The Impact Of Cannabinoids On Breast Cancer Cell Lines: A Meta-Analysis And Systematic Review Of Antitumoral Effects

Abstract

Breast cancer remains a major global health concern with limited treatment options. Metastasis and resistance to conventional therapies contribute to the poor prognosis associated with this disease. In recent years, interest has grown in exploring the potential of photochemical, such as cannabidiol and Δ9-tetrahydrocannabinol derived from Cannabis sativa, as alternative anticancer agents. This systematic review and meta-analysis aim to investigate the ant proliferative effects of cannabidiol on breast cancer cell lines, particularly triple-negative and receptor-positive cells. A comprehensive search of electronic databases was conducted to identify relevant studies published in English and Spanish. Eligible studies were assessed for quality using the Cell Culture Study Quality Evaluation Guide (CCSQEG) and data extraction was performed. Nineteen studies were included in the qualitative synthesis, and ten studies were thoroughly analyzed for quantitative assessments. The results demonstrated that cannabidiol exhibited significant ant proliferative effects on breast cancer cells, irrespective of receptor status. The weighted average of the logarithms of odds ratios revealed a strong association between cannabidiol administration and inhibition of tumour growth in breast cancer cells (OR = 0.531, 95% CI: 0.429-0.656, p < 0.001). These findings suggest that cannabidiol has the potential to be a therapeutic agent for breast cancer. However, more comprehensive studies are required to elucidate the underlying mechanisms and optimize treatment strategies involving CBD in breast cancer.