The impact of climate change on atopic dermatitis and mental health comorbidities: a review of the literature and examination of intersectionality

Abstract

Climate change, fueled by increasing concentrations of greenhouse gases, is associated with rising temperatures, extreme weather events, increased aeroallergen production, and air pollution. Our understanding that many inflammatory cutaneous diseases carry important mental health comorbidities is expanding. Simultaneously, the detrimental impacts of climate change on human health are now widely recognized as a global public health crisis. Importantly, these climate‐associated phenomena exacerbate the environmental triggers of atopic dermatitis (AD) and are also associated with amplification of comorbid mental health conditions in AD including depression, anxiety, trauma‐related disorders, and psychotic spectrum disorders. This review is the first to examine the nexus of climate change, atopic dermatitis, and mental health comorbidities and emphasizes the disproportionate impacts of climate change in vulnerable and marginalized populations.

Burden of atopic dermatitis in Europe: A population‐centred approach leveraging web search data in 21 European countries

“…1,6,7 Consequently, climate change poses an enormous challenge for AD management. 4,35,36 Evolving climate conditions, changing allergen distribution, elevated air pollution and increased individual stress levels may exacerbate both the skin disease and its comorbidities. 4,6,35,36 As AD-related Internet searches strongly T A B L E 2 Spearman's correlations between available monthly weather parameters (mean precipitation amount (mm), global radiation (W/m 2 ), mean sunshine duration (h), mean wind speed (m/s), mean temperature (°C) and mean relative humidity (%)) and the combined web search volume per 100,000 inhabitants for the search terms "atopic dermatitis", "atopic eczema" and their lay terms for each European country studied between February 2019 and January 2023. correlated with AD prevalence and also reflected the seasonality of AD flares, monitoring web searches and combining them with environmental data could be a cost-effective approach to gain further insights into the impact of climate change on AD.…”

“…1 Due to its pruritic, eczematous, relapsing nature and association with several comorbidities, including food allergy, asthma and allergic rhinitis, the patients' quality of life, happiness and mental health are also affected. [1][2][3][4] Considering these aspects, AD was ranked as the skin disease with the highest disease burden in terms of disabilityadjusted life-years (DALYs) in 2017. 5 The aetiology of AD is multifactorial, ranging from genetic to socioeconomic and environmental factors.…”

“…Atopic dermatitis (AD), also known as atopic eczema (AE), is the most common chronic inflammatory skin disease worldwide 1 . Due to its pruritic, eczematous, relapsing nature and association with several comorbidities, including food allergy, asthma and allergic rhinitis, the patients' quality of life, happiness and mental health are also affected 1‐4 . Considering these aspects, AD was ranked as the skin disease with the highest disease burden in terms of disability‐adjusted life‐years (DALYs) in 2017 5 …”

Architecture as Urban Catalyst: Infographic Design Guideline on Kuala Lumpur Riverfront Revitalisation

“…These efforts align with the United Nations Sustainable Development Goals (SDGs), emphasizing 'Good Health and Well-Being' and 'Clean Water and Sanitation' for global development (Bozdağ, 2022;Lederman & Anders Whitney, 2022). Given the current global health challenges such as rising poverty, crime rates, mental health issues, and overloaded healthcare systems due to non-communicable diseases (Kam et al, 2023;Ramos et al, 2023;, the need to focus on improving access to spaces fostering community activities and wellbeing is paramount (Bozdağ, 2022;Lederman & Anders Whitney, 2022). In this context, the sustainable and effective design of the riverfront along the Klang River presents a significant opportunity to create activity spaces that bring joy to the community while also aligning with the UN SDGs' objectives in safeguarding Kuala Lumpur's urban community (Connolly, 2020).…”

Anti-amyloid Monoclonal Antibodies in Alzheimer’s Disease: A New Hope

“…3 The disease has a considerable influence on the economy as a global public health crisis. 2,4 The main primary hallmarks of the disease are neurofibrillary tangles and amyloid plaques caused by intracellular tau protein hyperphosphorylation. 5 The amyloidogenic cascade and its peptide byproducts play a significant role in the start of AD.…”