The impact of change in physical activity on change in arterial stiffness in overweight or obese sedentary young adults

Hawkins, Marquis; Gabriel, Kelley Pettee; Cooper, Jennifer N.; Storti, Kristi L.; Sutton-Tyrrell, Kim; Kriska, Andrea M.

doi:10.1177/1358863x14536630

Cited by 28 publications

(26 citation statements)

References 49 publications

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“…A study in a middle‐aged, overweight, and diabetic subsample of the Framingham Heart Study third‐generation cohort observed a significant effect of 0.53 m/s lower PWV with every 10min MVPA per day, 31 which is comparable to our results. Another study in healthy middle‐aged individuals with obesity demonstrated a 0.05‐0.38 m/s reduction of baPWV per 8 min/d increase of MVPA in a 12 months intervention 32 . They also observed a reduction of c‐reactive protein as well as improved insulin sensitivity, blood lipid profile, and mean arterial blood pressure.…”

Section: Discussionmentioning

confidence: 90%

Physical activity is favorably associated with arterial stiffness in patients with obesity and elevated metabolic risk

et al. 2020

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Objectives Physical activity and cardiorespiratory fitness (CRF) are relevant modifiers of cardiovascular risk. Their independent effects on arterial stiffness have not been assessed in people with obesity. This study aimed to assess the independent effects of light (LPA) and moderate‐to‐vigorous (MVPA) physical activity and CRF on Pulse wave velocity (PWV). Methods Brachial‐ankle PWV (baPWV) was measured cross‐sectionally in 55 subjects (43.0 ± 13.8 years; 66% women) with moderate cardiovascular risk. Body composition was assessed with bioelectrical impedance‐analysis. Daily minutes of LPA and MVPA were measured by accelerometry and CRF (peak oxygen uptake [VO2peak]) with spiroergometry. Independent effects of LPA, MVPA, and VO2peak on baPWV were analyzed in an age‐, sex‐, body fat mass‐, and blood pressure‐adjusted ANOVA. Results Every 10 minutes increase of daily MVPA was associated with a 2.8% (0.32m/s [−0.64 to 0.001 m/s], P = .05) reduction of baPWV, whereas LPA and VO2peak had only a little or no relevant effects on baPWV. Conclusions Higher MVPA is associated with lower composite arterial stiffness independent of CRF and the number of metabolic risk factors in patients with obesity and further metabolic risk factors. Thus, lifestyle interventions should aim for an increase in MVPA. BaPWV may improve the monitoring of favorable effects of MVPA, even if an improvement of VO2 peak cannot be obtained.

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Section: Discussionmentioning

confidence: 90%

Physical activity is favorably associated with arterial stiffness in patients with obesity and elevated metabolic risk

et al. 2020

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“…In a medium sized longitudinal study particularly PA at higher intensity was favorable regarding central and peripheral arterial stiffness in younger persons [14,15]. In the only study analyzing baPWV and PA intensities an increase in moderate-to-vigorous PA, but not light intensity PA, was linked with a decrease of baPWV in 274 overweight and obese young adults longitudinally within one year [20]. In 103 postmenopausal women moderate and vigorous PA was inversely associated with central arterial stiffness [19].…”

Section: Discussionmentioning

confidence: 99%

“…CAVI reflects arterial stiffness of the aorta and the iliac, femoral and tibial arteries [25] and baPWV between the brachial and tibial arteries [29]. Since both of these indices cover different segments of the arterial tree, they reflect a combination of central and peripheral arterial stiffness [20,21].…”

Section: Arterial Stiffness Measurementmentioning

confidence: 99%

“…The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) are mixed measures of central and peripheral arterial stiffness that have mainly been studied in Asian populations so far [20,21]. There are no data on the population level in older adults of the association between different intensities of PA and arterial stiffness measured by CAVI and baPWV.…”

Section: Introductionmentioning

confidence: 99%

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Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study

et al. 2015

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Associations of physical activity (PA) intensity with arterial stiffness in older adults at the population level are insufficiently studied. We examined cross-sectional associations of self-reported PA intensities with arterial stiffness in elderly Caucasians of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults. Mixed central and peripheral arterial stiffness was measured oscillometrically by the cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV). The self-reported International Physical Activity Questionnaire long version was administered to classify each subject's PA level. We used univariable and multivariable mixed linear and logistic regression models for analyses in 1908 persons aged 50 years and older. After adjustment for several confounders moderate, vigorous and total PA were inversely associated with CAVI (p = 0.02-0.03). BaPWV showed negative and marginally significant associations with vigorous and moderate PA (each p = 0.06), but not with total PA (p = 0.28). Increased arterial stiffness (CAVI 9, upper tertile) was inversely and significantly associated with vigorous PA [odds ratio (OR) 0.65, 95 % confidence interval (CI) 0.48-0.88], and marginally significantly with total PA (OR 0.76, 95 % CI 0.57-1.02) and moderate PA (OR 0.75, 95 % CI 0.56-1.01). The odds ratio for baPWV 14.4 was 0.67 (95 % CI 0.48-0.93) across the vigorous PA levels, and was non-significant across the total (OR 0.91, 95 % CI 0.66-1.23) and moderate PA levels (OR 0.94, 95 % CI 0.69-1.28). In this general Caucasian population of older adults higher levels especially of vigorous PA were associated with lower arterial stiffness. These data support the importance of PA for improving cardiovascular health in elderly people.

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“…For instance, in overweight-to-obese adults, a modest increase in physical activity was associated with reduced arterial stiffness, a risk factor of future cardiovascular events [13]. Furthermore, in patients with a diagnosed cardiovascular disease, an inverse association between physical activity and mortality was shown (i.e.…”

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confidence: 99%

Understanding the impact of physical activity in COPD outcomes: moving forward

ZuWallack

Esteban

2014

Eur Respir J

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@ERSpublications From observational studies, it is now clear that physical inactivity is linked with poor outcome in COPD http://ow.ly/AJ7mFArguably, three outcome categories are of greatest importance to chronic obstructive pulmonary disease (COPD) patients, their families and their caregivers: health-related quality of life (including symptom burden); hospitalisations and other forms of healthcare utilisation; and, of course, mortality. Lower levels of baseline physical activity are not only prevalent in patients with COPD [1, 2], they are associated a negative impact in each of these three outcome categories [3][4][5].Of considerable importance to healthcare professionals, increases in physical activity appear to predict enhanced health-related quality of life and reduced hospitalisations. For example, in an analysis of 391 patients with COPD who had physical activity and health-related quality of life assessments at baseline and 5 years later [6], those who increased or maintained their high levels of physical activity had clinically meaningful improvements in quality of life. In contrast, those who stayed at a low level or decreased their physical activity had a worsening in this outcome. From one perspective, this comes close to a tautology, as physical function impairment and distressing symptoms associated with physical activity are prominent components of health-related quality of life questionnaires. With respect to healthcare utilisation, a longitudinal analysis of COPD patients over 5 years demonstrated that the change in physical activity over the first 2 years significantly predicted hospitalisations 3 years later: those without regular physical activity, those who maintained a low level of physical activity or those who decreased their physical activity were at significantly greater risk of being hospitalised than those with higher levels of physical activity [7].The reanalysis of the very large Copenhagen City Heart Study database by VAES et al. [8], reported in this issue of the European Respiratory Journal, adds new and important information by relating changes in physical activity to mortality risk in COPD. We already know there are often strong associations between low levels of physical and mortality. For instance, all-cause mortality risk is higher in patients with coronary artery disease and cancer who have lower levels of physical activity [9,10]. This also holds true for COPD: using Copenhagen City Heart Study data, demonstrated that, in participants meeting spirometric criteria for COPD, those with very low levels of self-reported physical activity had a higher risk of hospitalisation and mortality over approximately the next 17 years than those who participated in regular physical activity. This negative relationship between physical activity and poor outcome remained in their model even after controlling for potential relevant confounding factors. This study provides strong evidence that physical inactivity is bad for individuals with COPD. Subsequent studies by WASCHKI et al. [4] a...

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The impact of change in physical activity on change in arterial stiffness in overweight or obese sedentary young adults

Cited by 28 publications

References 49 publications

Physical activity is favorably associated with arterial stiffness in patients with obesity and elevated metabolic risk

Physical activity is favorably associated with arterial stiffness in patients with obesity and elevated metabolic risk

Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 Cohort Study

Understanding the impact of physical activity in COPD outcomes: moving forward

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