The impact of cellular elements of TME on melanoma biology and its sensitivity to EGFR and MET targeted therapy

Wądzyńska, Justyna; Simiczyjew, Aleksandra; Pietraszek-Gremplewicz, Katarzyna; Kot, Magdalena; Ziętek, Marcin; Matkowski, Rafał; Nowak, Dorota

doi:10.1016/j.bbamcr.2023.119549

Cited by 1 publication

(1 citation statement)

References 71 publications

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“…Additionally, an elevation in perilipin 2 levels was observed in melanoma cells that were cocultured with adipocytes. To confirm the impact of adipocytes on lipid accumulation in melanoma cells, lipid droplet staining was conducted, which showed increased lipid levels in metastatic melanoma cells after coculturing with adipocytes [ 97 ]. Moreover, a rise in lipid content was recorded in metastatic melanoma cells after coculture with cancer-associated adipocytes [ 97 ], corroborating the findings by Kwan et al, who noted higher levels of fatty acids, particularly palmitoleic acid, in melanoma cells incubated with adipocytes [ 98 ].…”

Section: Lipid Metabolic Dynamics In the Melanoma Microenvironmentmentioning

confidence: 99%

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Kook,

Kim

2024

Metabolites

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Lipids, as multifunctional molecules, play a crucial role in a variety of cellular processes. These include regulating membrane glycoprotein functions, controlling membrane trafficking, influencing apoptotic pathways, and affecting drug transport. In addition, lipid metabolites can alter the surrounding microenvironment in ways that might encourage tumor progression. The reprogramming of lipid metabolism is pivotal in promoting tumorigenesis and cancer progression, with tumors often displaying significant changes in lipid profiles. This review concentrates on the essential factors that drive lipid metabolic reprogramming, which contributes to the advancement and drug resistance in melanoma. Moreover, we discuss recent advances and current therapeutic strategies that employ small-molecule inhibitors to target lipid metabolism in skin cancers, particularly those associated with inflammation and melanoma.

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Section: Lipid Metabolic Dynamics In the Melanoma Microenvironmentmentioning

confidence: 99%

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Kook,

Kim

2024

Metabolites

View full text Add to dashboard Cite

show abstract

The impact of cellular elements of TME on melanoma biology and its sensitivity to EGFR and MET targeted therapy

Cited by 1 publication

References 71 publications

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer

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