prognosis-associated variables in these patients. Next, 1659 patients with stage I–III colorectal cancer who underwent curative resection from a multi-center database belonging to the Hiroshima Surgical study group of Clinical Oncology were analyzed for survival. Results Of the inflammation-based prognostic scores, only preoperative C-reactive protein-albumin-lymphocyte index was revealed to predict a poor prognosis in patients with stage I–III colorectal cancer following curative resection. The low C-reactive protein-albumin-lymphocyte index was associated with poor overall survival and recurrence-free survival, which was similar in patients from multi-center database. The C-reactive protein-albumin-lymphocyte index was found to be associated with patient age, systemic condition, comorbidities, and tumor factors. The time-dependent area under the curve for the C-reactive protein-albumin-lymphocyte index was superior to those of other inflammation-based prognostic scores in most postoperative observation periods. Conclusions The preoperative C-reactive protein-albumin-lymphocyte index was independently associated with long-term prognosis in patients with stage I–III colorectal cancer following curative resection.

show abstract

“…In combination, CRP, serum albumin, and lymphocyte levels may be more valuable and reliable biomarkers for predicting outcomes across various diseases, providing both inflammation level, nutritional status, and immune function information ( 33 , 34 ). Tsunematsu et al indicated that the CALLY index can predict long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, highlighting the importance of a comprehensive assessment of inflammatory status ( 67 ). Müller et al ( 68 ) found that the CALLY index was an independent prognostic predictor for overall survival in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE).…”

Section: Discussionmentioning

confidence: 99%

Clinical predictive value of the CRP-albumin-lymphocyte index for prognosis of critically ill patients with sepsis in intensive care unit: a retrospective single-center observational study

Zhang,

Zhao,

Liu

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

BackgroundSepsis is a complex syndrome characterized by physiological, pathological, and biochemical abnormalities caused by infection. Its development is influenced by factors such as inflammation, nutrition, and immune status. Therefore, we combined C-reactive protein (CRP), albumin, and lymphocyte, which could reflect above status, to be the CRP-albumin-lymphocyte (CALLY) index, and investigated its association with clinical prognosis of critically ill patients with sepsis.MethodsThis retrospective observational study enrolled critically ill patients with sepsis who had an initial CRP, albumin, and lymphocyte data on the first day of ICU admission. All data were obtained from the Affiliated Hospital of Jiangsu University. The patients were divided into quartiles (Q1–Q4) based on their CALLY index. The outcomes included 30-/60-day mortality and acute kidney injury (AKI) occurrence. The association between the CALLY index and these clinical outcomes in critically ill patients with sepsis was evaluated using Cox proportional hazards and logistic regression analysis.ResultsA total of 1,123 patients (63.0% male) were included in the study. The 30-day and 60-day mortality rates were found to be 28.1 and 33.4%, respectively, while the incidence of AKI was 45.6%. Kaplan–Meier analysis revealed a significant association between higher CALLY index and lower risk of 30-day and 60-day mortality (log-rank p < 0.001). Multivariate Cox proportional hazards analysis indicated that the CALLY index was independently associated with 30-day mortality [HR (95%CI): 0.965 (0.935–0.997); p = 0.030] and 60-day mortality [HR (95%CI): 0.969 (0.941–0.997); p = 0.032]. Additionally, the multivariate logistic regression model showed that the CALLY index served as an independent risk predictor for AKI occurrence [OR (95%CI): 0.982 (0.962–0.998); p = 0.033].ConclusionThe findings of this study indicated a significant association between the CALLY index and both 30-day and 60-day mortality, as well as the occurrence of AKI, in critically ill patients with sepsis. These findings suggested that the CALLY index may be a valuable tool in identifying sepsis patients who were at high risk for unfavorable outcomes.

show abstract

The impact of C‐reactive protein‐albumin‐lymphocyte (CALLY) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy

Cited by 16 publications

References 22 publications

Clinical significance of preoperative CALLY index for prognostication in patients with esophageal squamous cell carcinoma undergoing surgery

Clinical significance of preoperative CALLY index for prognostication in patients with esophageal squamous cell carcinoma undergoing surgery

C-reactive protein-albumin-lymphocyte index is a useful indicator for recurrence and survival following curative resection of stage I–III colorectal cancer

Clinical predictive value of the CRP-albumin-lymphocyte index for prognosis of critically ill patients with sepsis in intensive care unit: a retrospective single-center observational study

Contact Info

Product

Resources

About