The Impact of Caregiver Depression on Child Asthma Outcomes: Pathways and Mechanisms

Brown, E. Sherwood; Palka, Jayme M.; Lehman, Heather K.; Kulikova, Alexandra; Khan, David A.; Lopez, J.; Antony, Anna; Persaud, Donna; Tiro, Jasmine; Ivleva, Elena I.; Nakamura, Alyson; Patel, Zena; Holmes, Traci; Humayun, Quratulain; Lloyd, Tressa; Allen, Karen; Kaur, Savitoj; Owitz, M. Seth; Pak, Ray J.; Zablonski, Kevin G.; Adragna, Michael S.; Chankalal, Raymond; Wood, Beatrice L.; Miller, Bruce D.

doi:10.1016/j.jaip.2022.09.016

Cited by 7 publications

(2 citation statements)

References 47 publications

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“… 37 Notably, a recent study found that caregiver depression remission improved childhood asthma outcomes, which was partially mediated by improvements in the severity of children’s depressive symptoms. 38 …”

Section: Discussionmentioning

confidence: 99%

Childhood Asthma and Parental Antidepressant Use in a Nationwide Danish Cohort

Guerrero¹,

Håkansson²,

Backer³

et al. 2023

JAA

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Background: Paediatric asthma is associated with caregiver depression, which in turn is associated with poor asthma control. Although sociodemographic risk factors are associated with parental depression among children with asthma, the contribution of these factors to caregiver depression in free-to-access universal healthcare settings is unknown. Methods: The association between childhood asthma and parental antidepressant use was investigated in a Danish nationwide cohort of children aged 2-17 years that redeemed inhaled corticosteroids in 2015. The odds of antidepressant use were estimated in comparison to control families that were matched 1:1 on the number of siblings, residence, income, and education. Results: Among the families of 28,595 children with actively treated asthma, 12% of mothers and 6.2% of fathers were on antidepressant therapy, compared to 9.3% and 5.3% in controls (p<0.001). Paediatric asthma was associated with increased odds of parental antidepressant use )), even after adjusting for parental asthma. Poor asthma control, but not higher asthma severity, was associated with higher odds of antidepressant use (1.43 (1.31-1.56)). Compared with the controls, families with two or more children with asthma had higher )) than those with a single child ). Low socioeconomic status was associated with parental antidepressant use. Conclusion:Caregiver depression in a Danish cohort is more prevalent among mothers than among fathers and is associated with poor asthma control in children. Antidepressant use among caregivers was associated with total family asthma burden and was independent of socioeconomic status.

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Section: Discussionmentioning

confidence: 99%

Childhood Asthma and Parental Antidepressant Use in a Nationwide Danish Cohort

Guerrero¹,

Håkansson²,

Backer³

et al. 2023

JAA

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“…Brown et al. suggested that a reduction in melancholy among family caregivers could effectively control the onset and progression of depression in children with asthma ( 112 ). By contrast, conventional drug therapy, which includes cortisol hormones, β-adrenergic agonists, etc., may have varying effects on the nervous system because of their specific modes, doses, frequencies, etc., and their benefits and drawbacks contradict the conclusions of the current study.…”

Section: Treatment Of Symptoms Associated With Brain Response In Asthmamentioning

confidence: 99%

Brain response in asthma: the role of “lung-brain” axis mediated by neuroimmune crosstalk

Wang,

Mou,

Wang

et al. 2023

Front. Immunol.

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In addition to typical respiratory symptoms, patients with asthma are frequently accompanied by cognitive decline, mood disorders (anxiety and depression), sleep disorders, olfactory disorders, and other brain response manifestations, all of which worsen asthma symptoms, form a vicious cycle, and exacerbate the burden on families and society. Therefore, studying the mechanism of neurological symptoms in patients with asthma is necessary to identify the appropriate preventative and therapeutic measures. In order to provide a comprehensive reference for related research, we compiled the pertinent literature, systematically summarized the latest research progress of asthma and its brain response, and attempted to reveal the possible “lung–brain” crosstalk mechanism and treatment methods at the onset of asthma, which will promote more related research to provide asthmatic patients with neurological symptoms new hope.

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