The impact of changing smoking habits and smoke-free legislation on orofacial cleft incidence in the United Kingdom: evidence from two time-series studies
Abstract:Objectives: To analyse the association between active and passive cigarette
smoking and the incidence of children born with a cleft lip and/or palate within the United Kingdom.
Design: First, a longitudinal time-series study was conducted with routinely
collected smoking prevalence data for females over 16 years of age. Second, an interrupted time-series design was used as a natural experiment to assess the impact of smoke-free legislation using segmented Poisson regression.
Setting: United Kingdom.
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