The impact of clonal hematopoiesis on outcomes in patients with aplastic anemia

Brzeźniakiewicz‐Janus, Katarzyna; Rupa‐Matysek, Joanna; Hoppe, Anna; Gil, Lidia

doi:10.5603/ahp.a2021.0026

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The Benign Clone1

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2023

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“…Since the 'genetic revolution' there has been a race to find a genetic abnormality which is specific to the diagnosis of acquired SAA. Unfortunately, although several cytogenetic and molecular abnormalities have been discovered, we still do not have diagnostic tests [1]. Nevertheless, these progresses in genetic have allowed to discriminate between different types of conditions that may overlap with aplastic anaemia picture, such as myelodisplastic syndrome (MDS) and hypoplastic MDS (hMDS).…”

Section: The Benign Clonementioning

confidence: 99%

The Benign Clone Causing Aplastic Anaemia

McCann

Piccin

2023

Thalassemia Reports

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Severe Aplastic Anaemia (SAA) is a rare benign disease but carries a high-mortality rate unless treated in a specialised centre. Overwhelming laboratory and clinical evidence points to an autoimmune pathogenesis; although, the aetiology remains obscure in the majority of cases. The differential diagnosis in older patients is problematical and a diagnosis of hypoplastic myelodysplasia remains difficult. This review points out the difficulty in diagnosis without a specific test. Future research needs to define a specific diagnostic test and refine therapeutic interventions.

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Section: The Benign Clonementioning

confidence: 99%