The impact of childhood maltreatment on biological systems: Implications for clinical interventions

doi:10.1093/pch/18.8.415

Cited by 25 publications

(15 citation statements)

References 43 publications

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“…23 From a biological perspective, it has been theorized that exposure to adverse experiences may result in a variety of physiological changes during childhood including increased activation of neurobiological systems such as the hypothalamic-pituitary-adrenal (HPA) axis or the sympathetic nervous system, thereby increasing the vulnerability to stress in later life. [24][25][26] At the same time, findings from psychoneuroimmunological research indicate that stress may alter inflammatory responses and contribute the development of atopic disease. 27 When interpreting our finding that CM history is not related to AD in adults, the following aspects should be considered.…”

Section: Discussionmentioning

confidence: 99%

Childhood maltreatment is not associated with atopic dermatitis in adults: results from a cross‐sectional population‐based cohort study

Piontek¹,

Ittermann

Wiesmann

et al. 2022

Acad Dermatol Venereol

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Background Childhood maltreatment (CM) is related to poor physical and mental health outcomes in adults. Knowledge on the impact of CM on skin diseases is limited, and no study has previously addressed the association of CM with atopic dermatitis (AD) in adult age.Objectives To analyse the prevalence of CM in individuals with physician-diagnosed AD, and to examine the relationship between different types of CM with physician-diagnosed AD in a general population sample of German adults.Methods Data from 2973 participants from the cross-sectional population-based Study of Health in Pomerania (SHIP) TREND-0 were analysed (aged 20 to 83 years; 51.4% female). We administered the Childhood Trauma Questionnaire (CTQ) assessing emotional, physical and sexual abuse, and emotional and physical neglect. AD was diagnosed by dermatologists in a standardized clinical examination. We conducted logistic regression analyses adjusted for age, sex and school education to investigate the association of CM types with AD.Results Among all individuals with AD, 20.6% reported to have experienced at least one type of moderate or severe CM. Emotional and physical neglect were the most frequently reported CM types. Overall, the prevalence of CM types among individuals with AD did not differ from those among individuals without AD. We found no association of CM type with AD.Conclusions This is the first study investigating the association of CM with AD in adults. CM was common in the present general population sample, emphasizing that CM is an important public health problem. Our findings suggest that CM is not a risk factor for AD. It might be hypothesized that AD severity is a crucial outcome, and that CM history is a factor with impact on disease severity and course rather than a risk factor for the development of AD. Longitudinal studies are required to address this question.

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Section: Discussionmentioning

confidence: 99%

Childhood maltreatment is not associated with atopic dermatitis in adults: results from a cross‐sectional population‐based cohort study

Piontek¹,

Ittermann

Wiesmann

et al. 2022

Acad Dermatol Venereol

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“…Childhood maltreatment (due to prolonged stress) is associated with dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, which plays a major role in immune system functioning. Disruption in immune system markers [pro-and anti-inflammatory substances (e.g., C-reactive protein, interleukin-6, adiponectin, or cell-mediated immunity)] contributes to increased risk of infections, as well as the development of autoimmune disorders or other chronic disorders, including those associated with pain (85).…”

Section: Discussionmentioning

confidence: 99%

Childhood Trauma, Emotion Regulation, and Pain in Individuals With Alcohol Use Disorder

et al. 2020

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Introduction: Several studies have confirmed that the experience of childhood trauma, poor emotion regulation, as well as the experience of physical pain may contribute to the development and poor treatment outcomes of alcohol use disorder (AUD). However, little is known about how the joint impact of these experiences may contribute to AUD. Objectives:To analyze associations between childhood trauma, emotion regulation, and pain in individuals with AUD. Methods:The study sample included 165 individuals diagnosed with AUD. The Childhood Trauma Questionnaire (CTQ) was used to investigate different types of trauma during childhood (physical, emotional, and sexual abuse and neglect), the Brief Symptom Inventory was used to assess anxiety symptoms, the Difficulties in Emotion Regulation Scale (DERS) was used to assess emotional dysregulation, and the Pain Resilience Scale and Pain Sensitivity Questionnaire were used to measure self-reported pain tolerance and sensitivity.Results: Childhood emotional abuse (CTQ subscale score) was positively associated with anxiety, anxiety was positively associated with emotional dysregulation, and emotional dysregulation was negatively associated with pain tolerance. Accordingly, there was support for a significant indirect negative association between childhood emotional abuse and pain tolerance. The serial mediation statistical procedure demonstrated that anxiety and emotional dysregulation mediated the effect of childhood emotional abuse on pain resilience among individuals with AUD.Conclusions: Targeting emotional dysregulation and physical pain that can result from childhood trauma may have particular therapeutic utility among individuals treated for AUD.

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“…Childhood maltreatment (CM) includes sexual, physical, emotional abuse, and physical and emotional neglect and is considered a repetitive and chronic stressor rather than a single event ( Madigan et al, 2019 ). CM can impair the psychological and biological development of affected individuals and also their later functioning in adolescence and adulthood, especially when it occurs early in life ( Jaffee and Maikovich-Fong, 2011 ; Alink et al, 2012 ; Norman et al, 2012 ; Gonzalez, 2013 ; Madigan et al, 2015 ). The negative consequences of CM on physical and mental health are robustly documented in the literature (for a meta-analysis see, Humphreys et al, 2020 ), with additional evidence for transmission of adversity and health consequences also to the next generation ( Norman et al, 2012 ; Leve et al, 2015 ; Narayan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

Buchheim

Ziegenhain

Kindler

et al. 2022

Front. Hum. Neurosci.

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IntroductionChildhood maltreatment (CM) is a developmental risk factor and can negatively influence later psychological functioning, health, and development in the next generation. A comprehensive understanding of the biopsychosocial underpinnings of CM transmission would allow to identify protective factors that could disrupt the intergenerational CM risk cycle. This study examined the consequences of maternal CM and the effects of psychosocial and biological resilience factors on child attachment and stress-regulatory development using a prospective trans-disciplinary approach.MethodsMother-child dyads (N = 158) participated shortly after parturition (t0), after 3 months (t1), and 12 months later (t2). Mothers’ CM experiences were assessed at t0, attachment representation at t1 and psychosocial risk and social support were assessed at t1 and t2. At t2, dyads participated in the Strange Situation Procedure (SSP). Children’s attachmen status were classified as organized vs. disorganized, including their level of disorganized behavior, and heart rate (HR) and respiratory sinus arrhythmia (RSA) were recorded as stress response measures of the autonomic nervous system. Maternal caregiving during SSP was assessed using the AMBIANCE scale. Child’s single nucleotide polymorphisms rs2254298 within the oxytocin receptor (OXTR) and rs2740210 of the oxytocin gene (OXT) were genotyped using DNA isolated from cord blood.ResultsMaternal CM experiences (CM+) were significantly associated with an unresolved attachment status, higher perceived stress and more psychological symptoms. These negative effects of CM were attenuated by social support. As expected, maternal unresolved attachment and child disorganized attachment were significantly associated. Maternal caregiving did not mediate the relationship between maternal and child attachment but influenced children’s HR and RSA response and disorganized behavior. Moreover, the rs2254298 genotype of the OXTR gene moderated the stress response of children from mothers with CM. Children carrying the rs2740210 risk allele of the OXT gene showed more disorganized behavior independent from maternal CM experiences.ConclusionWe replicated and extended existing CM and attachment models by co-examining maternal attachment, social support, and child genetic susceptibility on child attachment and cardiovascular stress regulation. The findings contribute to an extended understanding of risk and resilience factors and enable professionals to target adequate services to parents and children at risk.

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The impact of childhood maltreatment on biological systems: Implications for clinical interventions

Cited by 25 publications

References 43 publications

Childhood maltreatment is not associated with atopic dermatitis in adults: results from a cross‐sectional population‐based cohort study

Childhood maltreatment is not associated with atopic dermatitis in adults: results from a cross‐sectional population‐based cohort study

Childhood Trauma, Emotion Regulation, and Pain in Individuals With Alcohol Use Disorder

Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

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