The impact of chronic untreated hyperglycaemia on the long-term stability of paraoxonase 1 (PON1) and antioxidant status in human sera

Macharia, Muiruri; Kengne, André Pascal; Blackhurst, Dee; Erasmus, Rajiv T; Matsha, Tandi E.

doi:10.1136/jclinpath-2013-201646

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…There was also absent the FR of the PEMs of these mice. According to the literature data, chronic hyperglycemia can trigger lipid peroxidation, decrease the stability of the antioxidant system, and damage the vascular endothelium [32,33], resulting in increased levels of proinflammatory cytokine, like TNF-α and other markers of systemic inflammation in the blood, as well as the functional activity of macrophages [34][35][36][37][38]. Since the level of TNF-α excretion is characterized by a clear positive correlation with the degree of obesity and insulin resistance, the correction of products of this proinflammatory cytokine is considered by many researchers as a promising therapeutic approach to the treatment of obesity and insulin resistance [34].…”

Section: Term Of Observation Daysmentioning

confidence: 99%

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Лазаренко¹,

Mel'nikova²,

Бабенко³

et al. 2018

Preprint

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Introduction. The use of probiotics demonstrate efficacy against obesity and metabolic syndrome (MetS). Detection effective probiotic strains for hyperglycemia and immunity associated with is important task. The aim of the study was to evaluate an influence of Lactobacillus casei IMV B-7280 separately and composition L. casei IMV B-7280 / Bifidobacterium animalis VKB / B. animalis VKL on the levels of blood glucose and immunity in obese mice. Meterials and methods. Obesity was induced by fat-enriched diet (FED) in male BALB/c mice. Obese mice were transferred to standard diet and received per os probiotic strains daily during 10 days. We measured tumor necrosis factor-a (TNF-a) in blood serum using enzyme-linked immunosorbent assay and functional activity of peritoneal exudate macrophages (PEMs). Glucose levels in blood was defined with glucometer. Results. We ascertained that all probiotic strains induced reducing mice weight and visceral fat, normalization of TNF-a production and functional activity of PEMs. Treatment with L. casei IMV B-7280 was associated with decreasing blood glucose levels. No normalization of glucose and TNF-a levels in obese mice, transferred to standard diet without probiotic treatment, although we revealed decreasing their weight and visceral fat and partial recover of functional activity of PEMs. Conclusions. Probiotic strain L. casei IMV B-7280 (separately) and composition L. casei IMV B-7280 / B. animalis VKB / B. animalis VKL can re-equilibrate metabolic and inflammation indices in mouse obesity model. L. casei IMV B-7280 alone was more efficient in decreasing glucose levels than composition of strains.

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Section: Term Of Observation Daysmentioning

confidence: 99%

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Лазаренко¹,

Mel'nikova²,

Бабенко³

et al. 2018

Preprint

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Probiotic Concepts of Predictive, Preventive, and Personalized Medical Approach for Obesity: Lactic Acid Bacteria and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles

Лазаренко

Melnykova

Бабенко

et al. 2023

Advances in Predictive, Preventive and Personalised Medicine

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A review of epidemiologic studies of low-level exposures to organophosphorus insecticides in non-occupational populations

Reiss

Chang

Richardson

et al. 2015

Critical Reviews in Toxicology

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This paper systematically reviews epidemiologic studies related to low-level non-occupational exposures to organophosphorus (OP) insecticides. Many of the studies evaluate levels of maternal OP metabolites and subsequent health outcomes in offspring. The studies focused primarily on birth outcomes (e.g., infant body weight or head circumference) and neurodevelopmental (e.g., mental and psychomotor) testing results. The evidence from these studies was reviewed under the Bradford Hill guidelines. Most of the studies assessing exposure based on urinary levels of OP insecticide metabolites used only one or two measurements during pregnancy. The potential for exposure misclassification with this method is largely due to (1) preformed metabolites that are ingested with food, (2) the short elimination half-life of OP insecticides, and (3) lack of specificity to particular OP insecticides for many of the metabolites. For birth outcomes, the majority of reported results are not statistically significant, and the associations are inconsistent within and across studies. There is more within-study consistency for some of the neurodevelopmental testing results, although few associations were examined across several studies. These associations are generally weak, have been replicated only to a limited extent, and require further confirmation before they can be considered established. The OP insecticide levels measured in the epidemiologic studies are too low to cause biologically meaningful acetylcholinesterase inhibition, the most widely used metric for OP insecticide toxicity. Overall, the available evidence does not establish that low-level exposures to OP insecticides cause adverse birth outcomes or neurodevelopmental problems in humans.

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The impact of chronic untreated hyperglycaemia on the long-term stability of paraoxonase 1 (PON1) and antioxidant status in human sera

Abstract: The results indicate that baseline glycaemic status may contribute to a decline in the stability of antioxidant activity and extent of lipid peroxidation but not PON activity.

Cited by 3 publications

References 23 publications

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Probiotic Concepts of Predictive, Preventive, and Personalized Medical Approach for Obesity: Lactic Acid Bacteria and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles

A review of epidemiologic studies of low-level exposures to organophosphorus insecticides in non-occupational populations

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