The impact of concomitant administration of vanadium and insulin on endothelial dysfunction markers (PAI-1 and ET-1) in type 1 diabetic rats

Morsy, Mohamed D; Bin-Jaliah, Ismaeel; Bashir, Salah O; Shatoor, Abdullah S.; Haidara, Mohamed A

doi:10.1080/13813455.2019.1573840

Cited by 2 publications

(6 citation statements)

References 32 publications

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“…Sample size was from 20 57 to 90 2 animals. Streptozotocin 2 , 12 - 14 , 16 - 21 , 37 - 42 , 44 , 45 , 48 - 61 or alloxan monohydrate 6 , 8 , 11 , 22 , 24 , 46 , 47 , 62 , 63 wereused for inducing diabetes, except for one study 43 that used high-fat low-sucrose diet for inducing insulin resistance. All of the studies were accomplished on rodents.…”

Section: Resultsmentioning

confidence: 99%

“…All of the studies were accomplished on rodents. In 8 studies, 38 , 40 , 41 , 44 , 58 , 61 Sprague-Dawley rats were used, while in the rest, Swiss Albino of Wistar strain rats were investigated. Additionally, 3 studies 2 , 16 , 43 were on mice species.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, 3 studies 2 , 16 , 43 were on mice species. Rat’s mean weight was 175 g and mice’s mean weight was 26.5 g. Sources of vanadium consumed for administration were vanadyl sulfate (20 studies), 2 , 12 , 17 , 18 , 21 , 39 - 42 , 44 , 48 - 51 , 53 , 54 , 57 , 58 , 60 sodium orthovanadate (10 studies), 6 , 8 , 11 , 19 , 22 , 37 , 46 , 62 - 64 oxovanadium (IV) complex (1 study), 2 vanadium pentoxide (2 studies), 20 Na[(O2)2(2,2’-bpy)] • 8 H2O vanadium complexes (1 study), 13 vanadyl(IV)-ascorbate (VOAsc) complex (1 study), 43 dioxidovanadium cis-[VO2(obz)py]) complex (1 study), 38 NaVO3 (3 studies), 21 , 47 vanadium-3-hydroxy flavone complex (1 study), 59 macrocyclic binuclear oxovanadium (IV) complex (MBOV) (1 study), 14 bis(maltolato)oxovanadium (IV) (2 studies), 16 , 45 dioxidovanadium (1 study), 61 vanadium citrate (1 study), 24 V3dipic-Cl 21 and oxovanadium(IV) chelate [VOL] (1 study). 51 Method of administration was either by dissolving into drinking water, 6 , 8 , 11 , 16 , 17 , 19 , 21 , 22 , 24 , 37 , 40 , 41 , 44 - 47 , 57 - …”

Section: Resultsmentioning

confidence: 99%

“… 16 , 42 , 47 , 53 , 54 Vanadyl sulfate supplementation could also significantly augment SOD level. 2 , 21 , 41 , 42 , 44 , 48 , 50 , 53 , 54 , 60 Other compounds such as oxovanadium (IV) complex, sodium orthovanadate, [VO(SO4)(1,10’-phen)] • 2 H2O, [VO(SO4)(2,2’-bpy)] • H2O, vanadyl(IV)-ascorbate, Dioxidovanadium (V) complex, vanadium-3-hydroxy flavone complex, macrocyclic binuclear oxovanadium (IV) complex, bis(maltolato)oxovanadium IV (BMOV), vanadium citrate, vanadium pentoxide also enhanced SOD level in different tissues of animals. 2 , 6 , 8 , 13 , 14 , 16 , 19 , 20 , 22 , 24 , 37 , 38 , 43 , 46 , 51 , 59 , 63 …”

Section: Resultsmentioning

confidence: 99%

“…Vanadyl sulfate supplementation significantly reduced TNF-α, IL-6, and hs-CRP. 40 , 41 , 44 , 58 , 63 Vanadyl (IV)-ascorbate (VOAsc) complex and dioxidovanadium also reduced these inflammatory biomarkers. 43 , 61 Caspase 3 level significantly decreased after oxovanadium (IV) complex and VOSO4 treatment.…”

Section: Resultsmentioning

confidence: 99%

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Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Ghalichi

Ostadrahimi

Saghafi-Asl

2022

Health Promot Perspect

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Background: Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. Methods: A systematic search was conducted using the PubMed, Scopus, and web of science databases from 1990 to 2021, according to the inclusion and exclusion criteria. The search strategy was based on the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA). Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. Results: In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. A minor risk of bias was reported, based on the SYRCLE’s tool. Conclusion: According to the findings, well-designed clinical trials are warranted to assess the long-lasting effects of various vanadium compounds on inflammatory and oxidative stress biomarkers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Ghalichi

Ostadrahimi

Saghafi-Asl

2022

Health Promot Perspect

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Can atypical response in endothelial dysfunction-related genes and microRNAs arise from low hydrogen peroxide exposure?

URHAN-KUCUK,

TERZI

2024

BLL

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OBJECTIVE: Vascular endothelium is a tissue in which several vasoactive substances are produced and secreted. Reactive oxygen species can cause endothelial dysfunction (ED). miRNAs can be implicated in the oxidative stress-related ED during vascular disease pathogeneses. Our aim is to investigate effect of H 2 O 2induced oxidative stress on expression levels of genes and miRNAs that are key players in ED. METHODS: H 2 O 2 effect on cell viability of human umbilical-vein endothelial cells (HUVEC) at 24-hour was measured with MTT. Low sub-cytotoxic H 2 O 2 concentrations (25, 50 μM) were selected to analyze their oxidative stress-inducing capacities with MDA assay and their effects on EDN1, NOS3, VCAM1, SERPINE1, miR21, miR22, miR126, and miR146a levels with RT-qPCR. RESULTS: Each tested H 2 O 2 concentration reduced HUVEC cell viability. Fifty μM H 2 O 2 augmented cellular MDA levels. Intriguingly, EDN1, VCAM1, and SERPINE1 and all analyzed miRNAs' levels attenuated upon H 2 O 2 treatment whereas there was no change in NOS3 levels compared to control. There was a positive correlation between miR-21 and VCAM1. CONCLUSION: Rat her than individual alterations in analyzed parameters, consistent changes in our fi ndings i.e., parallel decreases in EDN1, VCAM1, SERPINE1 mRNA levels as well as miRNAs, suggests that H 2 O 2 concentration-dependent modulation of expression patterns can bring about various impacts on ED (Tab. 1, Fig. 5, Ref. 63). Tex t in PDF www.elis.sk KEY WORDS: oxidative stress, endothelial dysfunction, hydrogen peroxide (H 2 O 2 ), microRNA, gene expression.

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The impact of concomitant administration of vanadium and insulin on endothelial dysfunction markers (PAI-1 and ET-1) in type 1 diabetic rats

Cited by 2 publications

References 32 publications

Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies

Can atypical response in endothelial dysfunction-related genes and microRNAs arise from low hydrogen peroxide exposure?

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