The impact of chronic alcohol overuse on heart function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis

Hamala, Piotr; Kasprzak, Jarosław D.; Bińkowska, Anna; Zawitkowska-Witczak, Kamilla; Broncel, Marlena; Piekarska, Anna; Wierzbowska−Drabik, Karina

doi:10.33963/kp.15986

Cited by 3 publications

(6 citation statements)

References 21 publications

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“…Moreover, after 6 months of follow-up, a reduction in E/e' ratio was observed in the abstainers as compared to the control group (P = 0.041) [20]. Thus, the authors postulate E/e' ratio as a predictor of a very early stage of alcohol-related heart dysfunction, and this observation was confirmed in a similar study performed by Rosa G. et al [21].…”

Section: Cardiomyopathysupporting

confidence: 59%

Alcohol—dose question and the weakest link in a chemical interplay

Hamala,

Wierzbowska-Drabik

2023

Explor Cardiol

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The deleterious consequences of alcohol consumption are extensively documented across various dimensions of human health, encompassing somatic disorders such as nervous system impairments, digestive system abnormalities, and circulatory dysfunctions, in addition to socio-psychological aspects. Within the domain of cardiology, a substantial portion of the ongoing scientific discourse centers on elucidating the toxic dose of alcohol. Presented herewith are the findings from a comprehensive review of the latest publications pertinent to this crucial issue.

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Section: Cardiomyopathysupporting

confidence: 59%

Alcohol—dose question and the weakest link in a chemical interplay

Hamala,

Wierzbowska-Drabik

2023

Explor Cardiol

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“…The best absolute cut-off values for outcome prediction were: GLS <18%, layer endocardial strain <19%, and layer epicardial strain <15%. (53) Alcohol related arrhythmias Atrial fibrillation (AF) is the most common arrhythmia observed among alcohol abusers. Larsson and al. proved that during chronic alcohol exposure, an increase in consumption of one AU per day increases the risk of AF by 8%.…”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

Alcohol Impact on the Heart and Cardiovascular System - Hypertrophy, Remodeling and Strain Impairment - Contemporary State-of-the-Art

Hamala,

Wierzbowska-Dravik

2023

Rev Argent Cardiol

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The recent data show that chronic overuse of alcohol may lead to cardiovascular dysfunction, starting from traditionally judged as low ethanol doses, since the burden of arrhythmias, including atrial fibrillation, increases even in moderate alcohol consumers. The other common mechanisms of the disadvantageous impact of ethanol are related to the development of hypertension and its direct aftermath, hypertrophy, fibrosis, and diastolic dysfunction. Since the chance of the reversibility of cardiac remodeling depends on the early diagnosis of cardiac dysfunction, the wider application of novel and sensitive methods of myocardial function assessment, including longitudinal strain of the left and right ventricles, as well as the adapted protocols for stress echocardiography, should be recommended.

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“…So, if alcohol can decrease cardiovascular mortality and the occurrence of diabetes, which non-cardiovascular mortality does it increase then? The risk of mortality is caused by malignant diseases, especially oropharyngeal, laryngeal, liver, colorectal, breast malignancy [16,17], liver cirrhosis, epilepsy, not to mention death by violence, traffic accidents, etc. The proportion of drinkers worldwide has remained the same since 1990; due to population growth, absolute numbers increased from 983 million to 1.34 billion in 2020.…”

Section: Evidence-based Medicinementioning

confidence: 99%

“…In Figure 1, possible harms and benefits are presented. The argument that a decrease of DM2 will decrease its related diseases has not been proven by any study [17]. [2,3,8,12,16,17,21,22].…”

Section: Evidence-based Medicinementioning

confidence: 99%

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Alcohol zero: the end, the beginning of the end, or just the end of the beginning?

Ostojic,

Djajic,

Kovacevic-Preradovic

et al. 2023

Explor Cardiol

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Alcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommended by nutrition committees. Some regional guidelines still recommend one to two standard drinks per day. By the very recent (January 2023), World Health Organization and Canadian Guidance on alcohol emphasize that any alcoholic drink is hazardous to the health and the safe amount is zero. The risk starts with every single drop. It was also nicely summarized in the manuscript “Alcohol-dose question and the weakest link in a chemical interplay” (Explor Cardiol. 2023;1:15–25. doi: 10.37349/ec.2023.00003) especially from the standpoint of a researcher in the cardiovascular arena. The newest recommendations are based on observational studies and their meta-analysis, therefore establishing associations, pointing out that alcohol may somewhat prevent cardiovascular diseases and diabetes type 2, but with a significant increase in non-cardiovascular morbidity and mortality, especially cancers. Previous recommendations, therefore, may be obsolete as they were based on studies where abstainers from alcoholic beverages had inherent higher risks. The current controversy with conflicting guidelines for alcoholic beverage consumption in the era of precision medicine may stimulate more fundamental investigations up to genetic ones and find the cause-effect relations. In the era of precision medicine, it may come closer to discovering the causes of cancers and many other diseases, enabling predictions of reactions to alcoholic beverages by each person, not just in the population.

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The impact of chronic alcohol overuse on heart function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis

Cited by 3 publications

References 21 publications

Alcohol—dose question and the weakest link in a chemical interplay

Alcohol—dose question and the weakest link in a chemical interplay

Alcohol Impact on the Heart and Cardiovascular System - Hypertrophy, Remodeling and Strain Impairment - Contemporary State-of-the-Art

Alcohol zero: the end, the beginning of the end, or just the end of the beginning?

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