The impact of cigarette smoking on human semen parameters and hormones

Abstract

Smoking does not affect conventional semen parameters, but significantly increases round cells and leukocytes. Only a few idiopathic infertile smokers were able to quit smoking.

The Effect of Environmental Tobacco Smoke on the Testicular Functions of 7-10 Years Old Children

“…In literature, there are several cross-sectional studies about the effects of active or passive smoking on semen quality or testicular hormone levels, but most of which have included adolescent or adult patients or have been done in rats. 12,14,17,18 Some studies have shown a negative effect of smoking on semen quality in terms of the conventional semen characteristics whereas others could not demonstrate such an effect. 12,17 Furthermore, it has not been clarified whether smoking has an impact on levels of male reproductive hormones.…”

“…12,14,17,18 Some studies have shown a negative effect of smoking on semen quality in terms of the conventional semen characteristics whereas others could not demonstrate such an effect. 12,17 Furthermore, it has not been clarified whether smoking has an impact on levels of male reproductive hormones. Significantly increased, 12 decreased and unchanged levels of total testosterone in male smokers have been reported in various studies.…”

“…12,17 Furthermore, it has not been clarified whether smoking has an impact on levels of male reproductive hormones. Significantly increased, 12 decreased and unchanged levels of total testosterone in male smokers have been reported in various studies. 12,13,17 In a study semen parameters and hormone concentrations of infertile smokers had been compared with infertile non-and ex-smokers.…”

“…However, a majority of investigations about the relationship between male reproductive system and tobacco smoke are about the effect of active smoking in adults or ETS exposure in rats. [11][12][13][14] The main objective of the current study was to evaluate the effects of ETS exposure on testicular function in children.To our knowledge, it is the first study conducted in the literature. For assessing ETS exposure in children a parent-completed questionnaire and the measurement of serum cotinine level were used.…”

Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients

“…A receptor for androgens has been reported to occur in NSCLCs (Beattie et al, 1985;Kaiser et al, 1996) and there may be cooperative interaction between the hormones and active mutations of EGFR during the development of lung cancer. Previous reports have suggested that smoking increases the levels of androgens in men and women (Law et al, 1997;Trummer et al, 2002) and carcinogens from cigarette smoke may disrupt androgen function by reducing androgen receptor (AR) levels in androgenresponsive organs (Lin et al, 2004).…”