The impact of cadmium on male infertility

Skolarczyk, Justyna; Pekar, Joanna; Skórzyńska-Dziduszko, Katarzyna; Małecka‐Massalska, Teresa; Budzynski, M.

doi:10.5601/jelem.2017.22.2.1320

Cited by 5 publications

(4 citation statements)

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“…Additionally, sperm count is one of the most important factors to look at when evaluating spermatogenesis and fertility (Kumar et al, 2021;Omu, 2019). Cadmium can also affect how well the testicles' function (Skolarczyk et al, 2018). The results of this study also indicated that cadmium treatment decreased the number, motility, and percentage of live sperm in rats, which is consistent with previous research showing that cadmium inhibits testicular function (López-Botella et al, 2021;Zhao et al, 2017;Zhu et al, 2020;Ali et al, 2022).…”

Section: Groups/parameterssupporting

confidence: 92%

Assessment of Testicular Recovery of Ethanolic Extracts of Calocybe Indica Following Cadmium Chloride-Induced Testicular Toxicity in Rats

Akor,

Chude

et al. 2024

AFJPS

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Occupational and environmental exposure to cadmium poses a harmful consequence inherent to its toxicity. In addition to harming target cells to varied degrees, it primarily affects the liver, kidney, and testes. It may be found in food, the atmosphere, and possibly even drinking water. In this study, the effect of the mushroom Calocybe indica (CLE) on rats' testicular toxicity caused by cadmium chloride (CdCl 2 ) is being evaluated. The six groups of experimental animals, each with five animals, were utilized. Groups B, C, D, E, and F received subcutaneous injections of (3 mg/kg CdCl 2 ), while Group A served as the experiment's control group. For 21 days, group C received an oral dose of 100 mg/kg of vitamin C. For 21 days, Groups D, E, and F received CLE treatments at doses of 200 mg/kg, 400 mg/kg, and 800 mg/kg respectively. It was evident that exposure to 3 mg/kg of cadmium chloride for three weeks resulted in substantial harm to the reproductive system. In this study, it has been established that administering the mushroom extract (Calocybe indica) to the rats induced with cadmium chloride testicular toxicity for three weeks resulted in to increase in antioxidant activity as well as a minor reduction in the toxicity of cadmium to the testicles.

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Section: Groups/parameterssupporting

confidence: 92%

Assessment of Testicular Recovery of Ethanolic Extracts of Calocybe Indica Following Cadmium Chloride-Induced Testicular Toxicity in Rats

Akor,

Chude

et al. 2024

AFJPS

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“…Cadmium may also alter Leydig cells hormones by affecting the hypothalamus–pituitary–testis axis (Siu et al, ). Cadmium affects spermatogenesis by disrupting Leydig cells and testosterone secretion (Skolarczyk, Budzyński, Pekar, Małecka‐Massalska, & Skórzyńska‐Dziduszko, ). Therefore, reduction in sperm density in the lumen of seminiferous tubules in the cadmium chloride group could be attributed to cadmium effects on reducing testosterone levels.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of silymarin on testis histopathology, oxidative stress indicators, antioxidant defence enzymes and serum testosterone in cadmium‐treated mice

2019

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Cadmium is known as an oxidative stress‐inducing factor. Silymarin extracted from Silybum marianum is regarded as a potent antioxidant. The present study investigated the preventing effects of silymarin on cadmium chloride‐induced toxicity in terms of testis histopathology and serum testosterone level as well as oxidative stress indicators in mice. In addition, the activities of antioxidant defence enzymes was evaluated. Adult male mice were divided into four groups (n = 6 in each group): (a) control; (b) cadmium chloride; (c) silymarin + cadmium chloride and (d) Silymarin. In this study, cadmium chloride significantly decreased the diameter and wall thickness of the seminiferous tubule, diameter of the spermatogonia nucleus and serum testosterone levels compared to the control group. Furthermore, in mice treated with this pollutant, a significant increase in malondialdehyde was observed while ferric reducing antioxidant power level, and the activity of catalase, superoxide dismutase and glutathione peroxidase were significantly reduced in the testis. In the silymarin + cadmium chloride group, silymarin could significantly reverse the toxic effects of cadmium chloride. The findings of this study showed that silymarin, as a potent antioxidant, can compensate the adverse effects of cadmium chloride on testis histopathology, testosterone level, oxidative stress indicators and antioxidant defence enzymes in mice.

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“…they also have found that sperm count, motility, and semen volume were signi cantly lower in infertile men (28). So many other studies suggested the relationship between higher serum levels of lead and cadmium and attenuated sperm quality (29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 92%

Association Between Meat Intake and Semen Parameters Among Iranian Infertile Men: A Cross-sectional Study

Ghiasvand

Haeri

ShariatPanahi

et al. 2020

Preprint

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Objective: Previous studies have proven the effect of dietary patterns on semen quality indicators, but research on the relationship between meat intake and semen quality is limited. Therefore, this study was conducted to investigate the relationship between Meat intake with semen quality.Methods: In this cross sectional study, 400 infertile men were recruited into study during their fertility investigation in Yazd Reproductive Sciences Institute Diagnosed by an andrologist according to the inclusion criteria. Multivariate logistic regression was used to determine the relationship between meat intake and semen parameters. All data were analyzed using SPSS V. 22 software.Results: We found that intake of canned tuna can have two different effects on sperm motility in infertile male. Intake of canned tuna according to the serving size stated in quartile 2, leads to a decrease in the percentage of immotile sperm from 52.93 (CI95%, 51.15-54.71) to 46.55 (CI95%, 44.56-48.54)(Ptrend=0.036). On the other hand, there is an increase in the percentage of immotile sperm from 46.55 (CI95%, 44.56-48.54) to 52.88 (CI95%, 50.94-54.82) in the highest quartile of canned tuna intake.Also, no significant relationship was observed between intake other types of meats and sperm quality indices.Conclusions: We found that intake of canned tuna,base on serving size of quartile 2, is associated with lower percentage of immotile sperm, on the other hand high intake of canned tuna increase percentage of immotile sperm in Iranian infertile men. More extensive studies are recommended in this regard.

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The impact of cadmium on male infertility

Cited by 5 publications

References 0 publications

Assessment of Testicular Recovery of Ethanolic Extracts of Calocybe Indica Following Cadmium Chloride-Induced Testicular Toxicity in Rats

Assessment of Testicular Recovery of Ethanolic Extracts of Calocybe Indica Following Cadmium Chloride-Induced Testicular Toxicity in Rats

Protective effects of silymarin on testis histopathology, oxidative stress indicators, antioxidant defence enzymes and serum testosterone in cadmium‐treated mice

Association Between Meat Intake and Semen Parameters Among Iranian Infertile Men: A Cross-sectional Study

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