The Impact of Compaction Force on Graft Consolidation in a Guided Bone Regeneration Model

Viteri-Agustín, Iratxe; Brizuela-Velasco, Aritza; Lou-Bonafonte, José Manuel; Jiménez-Garrudo, Antonio; Chávarri-Prado, David; Pérez-Pevida, Esteban; Benito-Garzón, Lorena; Gruber, Reinhard

doi:10.11607/jomi.8082

Cited by 1 publication

(3 citation statements)

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“…These results are in line with those obtained previously by Viteri-Agustín et al [3], who studied the effect on bone regeneration in the vertical direction by applying different biomaterial compression forces in a model of a critical defect in a rabbit calvaria. Despite not observing statistically significant differences between the different compression forces, they did obtain significantly higher percentages of bone neoformation in the regions closest to the calvaria in both groups, albeit with lower values (29.0 ± 8.8% in the cases of lower compression forces and 27.6 ± 8.2% in the cases of higher compression forces) than the cases in our study.…”

Section: Discussionsupporting

confidence: 92%

“…The external cortex of the working area was removed with a tungsten carbide round handpiece bur (HM141F 031, Meisinger, Neuss, Germany), resulting in two defects of 8 mm diameter and 0.5 mm depth with a medullary bone base. Using two pins (Bone Management Master-Pin-Control ® , Meisinger, Neuss, Germany), titanium cylinders (Soadco S.L., Escaldes-Engordany, Andorra) designed specifically for this methodology and referenced in previous studies [3] were fixed. This process is shown in Figure 1.…”

Section: Anesthesia and Surgical Protocolmentioning

confidence: 99%

“…However, advances in biomaterials and clinical techniques have led to the incorporation of guided bone regeneration (GBR) as a potential alternative in challenging cases [2]. GBR is based on the principle of cell exclusion, where the use of membranes serves as a barrier to prevent epithelial and connective 2 of 12 tissue from colonizing the space to be regenerated, which is usually filled with particulate grafts [3].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

Montalbán-Vadillo,

Pérez-Pevida,

Viteri-Agustín

et al. 2024

JCM

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Background: Although xenografts have shown successful results in GBR procedures due to their osteoconductive properties, many authors have opted to add co-adjuvant drugs to favor osteogenesis and differentiate cells into an osteoblastic lineage. Metformin has been shown to have bone-protective properties, regulating osteoclast differentiation, as well as the ability to promote osteoblast mineralization and differentiation. The present study aimed to evaluate the effect of the local application of a 1% metformin solution on bone neoformation in the treatment of an experimental bone defect in a guided bone regeneration animal model with a particulated bovine hydroxyapatite xenograft with hyaluronate. Methods: With this purpose in mind, two critical defects with 8 mm diameter and 0.5 mm depth were created in eight male New Zealand rabbit calvarias. Titanium cylinders were fixed in each defect and filled with particulate hydroxyapatite of bovine origin and sodium hyaluronate, with sterile injectable saline added to the control group and sterile 1% metformin solution added to the test group. At 6 weeks, the animals were euthanized, and samples were obtained and prepared for histomorphometric analysis. Results: A higher percentage of new bone formation was observed in the metformin samples than in the control samples, both in the region closest to the animal’s calvaria and in the most distal region analyzed. A higher average bone–biomaterial contact percentage was observed in the samples, with metformin in both the proximal and distal regions. There was no statistically significant difference in the mean value in either region in both parameters. Conclusion: The local application of a 1% metformin solution in an animal model of guided bone regeneration with particulate bovine hydroxyapatite and hyaluronate resulted in greater bone neoformation and xenograft osseointegration than in the control group.

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Section: Discussionsupporting

confidence: 92%

Section: Anesthesia and Surgical Protocolmentioning

confidence: 99%