The Impact of Chronic Hepatitis B on Quality of Life: A Multinational Study of Utilities from Infected and Uninfected Persons

Abstract

Health states related to CHB infection have substantial reductions in HRQOL and the utilities reported in this study provide valuable information for comparing new treatment options. The observed intercountry differences suggest that economic evaluations may benefit from country-specific utility estimates. The extent that systematic intercountry differences in utilities hold true for other infectious and chronic diseases remains an open question and has considerable implications for the proper conduct and interpretation of economic evaluations.

Economic Evaluation and Budget Impact Analysis of the Surveillance Program for Hepatocellular Carcinoma in Thai Chronic Hepatitis B Patients

“…Direct medical costs consisted of the costs associated with diagnostic tests and treatments used in the screening and enhanced follow-up of the surveillance. Diagnostic test costs were derived from 2009 standard cost list for Health (Levy, et al, 2008) *see detail in method; **adjusted by customer price index (CPI); ***MOPH = Ministry of Public Health; ****cost to charge ratio (1.63) adjusted Technology Assessment of Thailand (Riewpaiboon, 2009) and valued according to the type and the number of tests used in each alternative strategy as presented in the decision tree model. Treatment costs of liver transplantation, resection, RFA, and TACE costs were obtained from the reimbursement claims data of the diagnosis-related groups (DRGs) of C22.0 or HCC for National Health Security Office (NHSO) at the Chulabhorn hospital.…”

“…Health utilities were retrieved from international published studies due to the lack of data in Thailand. The utility weight of CHB patients progressing to the liver health status were reviewed and obtained from one study (Levy et al, 2008). The results were presented as the incremental cost-effectiveness ratio (ICER) in Thai THB per LY or QALY gained which calculated by the incremental costs divided by the incremental effectiveness.…”

Evaluation of the Cost-Effectiveness of Entecavir Versus Lamivudine in Hepatitis BeAg-Positive Chronic Hepatitis B Patients

“…We used the ratings of HBV-associated health states elicited from a representative sample of 100 uninfected individuals in the United States using a visual analogue scale and weighted using the standard gamble method. 34 In this study, probability wheels with 2-color pie charts for the relative probabilities of perfect health and death were used as props for the standard gamble, and a feeling thermometer was used for the visual analogue scale. As a result, we assigned an estimated utility weight of 0.82 for compensated cirrhosis, 0.36 for decompensated cirrhosis, and 0.41 for HCC (Table 1).…”

“…34 To adjust for the health-related quality of life associated with different health states, the relative value, or utility, of each health state was rated compared with a year in perfect health. We used the ratings of HBV-associated health states elicited from a representative sample of 100 uninfected individuals in the United States using a visual analogue scale and weighted using the standard gamble method.…”

Reviews on the Epidemiology, Quality of Life, and Management of Chronic Hepatitis B (CHB)

“…The expansion from traditional clinical outcomes to include HRQOL outcomes will enable us to measure modern health care more sensitively . HRQOL is more sensitive in capturing the effect of illness and interventions for those with uncomplicated disease Levy et al, 2008;Nokhodian, Ataei, Kassaian, Adibi, & Farajzadegan, 2009;S C Ong et al, 2008;Tan, Cheah, Teo, & Yang, 2008;Yi, 2006). Furthermore, HRQOL provides additional information for the prioritization of needs among patients with similar clinical severity defined by traditional clinical outcomes.…”