The impact of childhood parental loss on risk for depression and anxiety in adulthood: A community-based study in Southwest China

Peng, Anjiao; Qiu, Xiangmiao; Ji, Song; Huang, Dan; Dong, Baijun; Song, Tingting; Huang, Cheng; Chen, Lei

doi:10.1016/j.jad.2021.10.093

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…The scores were categorised into the absence of depression (0–4), mild depression (5–9), moderate depression (10–14) and severe depression (15–27). 14 Polypharmacy means the use of multiple drugs administered to the same patient. Published papers have used disparate cut-offs for polypharmacy, ranging from 2 to 9 medications.…”

Section: Methodsmentioning

confidence: 99%

“…Depressive symptoms were assessed using the Brazilian validated version of the Patient Health Questionnaire 9-item instrument. The scores were categorised into the absence of depression (0–4), mild depression (5–9), moderate depression (10–14) and severe depression (15–27) 14. Polypharmacy means the use of multiple drugs administered to the same patient.…”

Section: Methodsmentioning

confidence: 99%

“…(5-9), moderate depression (10)(11)(12)(13)(14) and severe depression (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). 14 Polypharmacy means the use of multiple drugs administered to the same patient. Published papers have used disparate cut-offs for polypharmacy, ranging from 2 to 9 medications.…”

Section: Open Accessmentioning

confidence: 99%

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Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China

et al. 2022

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ObjectiveThis study aims to investigate the prevalence and risk factors of falls among the elderly in Guangdong, China.MethodsA cross-sectional study was conducted in six communities of Guangdong province. People over 60 years old were selected with multistage random-cluster sampling. Data on falls within the previous 12 months and fall-related risk factors were collected through a face-to-face interview.ResultsThe prevalence of falls among older adults was 11.9% (95% CI: 11.0% to 12.8%) among 5374 interviewees. The common injuries caused by falls were bruises/scrapes (40.0%) and fractures (15.5%), and most people fall while doing housework (35.0%). Univariate analysis showed that 14 factors were associated with falls among older adults, including gender, age, residence, occupation, education level, balance ability, situation of cognition, disease, depression, living arrangement, marital status, the behaviour of exercise, drinking and drug use (p<0.05). Multivariate analysis showed that the associated factors of falls among older adults included woman (OR=1.68, 95% CI: 1.40 to 2.02), age from 70 to 79 years (OR=1.31, 95% CI: 1.09 to 1.58), age over 80 (OR=1.63, 95% CI: 1.25 to 2.13), impaired balance ability (OR=1.45, 95% CI: 1.20 to 1.75), exercise several times per month (OR=1.69, 95% CI: 1.13 to 2.53), polypharmacy (OR=1.54, 95% CI: 1.19 to 2.00), cognition impairment (OR=1.35, 95% CI: 1.08 to 1.69), mild depression (OR=1.89, 95% CI: 1.47 to 2.45) and moderate depression (OR=3.07, 95% CI: 1.99 to 4.73).ConclusionsThe hazards caused by falls to the elderly in China cannot be ignored. A multidimensional customised fall prevention programme should be considered to reduce the risk of falls among the elderly based on the results above.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China

et al. 2022

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“…In total, 44 participants, aged 50 to 66 years, with a history of AD in their father, mother, or both, and another 44 age-, gender-, and education-matched controls were enrolled from the Natural Population Cohort Study of the West China Hospital at Sichuan University (Peng et al, 2022 ). The control group consisted of individuals whose parents or siblings had not been diagnosed with AD.…”

Section: Methodsmentioning

confidence: 99%

Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease

Peng

Lai

et al. 2023

Front. Hum. Neurosci.

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BackgroundAntisaccade is closely associated with cognitive ability in Alzheimer's disease (AD). However, studies regarding antisaccade in the early stages of AD are scarce. Considering that first-degree family history is a well-established risk factor for AD, we explored the influence of family history on the performance of antisaccade tasks in individuals with normal cognition.MethodsIn total, 44 participants (aged 50–66 years) with a family history of AD (FH+) and 44 age-, gender-, and educational level-matched controls (FH-) were enrolled in our study. After cognitive assessment using the Montreal Cognitive Assessment and Mini-mental State Examination, participants underwent antisaccade trials, and all parameters were recorded using an eye tracker.ResultsWhile the average velocity was relatively lower in FH+ individuals than in FH− individuals (107.9 ± 14.3°/s vs. 132.9 ± 23.7°/s, p < 0.001), FH+ individuals surprisingly showed relatively fewer uninhibited reflexive saccades (44.7 ± 26.0% vs. 56.2 ± 24.7%, p = 0.037) than the control group. They also required a relatively shorter time to detect and correct false saccades (121.6 ± 40.7 ms vs. 143.9 ± 37.0 ms, p = 0.023).ConclusionsThis study showed that family history is associated with alterations in antisaccadic parameters, suggesting that eye tracking can be used to assess oculomotor control and executive function in individuals at risk of developing dementia.

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“…Early life experience has been proven to contribute to the development of depression [ 12 , 13 ]. Many studies in humans have indicated that exposure to separation, mistreatment and loss in early life increases the risk of psychiatric disorders such as depression, anxiety and drug abuse later in life [ 14 , 15 , 16 ]. Maternal separation (MS) is widely used in rodent animals to study the behavior changes and underlying neurobiological mechanisms in emotional disorders.…”

Section: Introductionmentioning

confidence: 99%

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

Zhou

et al. 2022

Brain Sciences

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Background: Psoriasis is a common chronic inflammatory skin disease that often causes depression. Early life experience affects brain development and relates to depression. Whether the effect of different MS protocols in early life on anxiety-like and depressive-like behaviors in female offspring with imiquimod (IMQ)-induced psoriasis is unknown. Methods: C57BL/6J mice were subjected to no separation (NMS), brief MS (15 min/day, MS15) or long MS (180 min/day, MS180) from postpartum days (PPD) 1 to PPD21. Then, 5% imiquimod cream was applied for 8 days in adults. Behavioral tests, skin lesions and hippocampal protein expression were also assessed. Results: We found significant psoriasis-like skin lesions in female mice following IMQ application, and mice showed anxiety-like and depressive-like behaviors. Further, increased microglial activation and decreased expression of neuroplasticity were detected in mice following IMQ application. However, after MS15 in early life, mice showed decreased anxiety-like and depressive-like behaviors, indicating resilience. Further, inhibited hippocampal neuroinflammation and increased neuroplasticity were detected. Conclusions: Collectively, this study confirms that brief MS confers resilience to the behavior deficits in female offspring with IMQ-induced psoriasis and reverses the activation of neuroinflammation and the damage of neuroplasticity injury.

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The impact of childhood parental loss on risk for depression and anxiety in adulthood: A community-based study in Southwest China

Cited by 9 publications

References 25 publications

Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China

Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China

Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

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