The impact of chronic suppurative otitis media on children's and teenagers’ hearing

Netto, Luciana Fick Silveira; Costa, Sady Selaimen da; Sleifer, Pricila; Braga, Maria Elisa Luce

doi:10.1016/j.ijporl.2009.09.033

Cited by 26 publications

(16 citation statements)

References 16 publications

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“…It is difficult to perform bone-conduction ABR in the mice because the mouse head is so small. In human patients with active otitis media, lower frequencies are more compromised than higher ones [42]. The mutant mice showed increased mRNA and protein levels of TNF-α and TLR2, which are consistent with the activation of inflammation pathways shared with other OM in mice and humans [29], [37], [43].…”

Section: Discussionsupporting

confidence: 72%

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

et al. 2011

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Craniofacial defects that occur through gene mutation during development increase vulnerability to eustachian tube dysfunction. These defects can lead to an increased incidence of otitis media. We examined the effects of a mutation in the Sh3pxd2b gene (Sh3pxd2bnee) on the progression of otitis media and hearing impairment at various developmental stages. We found that all mice that had the Sh3pxd2bnee mutation went on to develop craniofacial dysmorphologies and subsequently otitis media, by as early as 11 days of age. We found noteworthy changes in cilia and goblet cells of the middle ear mucosa in Sh3pxd2bnee mutant mice using scanning electronic microscopy. By measuring craniofacial dimensions, we determined for the first time in an animal model that this mouse has altered eustachian tube morphology consistent with a more horizontal position of the eustachian tube. All mutants were found to have hearing impairment. Expression of TNF-α and TLR2, which correlates with inflammation in otitis media, was up-regulated in the ears of mutant mice when examined by immunohistochemistry and semi-quantitative RT-PCR. The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2bnee) mirrors craniofacial dysmorphology and otitis media in humans.

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Section: Discussionsupporting

confidence: 72%

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

et al. 2011

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“…concluded that 20 dB or less ABG at 500 Hz and 20–30 dB or less ABG at 1 kHz predict the absence of OC discontinuity, whereas 30 dB or greater ABG at 2 kHz and greater than 40 dB ABG at 4 kHz predict the presence of OC discontinuity in CSOM without cholesteatoma. Silveira Netto et al . found that the ABGs were significantly greater for all frequencies in the cholesteatoma group than in CSOM.…”

Section: Discussionmentioning

confidence: 94%

“…Recent studies showed that the sound pressure difference across the TM serves as a key component of the tympano‐ossicular system for sound transmission . The larger the size of a TM perforation is, the greater the reduction will be in this sound pressure difference resulting in greater losses . TM perforation can be clinically estimated quite precisely as a percentage of the TM area .…”

Section: Discussionmentioning

confidence: 99%

Audiometric correlations with pathologies of ossicular chain in 159 ears with chronic otitis media

Dinç

Damar

Erdem

et al. 2016

Clinical Otolaryngology

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Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle-ear cleft and mastoid mucosa, in which the tympanic membrane (TM) is not intact and recurrent ear discharge or otorrhea is present. 1 Condition of ossicles in ears with CSOM is generally a question preoperatively and it is clear only during an operation. Reliable presurgical diagnosis of interruption or immobility in ossicular chain (OC) would permit a better preoperative counselling and better surgical planning.In this study, we compared the preoperative audiometric measures with the intra-operative findings in the ears with CSOM to identify value of preoperative audiometric evaluation in predicting the presence or absence of an OC pathology. Methods Ethical considerationThis study was reviewed and approved by the institutional review board B€ ulent Ecevit University. ParticipantsThis retrospective study was conducted on 159 ears with CSOM who underwent surgery between December 2012 and January 2015. Both of the ears were evaluated in 12 patients. Diagnoses were rendered according to history of the patients, otomicroscopy, multislice computed tomography (CT) images and audiometry. Exclusion criteria were as follows: (i) ears with cholesteatoma, (ii) tympanic membrane retraction pocket (TMRP), (iii) revision cases, (iv) operations in which the middle ear was not explored, (v) ears with both OC discontinuity and immobility and (vi) craniofacial abnormalities.

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“…Since 2008, we have been studying the pathogenesis of chronic otitis media (COM) by examining the CLE [ 6 ]. Our observations have systematically shown a high prevalence of alterations in the CLE in clinical [ 6 ], histopathological [ 7 ], functional [ 8 ], and radiological [ 9 ] studies. Moreover, the frequency of alterations in the CLE was even higher in patients with cholesteatoma [ 6 , 10 ].…”

Section: Discussionmentioning

confidence: 97%

The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis

Rosito

Sperling

Teixeira

et al. 2018

BioMed Research International

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Objective To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE. Methods Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction. Results TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%; p < 0.0001). Conclusion Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma pathogenesis.

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The impact of chronic suppurative otitis media on children's and teenagers’ hearing

Cited by 26 publications

References 16 publications

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

Audiometric correlations with pathologies of ossicular chain in 159 ears with chronic otitis media

The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis

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