The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis

Tarrants, M.; Oleen-Burkey, MerriKay; Castelli-Haley, Jane; Lage, Maureen J.

doi:10.1155/2011/271321

Cited by 61 publications

(60 citation statements)

References 38 publications

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“…The unpredictable progression of MS may contribute to a higher level of depression among patients with a child due to uncertainty about the future. There is strong evidence in the literature regarding the relationship between higher number of symptoms and higher level of disability, and depression (10,20,31,(37)(38)(39). By restricting patients' daily activities and leading to social isolation, symptoms such as incontinence may be overwhelmingly conducive to depressive symptoms in chronic diseases (40).…”

Section: Discussionmentioning

confidence: 99%

Multipl Skleroz Hastalarinda Umutsuzluk, Depresyon Ve Yaşam Doyumu

Aşiret¹,

Özdemir²,

Maraşlıoğlu³

2014

tnd

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Objective: This study was carried out to determine the level of hopelessness, depression, and life satisfaction among patients with multiple sclerosis. Ma te ri al and Met hod:Sixty-five patients with multiple sclerosis, treated at the neurology clinic of a university hospital, were included in this study. In this descriptive study, a data collection form developed by the researchers, the Beck Depression Scale, and the Beck Hopelessness and Life Satisfaction Scale were used.Re sults: Almost half (43.1%) of the patients exhibited severe depressive symptoms. Patients' hopelessness and life satisfaction levels were moderate. The scores on depression and life satisfaction scales were correlated negatively. While patients' traits including female gender, low economic level, difficulties in walking, and fatigue were associated with reduced life satisfaction; variables such as having a child, low economic and education levels, experiencing incontinence, and fatigue were related to a higher level of depressive symptoms. Conclusion:The majority of patients were depressed; life satisfaction and hopelessness levels were moderate. Linear regression analysis revealed that education and emotional problems determined 42% of the depression score; and economic level and emotional problems identified 32% of the life satisfaction score. ÖzetAmaç: Bu çalışma multipl skleroz (MS) hastalarının umutsuzluk, depresyon ve yaşam doyumu düzeyini belirlemek amacıyla yapılmıştır.Ge reç ve Yön tem: Çalışmaya, bir üniversite hastanesinin nöroloji kliniğinde tedavi gören 65 MS hastası alınmıştır. Bu tanımlayıcı çalışmada, araştırmacılar tarafından geliştirilen veri toplama formu, Beck Depresyon ve Beck Umutsuzluk ve Yaşam Doyumu Ölçekleri kullanılmıştır. Bulgular:Hastaların yarıya yakını (%43,1) ciddi depresif semptomlar göstermektedir. Hastaların umutsuzluk ve yaşam doyumu düzeyleri ortadır. Depresyon ve yaşam doyumu ölçek skorları ters ilişkilidir. Kadın cinsiyet, düşük ekonomik düzey, yürümede zorluk ve yorgunluk gibi hasta özellikleri bozulmuş yaşam doyumuna eşlik ederken çocuk sahibi olma, düşük ekonomik ve eğitim düzeyi, inkontinans ve yorgunluk deneyimleme gibi değişkenler yüksek düzeyde depresif semptomlarla ilişkilidir.Sonuç: Hastaların çoğunluğu depresyondadır; yaşam doyumu ve umutsuzluk düzeyleri ortadır. Linear regresyon analizi, eğitim ve duygusal problemin depresyon ölçeği skorunu %42 oranında, ekonomik düzey ve duygusal problemin ise yaşam doyumunu %32 oranında belirlediğini göstermiştir. (Türk Nöroloji Dergisi 2014; 20:1-6) Anah tar Ke li me ler: Multipl Skleroz, depresyon, yaşam doyumu, hemşirelik

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Section: Discussionmentioning

confidence: 99%

Multipl Skleroz Hastalarinda Umutsuzluk, Depresyon Ve Yaşam Doyumu

Aşiret¹,

Özdemir²,

Maraşlıoğlu³

2014

tnd

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“…4,5 Depression is also associated with lower immunotherapy adherence rates and might thus have direct consequences for overall health outcome. 6 Moreover, depression is one of the main predict-ors for suicidal ideation and suicide risk in patients with muliple sclerosis. 7 If left untreated, depressive symptoms in multiple sclerosis rarely remit spontaneously, often become chronic, 8 and can worsen over time, particularly in patients with scores indicative of clinical depression at the study baseline.…”

mentioning

confidence: 99%

An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial

Fischer

Schröder

Vettorazzi

et al. 2015

The Lancet Psychiatry

123

131

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“…17 It is also associated with a higher rate of hospitalizations 18 and lower adherence to disease modifying therapy (DMT). 19 Depression seems to be more common early in the disease course 20 and is associated with relapses. 21 In secondary progressive MS patients, feelings of hopelessness become more common.…”

mentioning

confidence: 99%

Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions

Brenner

Piehl

2016

Acta Neurol Scand

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Multiple sclerosis (MS) is a neuroinflammatory condition with a prominent progressive neurodegenerative facet that typically affects young-or middle-aged adults. Although physical disabilities have been in the foreground by being easier to assess, there is an increasing interest in mental disabilities and psychiatric co-morbidities, which have a disproportionally high impact on important outcome measures such as quality of life and occupational disability. In particular, cognitive impairment, depression and mental fatigue, which mutually interact with each other, seem to be of importance in this context. In recent decades, major efforts have been invested in developing more effective disease modulatory treatments. This has resulted in novel therapeutic options and awareness of the importance of early intervention. In comparison, good quality and adequately powered studies on symptomatic treatments of fatigue and psychiatric co-morbidities in MS are rare, and awareness of treatment options is much lower. We here review the existing evidence base for symptomatic treatment of fatigue and depression in MS patients. With regard to fatigue, off-label prescription of alertness improving drugs is common, in spite of all but absent evidence of efficacy. In contrast, a number of smaller studies suggest that physical exercise and fatigue management courses may have some clinical benefit. Very few studies have addressed the efficacy of antidepressants and non-pharmaceutical interventions specifically in MS patients. Therefore, treatment guidelines largely rely on data from non-MS populations. In the future, there is a strong motive to direct additional resources to the study of these important aspects of MS. K E Y W O R D Scognitive symptoms, depression, fatigue, multiple sclerosis, treatment

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The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis

Cited by 61 publications

References 38 publications

Multipl Skleroz Hastalarinda Umutsuzluk, Depresyon Ve Yaşam Doyumu

Multipl Skleroz Hastalarinda Umutsuzluk, Depresyon Ve Yaşam Doyumu

An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial

Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions

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